Rapamycinatsubimmunosuppressivelevelsinhibitsmesangialcellproliferationandextracellularmatrixproduction
...dneycollagenTHEGROWTHANDDIFFERENTIATIONofmammaliancellsinresponsetonutrientsareregulatedbythemammaliantargetofrapamycin(mTOR)kinases.DownstreamtargetsofmTORkinaseactivityincludeseveralfactorsthatregulatetranslation,suchastheeukaryotictranslationinitiationfactors4G1and4B(eIF4G1andeIF4B)andthetranslat...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第1期腎臟纖維化的發生機制與高血壓相互關係
...,這一舒張作用是通過小動脈的內膜來調節的。以此推測SAR小動脈內膜的異常,原發性高血壓時,腎小動脈血管阻力增加,血流量減少也可能與小動脈乙酰膽鹼的血管舒張作用減弱有關係[17]。2.2腎臟纖維化引起高血壓的機...
醫源資料庫;在線期刊;中華中西醫雜誌;2007年第8卷第15期NicotineEnhancesAngiotensinII-InducedMitogenicResponseinVascularSmoothMuscleCellsandFibroblasts
...andadventitialfibroblast.Thenicotine-inducedDNAsynthesiswasnotaffectedbyvalsartan,anAT1receptor-specificblocker,orPD123319,anAngIItype2(AT2)receptor-specificantagonist.NicotineorAngIIstimulationrapidlyincreasedextracellularsignal-regulatedkinase(ERK)activation,tyrosine-andserine-phosphorylationofsig...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第1期RoleofADPRibosylationFactor1intheAssemblyandSecretionofApoB-100–ContainingLipoproteins
...hodsPleaseseetheonlineMethods,availableathttp://atvb.ahajournals.org.ResultsARF1T31NInterferesWiththeSecondStepofVLDLAssemblySucrosegradientultracentrifugation12(forMethodsseehttp://atvb.ahajournals.org)demonstratedheterogeneityoftheapoB-100–containinglipoproteinssecretedfromMcA-RH7777cells(Figure...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第3期CerebrovascularNitrosativeStressMediatesNeurovascularandEndothelialDysfunctionInducedbyAngiotensinII
...sthetizedwithisoflurane(maintenance2%),intubated,andartificiallyventilated(SAR-830;CWEInc).8,9Thefemoralvesselswerecannulatedforrecordingorarterialpressure,bloodsamplecollection,andAngIIadministration.Rectaltemperaturewasmaintainedat37°C.Aftersurgery,anesthesiawasmaintainedwithurethane(750mg/kg;...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第2期InternallyControlledReal-TimePCRMonitoringofAdenovirusDNALoadinSerumorPlasmaofTransplantRecipients
...minatedinfectionshavebeenfoundtoincreaseoverthelastfewyears.SevereinfectionsarepredominantlybutnotexclusivelycausedbysubgroupCadenoviruses.Amultiplexreal-timePCRassayusingmolecularbeaconsasprobeswasdevelopedtoenablemonitoringofadenovirusDNAinthosepatientswithsimultaneousidentificationofsubgroups.Ani...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期InteractionsofTGF-dependentandmyogenicoscillationsintubularpressure
...mediatedoscillationwhenambienttubularflowwasinterrupted.Twowell-definedpeaksarepresentinthemeanpowerspectrumofstop-flowpressure(SFP)centeringat25and100mHz(n=13),inadditiontoasmallpeakat125130mHz.Bispectralanalysisindicatesthattwooftheseoscillations(30and100mHz)interactnonlinearlytoproducethethirdosc...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第2期RoleofBloodCell-AssociatedAT1ReceptorsintheMicrovascularResponsestoHypercholesterolemia
...dbyactivationandadhesionofbloodcells.TheangiotensinIIreceptor-1antagonistLosartanpreventstheinductionoftheseresponses.Theobjectiveofthisstudywastodeterminetherelativecontributionsofbloodcell-associatedversusendothelium-associatedAT1a-Rtothesehypercholesterolemia-inducedmicrovascularalterations.Metho...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第2期InSilicoPredictionofPregnaneXReceptorActivatorsbyMachineLearningApproache
...tingPXRactivators.BecauseofthestructuraldiversityofPXRactivators,moreeffortsareneededforexploringmethodsapplicabletoabroaderspectrumofcompounds.Weexploredthreemachinelearningmethods(MLMs)forpredictingPXRactivators,whichweretrainedandtestedbyusingsignificantlyhighernumberofcompounds,128PXRactivators(...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期APregnaneXReceptorAgonistwithUniqueSpecies-DependentStereoselectivityandItsImplicationsinDrugDevelopment
...mayalsohavetherapeuticpotentialbyremovingendogenousandexogenoustoxins.Inthisarticle,wereportthesynthesisandidentificationofnovelPXRagonistsfromalibraryofpeptideisosteres.CompoundS20,aC-cyclopropylalkylamide,wasfoundtobeaPXRagonistwithbothenantiomer-andspecies-specificselectivity.S20hasthreechiralcar...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期