“Y染色體中特異性甲基化位點作爲癌症診斷標誌物的應用”專利成果轉讓
前列腺癌在男性腫瘤中發病率佔第一位,死亡率佔第二位,而隨着人口的老齡化,我國前列腺癌病人幾年內將高達幾百萬人,因此對前列腺癌的診斷具有非常強大的臨牀和產業發展需求。當前因無特異性很高的前列腺癌早期診斷...
醫藥經濟;生物技術;技術要聞ComparingGenomesofHelicobacterpyloriStrainsfromtheHigh-AltitudeDesertofLadakh,India
...so,H.pylorifromIndiahasbeenresistanttocommonlyprescribeddrugs,likemetronidazole(19).Duetoanextremelyhighrateofcolonization,theincidenceofgastroduodenaldiseaseslinkedtoH.pylori,suchasgastric-duodenalulcersandstomachcancer,isthoughttobeveryhigh,buttheseincidencerateshavebeengrosslyunderestimatedaslowt...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期Dualfortificationofsaltwithiodineandmicronizedferricpyrophosphate:arandomized,double-blind,controlledtrial
MichaelBZimmermann,RitaWegmueller,ChristopheZeder,NourredineChaouki,FabianRohner,MohammedSaïssi,ToniTorresaniandRichardFHurrell1FromtheHumanNutritionLaboratory,SwissFederalInstituteofTechnology,Zürich,Switzerland(MBZ,RW,CZ,FR,andRFH);theMinistryofHealth,Rabat,Morocco(NC);theMinistryofHealt...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第4期Irondeficiencyduetoconsumptionofahabitualdietlowinbioavailableiron:alongitudinalcohortstudyinMoroccanchildren
MichaelBZimmermann,NourredineChaoukiandRichardFHurrell1FromtheHumanNutritionLaboratory,SwissFederalInstituteofTechnology,Zürich,Switzerland(MBZandRFH),andtheMinistryofHealth,Rabat,Morocco(NC).2SupportedbytheThrasherResearchFund(SaltLakeCity,UT),theNestléFoundation(Lausanne,Switzerland),t...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第1期GlucosylceramidesynthaseisanessentialregulatorofpathogenicityofCryptococcusneoformans
...arenvironments,suchasinalveolarspacesandinthebloodstream,whicharecharacterizedbyaneutral/alkalinepH,butnotinthehostintracellularenvironment,suchasinthephagolysosomeofmacrophages,whichischaracteristicallyacidic.Indeed,aC.neoformansmutantstrainlackingGlcCerdidnotgrowinvitroataneutral/alkalinepH,yetith...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期InvivoanalysisoftheroleofaberranthistonedeacetylaserecruitmentandRARblockadeinthepathogenesisofacutepromyelocyticleukemia
...roteinofacutepromyelocyticleukemia(APL)isoncogenicinvivo.IthasbeenhypothesizedthattheabilityofPML-RARtoinhibitRARfunctionthroughPML-dependentaberrantrecruitmentofhistonedeacetylases(HDACs)andchromatinremodelingisthekeyinitiatingeventforleukemogenesis.ToelucidatetheroleofHDACinthisprocess,wehavegener...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期4-Hydroxy-2-nonenalAdductionofExtracellularSignal-RegulatedKinase(Erk)andtheInhibitionofHepatocyteErk-Est-LikeProtein-1-ActivatingProtein-1Sign
...dependentlossofconstitutiveErk-1/2phosphorylation,activity,andnuclearlocalization.Thesefindingswereconsistentwithiron-inducedintracellularLPO,whichalsoresultedinaconcentration-dependentdecreaseinhepatocyteErk-1/2phosphorylationandactivity.4-HNEandiron-inducedinhibitionofErk-1/2wasinverselycorrelated...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期ContributionofDNApolymerasetoimmunoglobulingenehypermutationinthemouse
...partofthemutagenesisatA/Tpositions.TranslesionalDNApolymerasesarespecificenzymes,recruitedatreplicationforksstalledinfrontofnoninstructionalDNAlesions,andabletobypassthemwithvariousspecificitiesandefficiencies(forreviewseereference14).Moreover,basedoninvitroassays,manyofthemareinherentlyerrorpronewh...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期UseofPCRTargetingofInternalTranscribedSpacerRegionsandSingle-StrandedConformationPolymorphismAnalysisofSequenceVariationinDifferentRegions
...1,ITS2,ITS3,ITS4,invSR1R,andLR12R)wereused,andtheamplifiedproductswereanalyzedbysingle-strandedconformationpolymorphism(SSCP)analysis.DendrogramsoftheseSSCPpatterns,preparedonthebasisofJaccard‘scoefficient,indicatedthatthePCRproductsobtainedwithprimerpairITS1andITS2werethebestfortheidentificationo...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第2期VaccinationpreservesCD4memoryTcellsduringacutesimianimmunodeficiencyviruschallenge
...lresponsesinalltissuesexaminedand,importantly,inducedantibodiesthatneutralizedtheprimaryisolateofSIVusedforchallenge.Finally,wedemonstratethattheextentofpreservationoftheCD4memorycompartmentduringtheacutephaseprovidesastrongpredictorforsubsequentprogressiontodeath.Ourdataprovideamechanismtoexplaincl...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期