NAD(P)HOxidaseeCDependentSelf-PropagationofHydrogenPeroxideandVascularDisease
...ide(NO·),H2O2influencesdifferentaspectsofendothelialcellfunctionviacomplexmechanisms.ThisreviewdiscussesrecentadvancesestablishingacriticalroleofH2O2inthedevelopmentofvasculardisease,inparticular,atherosclerosis,andmechanismswherebyvascularNAD(P)HoxidaseeCderivedH2O2amplifiesitsownproduction.Recent...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期CharacterizationofanNBS1C-TerminalPeptideThatCanInhibitAtaxiaTelangiectasiaMutated(ATM)-MediatedDNADamageResponsesandEnhanceRadiosensitivity
...ylinositol3-kinasefamilyandisactivatedbyIRinanNBS1-dependentmanner.TheextremeCterminusofNBS1containsanevolutionarilyconservedsequencemotifthatiscriticalforbindingtoandactivationofATMafterIR.ATMphosphorylatesaseriesoftargetstoinitiatecellcyclearrestandpromotecellsurvivalinresponsetoDNAdamage.Therefor...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期OsteoprotegerinInactivationAcceleratesAdvancedAtheroscleroticLesionProgressionandCalcificationinOlderApoE-/-Mice
...elopmentsuggestingthatcalcificationofadvancedatheroscleroticlesionsincludesmechanismsthatrecapitulateboneformation.Severaloftheseproteinssuchasosteoprotegerin(OPG),8matrix-glaprotein,9osteopontin,10andpyrophosphatase11havebeenidentifiedasinhibitorsofvascularcalcification.OPGisacriticalmodulatorofbon...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期ParthenolideModulatestheNF-B-MediatedInflammatoryResponsesinExperimentalAtherosclerosis
...ctivityoncancercells,16raisingthepotentialuseasanantitumoragent.However,itsmechanismofactioninatherosclerosishasnotbeeninvestigated.Becauseseverallinesofevidencesupporttheideathatantiinflammatoryinterventionscaninhibitthedevelopmentofatherosclerosisanditsclinicalcomplications,inthisstudy,wereportthe...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期HIF-1expressionfollowsmicrovascularlossinadvancedmurineadriamycinnephrosis
...mercialtargetretrievalbuffer(Dako).AratmonoclonalantibodytomouseCD34(1:400,MEC14.7,CedarlaneLaboratories)wasusedfor1hatroomtemperature.Biotin-conjugatedrabbitanti-ratimmunoglobulin(Dako)wasusedasasecondaryantibody.Sitesofsecondaryantibodybindingweredemonstratedusingastreptavidin-peroxidaseconjugate(...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第1期ComparisonofGeneticBackgroundsofMethicillin-Resistantand-SusceptibleStaphylococcusaureusIsolatesfromPortugueseHospitalsandtheCommunity
...nesidentifiedinPortuguesehospitalshavenotoriginatedfromtheintroductionofSCCmecintodominantMSSAbackgroundspresentinthePortuguesenosocomialorcommunityenvironmentbutwereprobablyimportedfromabroad.Incontrast,theMRSAPediatricclonemighthaveoriginatedinourcountrybytheacquisitionofSCCmectypeIVintoMSSAcloneC...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期FunctionalCharacterizationofBoneMorphogeneticProteinBindingSitesandSmad1/5ActivationinHumanVascularCells
...esshighspecific125I-BMP4binding,whereashumanmicrovascularendothelialcells(HMEC-1)andhumanpulmonaryarteryendothelialcells(HPAECs)exhibitlowbinding.BMP4competesforbothhigh-andlow-affinity125I-BMP4bindingsitesonHPASMCs,yetBMP2competesonlyatthelow-affinitybindingsites.Inaddition,BMP4,butnotBMP2,inducedS...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第2期EndotoxinUp-regulatesInterleukin-18
...ecover,eitherspontaneouslyorwithtreatment,mayhaveimpairedbacterialclearancemechanisms,andthiscouldberelatedtotheabilityoftheseindividualstomountanIL-18response.AlthoughLPSwasalsodetectedinnormalBALfluidthelevelsweresignificantlylowerandderivedfromdifferentbacterialspeciesthantheLPSinthesarcoidsample...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第11期EffectofhypoenergeticfeedingonmuscleoxidativephosphorylationandmitochondrialcomplexIIVactivitiesinrats
...deprivationwhencomparedwithnormallyfedrats.Thesefindingsmaypartlyexplainthemechanismofreducedmuscleenergeticsinenergymalnutrition.KeyWords:MalnutritionenergymetabolismoxidativephosphorylationrespiratorychainhypoenergeticfeedingcomplexactivityratsINTRODUCTIONHypoen...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第5期Lung-marginatedMonocytesModulatePulmonaryMicrovascularInjuryduringEarlyEndotoxemia
...regulatingcelladhesionmolecules(CAMs)vialocal,cell-contact,andTNF-dependentmechanisms.Someoftheresultsofthesestudieshavebeenpreviouslyreportedintheformofabstracts(24–26).METHODSAnimalsAllprotocolswerereviewedandapprovedbytheU.K.HomeOffice,inaccordancewiththeAnimals(ScientificProcedures)Act1986,Uni...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第11期