Effectsofcalcium,dairyproduct,andvitaminDsupplementationonbonemassaccrualandbodycompositionin10-12-y-oldgirls:a2-yrandomizedtrial
...ysupplementationinnormalgrowingchildren.ACKNOWLEDGMENTSWethankErkkiHelkala,Pia-LeenaSalo,MiiaKemikangas,LeilaVilkki,andShumeiChengfortheirvaluableworkandtechnicalassistanceonthisproject.SCwasresponsibleforandinvolvedintheconception,management,design,andfundingofthestudy,aswellassubjectrecruitment,da...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第5期ShouldProgestinsBeBlamedfortheFailureofHormoneReplacementTherapytoReduceCardiovascularEventsinRandomizedControlledTrials?
...morelikelyinpatientswithcertainheritableconditions,suchasplateletantigen-2(PIA-2)polymorphisms.102Further,factorVLeidenmutationincreasestheriskofprimaryandrecurrentvenousthromboemboliceventsby3-to6-fold103andtheriskofmyocardialinfarction.104Indeed,ERTandHRTmaydecreaseorincreaseatherothrombosisriskde...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第7期IdentificationofSmall-MoleculeInhibitorsofRGS4UsingaHigh-ThroughputFlowCytometryProteinInteractionAssay
...ormationinducedbyGDPandAlF-4.Weusedaflowcytometryproteininteractionassay(FCPIA)approachbasedonpreviousstudiesmeasuringGandsubunitsinteractions(Sarvazyanetal.,1998)andligand-receptor-G-proteininteractions(Sklaretal.,2002;Simonsetal.,2003).UsingFCPIA,wescreeneda3028-compoundlibraryfromtheChembridgescr...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期第四章 血型與輸血--第一節 血型
...原命名國際命名系統抗原舊名稱系統抗原HPA-1HPA-1aHPA-1bZW,PIAZWa,PIA1ZWb,PIA2HPA-2HPA-2aHPA-2bKO,SIBKOBKOA,SIBHPA-3HPA-3aHPA-3bBAKBAKA,LEKABAKBHAP-4HAP-4aHPA-4bPEN,YUKPENA,YUKBPENB,YUKAHAP-5HPA-5aHPA-5bBR,HC,ZAVBRBZAVBBRA,HCA,ZAVA 注:ICSH:國際血液學...
醫源資料庫;醫源圖書館;教材類;臨牀基礎檢驗學DistinctiveroleofStat3andErk-1/2activationinmediatinginterferon-inhibitionofTGF-1action
...ns-activationofmanyTGF-targetgenes.IthasbeenreportedthatinhibitionofStat3byPIAS3,amemberoftheproteininhibitorofactivatedStat(PIAS)family,activatesSmadtranscriptionalresponses(16).PIAS3canformaternarycomplexwithSmad3andgeneraltranscriptionalcoactivatorp300/CBPandactivateSmadtranscriptionalactivity.Co...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第5期淋病
...克隆抗體對淋球菌進行血清學分型。它以兩種形式表達即PIA和PIB。它可在細胞膜上形成孔道。使水溶性物質、其他對細菌代謝有重要作用的物質及某些抗生素可通過細胞膜進入細胞內。蛋白Ⅱ與淋球菌同人類上皮細胞、白細胞的...
求醫問藥;疾病手冊;皮膚性病科TheThree-SubstitutedIndolinoneCyclin-DependentKinase2Inhibitor3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one(SU9516)Kill
...miodide(PI)assays,cellswerestainedwithAnnexinV-fluoresceinisothiocyanateandPIandevaluatedforapoptosisbyflowcytometryaccordingtothemanufacturer‘sprotocol(BDBiosciencesPharMingen).Inbrief,1x106cellswerewashedtwicewithice-coldPBSandstainedwith5µlofAnnexinV-fluoresceinisothiocyanateand10µl...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期AssessmentofHemostaticRiskFactorsinPredictingArterialThromboticEvents
...y1studyshowingariskbetweenLAandischemicstroke.Ithasalsobeenproposedthat?2-GPIantibodiesaretheprimaryLAsubtypeassociatedwiththromboticoutcomes,butthedataareinconclusive.InarecentstudybyVeresetal,42theauthorsreportthatthefrequencyandtitersofanti–?2-GPIantibodiesweresignificantlyhigherinpatientswitha...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第10期GeneticDeterminantsofArterialThrombosis
...abletotheinteractionbetweenthese2riskfactors.GlycoproteinsIa/IIaandIb/IX/VGPIa/IIa(integrin2?1)isthemajorplateletcollagenreceptorandisresponsibleforplateletadhesiontotheexposedvesselwall;theGPIb/IX/VcomplexisthemainreceptorforvWF.InthegeneencodingtheGPIbsubunit,alengthpolymorphismwithavariablenumber...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第2期KnockyourSOCSoff!
...ogy1–containingtyrosinephosphatase(SHP1),proteininhibitorofactivatedSTAT(PIAS),andSOCS(2).Thelatterfamilyiscomprisedofcytokine-inducibleSH2-containingproteinandSOCS1–SOCS7.SOCSsarefurthermoreinducedbycytokinesignalingandthereforeformaclosed-loop,negative-feedbackcontrolmechanism(Figure1).Figure1...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期