AssociationofNucleophosminNegativelyRegulatesCXCR4-MediatedGProteinActivationandChemotaxis
...eotidesthatencodethecorrespondingaminoacidresidues.SegmentsencodingtheCL-2(Asp133-K154)andCXCR4C-ter(Ala303-Ser352)wereachievedfrompcDNA3-Myc-CXCR4-WTusingpolymerasechainreaction.SegmentswereclonedintopGEX-4T2(GEHealthcare,ChalfontSt.Giles,Buckinghamshire,UK)atBamHI/XhoIsitestomakeGSTfusionproteinco...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期AnnexinA2heterotetramer:roleintightjunctionassembly
...middot;HCl,pH7.0.2-DSDS-PolyacrylamideGelElectrophoresis2-DelectrophoresiswasperformedaccordingtothemethodofO‘Farrell(64)byKendrickLaboratories.Isoelectricfocusingwascarriedoutinglasstubesof2.0-mminnerdiameter,using2.0%Resolytes,pH4-8ampholines(BDHfromHoeferScientificInstruments,SanFrancisco,CA)fo...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第9期StaphylococcusaureusPanton-ValentineleukocidindirectlytargetsmitochondriaandinducesBax-independentapoptosisofhumanneutrophils
...wasassociatedwitharapiddisruptionofmitochondrialhomeostasisandactivationofcaspase-9andcaspase-3,suggestingthatPVL-inducedapoptosisispreferentiallymediatedbythemitochondrialpathway.PolymorphonuclearcellexposuretoPVLleadstomitochondriallocalizationofthetoxin,whereasBax,1ofthe2essentialproapoptoticmemb...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期EstrogensandInsulin-LikeGrowthFactorModulateNeoplasticCellGrowthinHumanCholangiocarcinoma
...stsinablindmanner.ER-andER-ßimmunohistochemicalexpressionwasevaluatedaspreviouslydescribed.11-13Briefly,sixslideswereanalyzedpereachspecimenofnormalliverorcholangiocarcinoma.Neoplasticornormalcholangiocyteswerecountedinarandom,blindedmannerinsixnonoverlappingfields(magnificationx20)ofeachslide...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第9期TheThree-SubstitutedIndolinoneCyclin-DependentKinase2Inhibitor3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one(SU9516)Kill
...2003),andthereforeitrepresentsaprototypeofsuchagents.ItisapproximatelytwiceaspotentaninhibitorofCDK2comparedwithCDK1,andmorethan20-foldmorepotentagainstCDK2thanCDK4(Laneetal.,2001).InRKO,SW480,andothercoloncarcinomacelllines,SU9516selectivelyinhibitedCDK2activityandpotentlyinducedapoptosisinassociat...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期StructuralFeaturesoftheGlutamateBindingSiteinRecombinantNR1/NR2AN-Methyl-D-aspartateReceptorsDeterminedbySite-DirectedMutagenesisandMolecular
...ofaminoacidslocatedwithintheS1andS2ligandbindingdomainsoftheNR2AN-methyl-D-aspartate(NMDA)receptorsubunittoexplorethenatureofligandbinding.Wild-typeormutatedNR1/NR2ANMDAreceptorswereexpressedinXenopuslaevisoocytesandstudiedusingtwoelectrodevoltageclamp.WeinvestigatedtheeffectsofmutationsintheS1andS2...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期Lightchaineditinggeneratespolyreactiveantibodiesinchronicgraft-versus-hostreaction
...dies(auto-Abs).Wefoundanti-DNAAbsthatreactedtoseveraldifferentantigens,suchasphosphatidylserine,myelinbasicprotein,thyroglobulin,histone,insulin,cytochromeC,and-galactosidase.ThispolyreactivitywasfoundforAbsfromBcellsthatexpressedthe56RHchaintransgenewith“editor“Lchainsthatdidnotcompletelyvetoau...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期Eotaxin-3andauniquelyconservedgene-expressionprofileineosinophilicesophagitis
...ationofanEEtranscriptsignatureprovidedavaluableopportunitytouncovercriticalaspectsofdiseasepathogenesis.First,wewereinterestedindeterminingwhethertheallergicandnonallergicvariantsofEEhaddifferenttranscriptprofiles.WhenwecomparedthefullEEtranscriptprofilebetweenallergen-sensitizedandnon–allergen-se...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期BlockofC/EBPfunctionbyphosphorylationinacutemyeloidleukemiawithFLT3activatingmutations
...S21A)wasstablyexpressed.Incontrast,therewasnoeffectwhenserine21wasmutatedtoaspartate(S21D),whichmimicsphosphorylationofC/EBP.Thus,ourresultssuggestthattherapiestargetingtheMEK/ERKcascadeordevelopmentofproteintherapiesbasedontransductionofconstitutivelyactiveC/EBPmayproveeffectiveintreatmentofFLT3mut...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期Inhibitionofthec-JunN-TerminalKinase-MediatedMitochondrialCellDeathPathwayRestoresAuditoryFunctioninSound-ExposedAnimals
...celldeathpathway(i.e.,activationofBax,releaseofcytochromec,activationofprocaspases,andcleavageoffodrin).Fluoresceinisothiocyanate(FITC)-conjugatedD-JNKI-1peptideappliedontoanintactcochlearRWMdiffusesthroughthismembraneandpenetratescochleartissueswiththeexceptionofthestriavascularis.Atimesequenceoffl...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期