HIV-1ProteaseandReverse-TranscriptaseMutations:CorrelationswithAntiretroviralTherapyinSubtypeBIsolatesandImplicationsforDrug-ResistanceSurvei
...mparedtheprevalenceofproteaseandreverse-transcriptase(RT)mutationsinHIV-1sequencesfrompersonswithandwithoutprevioustreatmentwithproteaseinhibitors(PIs),nucleosideRTinhibitors(NRTIs),andnonnucleosideRTinhibitors(NNRTIs).Treatment-associatedmutationsinproteaseisolatesfrom5867personsandRTisolatesfrom62...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第15期ThePimkinasescontrolrapamycin-resistantTcellsurvivalandactivation
...seofPim-1–/–Pim-2–/–cells.Thus,endogenouslevelsofthePimkinasesarerequiredforTcellstomountanimmuneresponseinthepresenceofrapamycin.Theexistenceofarapamycin-insensitivepathwaythatregulatesTcellgrowthandsurvivalhasimportantimplicationsforunderstandinghowrapamycinfunctionsasanimmunomodulatorydru...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第2期SubtypeHypertensionandRiskofStrokeinMiddle-AgedandOlderChinese
...cHealth,PrinceofWalesHospitalShatin,NT,HongKong,ChinaDepartmentofNeurology(Q.-D.Y.),InstituteofNeurology,TheXiangyaHospital,CentralSouthUniversity,Changsha,P.R.ChinaInstituteofNeurology(F.-Z.S.),MedicalCollege,UniversityofHenan,Zhengzhou,P.R.ChinaDepartmentofNeurology(M.-L.R.),MedicalCollege,Univers...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第1期TcelllineagechoiceanddifferentiationintheabsenceoftheRNaseIIIenzymeDicer
...of-expressingthymocyteswerenotaffected.Indevelopingthymocytes,Dicerwasnotrequiredforthemaintenanceoftranscriptionalsilencingatpericentromericsatellitesequences(constitutiveheterochromatin),themaintenanceofDNAmethylationandXchromosomeinactivationinfemalecells(facultativeheterochromatin),andthestables...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期Modelofalbuminreabsorptionintheproximaltubule
【摘要】Normally,thesmallamountofalbuminwhichpassesthroughtheglomerularcapillarywallisalmostcompletelyreabsorbedintheproximaltubule,viaanendocyticmechanism,butthereabsorptiveprocesscanbeoverwhelmedifthefilteredloadofalbuministoolarge.Toexaminethefactorsthatcontrolthefractionalreabsorptionofalbum...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第1期超高效液相色譜—質譜法快速分析番茄及其製品中矮壯素和縮節胺殘留量
...取,但對定性離子的選擇未作詳細描述。色譜柱中使用小顆粒填料,極大地提高了高效液相色譜的分離能力和靈敏度。應用超高效液相色譜串聯質譜(UPLC/MSMS)檢測的方法未見報道。 本實驗應用Waters公司的針對強極性...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Inflammation-inducedlymphangiogenesisinthecorneaarisesfromCD11b-positivemacrophages
...lymphaticvessels(Figure1C)appearedtocoalescewithlymphaticvessels,raisingthequestionastohowthelymphaticvesselsareformed.Someofthelymphaticvesselsdidnothaveconnectionswithlimballymphaticvessels(Figure1,DandE).Sevendaysaftercornealtransplantation,weobservedtheselymphaticvesselsinthecentralareaofthecorn...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期RecruitmentofFoxp3+TregulatorycellsmediatingallografttolerancedependsontheCCR4chemokinereceptor
...,Foxp3,agenethatencodesaforkhead/wingedhelixtranscriptionfactorScurfin,isrequiredforTregcelldevelopmentandstudiessupportitsutilityasamarkerofTregcells(10,11).Ofthemultipleformsofcostimulationblockadethatcanpromotelong-termengraftmentinrodentmodels,onlytargetingofCD40–CD154interactions,typicallyinc...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期頭孢曲松鈉對菌血症小鼠腸道膜菌羣的影響
...明小鼠126只,體質量18~25g,飼養在普通級動物設施內,顆粒飼料用微波爐加熱消毒處理,飲水經高壓滅菌處理,均自由攝取。實驗動物和顆粒飼料均購於青島市實驗動物與動物實驗中心。小鼠購後統一餵養顆粒飼料1周,以使腸...
醫源資料庫;在線期刊;齊魯醫學雜誌;2007年第22卷第4期Caspasesandcalpainareindependentmediatorsofcisplatin-inducedendothelialcellnecrosis
...ainingwith50µMcisplatinat24hwasreducedbyeitherthepancaspaseinhibitor,Q-VD-OPH,orthecalpaininhibitor,PD-150606.Calpaininhibitorhadnoeffectoncaspase-3-likeactivity.Inconclusion,incisplatin-treatedendothelialcells,caspases,themajormediatorsofapoptosis,canalsocausenecrosis.Acalpaininhibitorprotect...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期