ApplicationofaMolecularPanelToDemonstrateEnterotropicVirusSheddingbyHealthyandHumanImmunodeficiencyVirus-InfectedPatients
...mongthemostcommondebilitativeconditionsaffectinghumanimmunodeficiencyvirus(HIV)-infectedpeople,rangingfrom50%toalmost100%ofAIDSreports.Inthisrespect,inthesepatientsemergingviralentericpathogens(i.e.,picobirnaviruses,astroviruses,andcaliciviruses)aremorefrequentlyassociatedwithdiarrheathaneither“cl...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期人類首次完全確定艾滋病毒毒株源頭來自黑猩猩
研究:艾滋病病毒來源於黑猩猩人類首次確定源頭中新網3月4日電據外媒報道,多國科學家研究發現,艾滋病毒已知的4種病株,均來自喀麥隆的黑猩猩及大猩猩,是人類首次完全確定艾滋病毒毒株的所有源頭。目前已知艾滋病毒...
行業資訊;臨牀快報;HIV/AIDS恩曲他濱合成工藝改進
...酶抑制劑。該藥物與其他的抗逆轉錄病毒藥物聯用於成人HIV-1感染的治療。本品口服後被磷酸化爲具有細胞活性的5’-三磷酸鹽,5’-三磷酸鹽通過進入病毒DNA主鏈,與主鏈結合,導致鏈終止,從而抑制HIV-1逆轉錄酶及HBVDNA...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2009年第9卷第2期干擾素在治療愛滋病相關綜合徵中的應用
...研究表明:干擾素可用來治療慢性乙型肝炎和丙型肝炎,HIV陽性患者,與AIDS有關的卡波濟氏肉瘤(KS)和慢性疲勞綜合徵(CFS)。 AIDS即獲得性免疫缺陷綜合徵,臨牀主要表現爲:發熱、體重減輕、食慾不振,其併發症主要有卡氏...
合作平臺;醫學論文;臨牀醫學與專科論文;藥學OligonucleotideLigationAssayforDetectionofMutationsAssociatedwithReverseTranscriptaseandProteaseInhibitorResistanceinNon-BSubtypesandRecomb
...XTMethodstoidentifyresistancemutationsinthehumanimmunodeficiencyvirustype1(HIV-1)polgeneareneededsincetheuseofprotease(PR)and/orreversetranscriptase(RT)inhibitorsmayincreasetheprevalenceofresistancemutations(9,11).DNAsequencingisthemostcommonlyusedmethodtoevaluatethepresenceofdrugresistancemutations...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期AlcoholAbuseEnhancesNeuroinflammationandImpairsImmuneResponsesinanAnimalModelofHumanImmunodeficiencyVirus-Encephalitis
...uroinflammatorydisorders(includinghumanimmunodeficiencyvirus-1encephalitis,HIVE)areassociatedwithoxidativestressandinflammatorybraininjury,andexcessivealcoholusecanexacerbatetissuedamage.UsingamurinemodelofHIVE,weinvestigatedtheeffectsofalcoholabuseontheclearanceofvirus-infectedmacrophagesandneuroin...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第4期envGeneTypingofHumanImmunodeficiencyVirusType1StrainsonElectronicMicroarrays
...BSTRACTTheNanoChipsystemwasusedforsubtypinghumanimmunodeficiencyvirustype1(HIV-1)strainsusingprobescomplementarytotheV1regionoftheenvgene.Probesforsixsubtypes(AtoD,F,andG)andtwocirculatingrecombinantforms(AGandAE)ofHIV-1groupMwereincluded.Thespecificityoftheseoligonucleotideshadbeenevaluatedprevious...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期LessonsfromFailurePreparingforFutureHIV-1VaccineEfficacyTrials
...nfectiousDiseasesreporttheanalysisofthefirstphase3efficacytrialofacandidateHIV-1vaccine.ThetrialwassuccessfullyconductedandshowedthatthevaccinedidnotpreventHIV-1infection.Thisvaccine,whichwascomposedofrecombinantgp120(rgp120)inalum,wastheculminationoftesting1dozenmonomericenvelopeglycoproteinsubunit...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第5期DiminishedReplicativeFitnessofPrimaryHumanImmunodeficiencyVirusType1IsolatesHarboringtheK65RMutation
...ences,Inc.,FosterCity,CaliforniaABSTRACTThehumanimmunodeficiencyvirustype1(HIV-1)reversetranscriptase(RT)resistancemutationK65RconfersintermediatelevelsofresistancetoseveralRTinhibitors,includingathree-tofourfoldreductionoftenofovirsusceptibility.Here,wehaveusedforthefirsttimeprimaryHIV-1isolatesfro...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期BreastCancerResistanceProtein(BCRP/ABCG2)InducesCellularResistancetoHIV-1NucleosideReverseTranscriptaseInhibitors
...ninCD4+Tcellsconferredcellularresistancetohumanimmunodeficiencyvirustype-1(HIV-1)nucleosidereversetranscriptaseinhibitors.ThecelllineMT-4/DOX500wasestablishedthroughthelong-termcultureofMT-4cellsinthepresenceofdoxorubicin(DOX)andhadreducedsensitivitytonotonlyDOXbutalsozidovudine(AZT).MT-4/DOX500cell...
醫源資料庫;在線期刊;分子藥理學雜誌;2003年第63卷第1期