Commentson“CalpainMediatestheDioxin-InducedActivationandDown-RegulationoftheArylHydrocarbonReceptor“
...fCYP1A1.DavarinosandPollenz(1999)alsoshowedthatthecalpaininhibitorN-acetyl-Leu-Leu-Met-aldehydedidnotblockAHRdegradationinaratcellline.Moreimportantly,MaandBaldwin(2000)aswellasRobertsandWhitelaw(1999)demonstratedthatthespecificproteasomeinhibitorlactacystin(noreportedcross-reactivitywithcalpains)in...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期瘧原蟲抗藥性的遺傳學研究進展
...Ser→Asn或Thr,51位Asn→Ile,59位Cys→Arg,16位Ala→Val,164位Ile→Leu。單一點突變所致DHFR108位Ser變異成Asn即可產生乙胺嘧啶抗性,但對環氯胍的反應性僅稍有降低。對乙胺嘧啶產生高度抗性則需其他位點突變共存,包括51位Asn→Ile和(或...
合作平臺;醫學論文;基礎醫學論文;寄生蟲學EffectofCathepsinKInhibitorBasicityoninVivoOff-TargetActivities
...yl)-N2-{(1S)-2,2,2-trifluoro-1-[4‘-methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide(L-873724),apotentnonbasiccathepsinKinhibitorwithasimilaroff-targetprofile,althoughallthreeinhibitorsprovidedsimilarplasmaexposures.Usinganactivity-basedprobe,125I-BIL-DMK,invivoinhibitionofcathepsinsB,L,andSwasdet...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期第四節 胃腸道粘膜T淋巴細胞
...增殖。抑制B淋巴細胞分化。其表面糖蛋白主要爲CD45RA和leu8(CD8),證明是幼稚T淋巴細胞。它們對抗原刺激的增殖反應低,對刀豆素A等有絲分裂促進劑的增殖反應高,產生IL-2和γ-INF低,輔助作用弱。GALTT淋巴細胞如何調節 B淋巴...
醫源資料庫;醫源圖書館;教材類;實用免疫細胞與核酸CharacterizationofaNovelPKAPhosphorylationSite,Serine-2030,RevealsNoPKAHyperphosphorylationoftheCardiacRyanodineReceptorinCanineHeartFailu
...dusedtoidentifyadditionalPKAphosphorylationsitesinRyR2attheKeckFacilityofYaleUniversity.TheantieCserine-2030phosphorylationsiteantiserumwascustom-generatedbyGlobalPeptideServices.AnexpandedMaterialsandMethodssectioncanbefoundintheonlinedatasupplementavailableathttp://circres.ahajournals.org.ResultsM...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期MutantFibrinogenClearedfromtheEndoplasmicReticulumviaEndoplasmicReticulum-AssociatedProteinDegradationandAutophagy
...r,hsdS20(rBC,mBC),recA13,supE44,ara14,galK2,lacY1,proA2,rpsL20(Smr),xyl5,C,leu,andmtl)waspurchasedfromInvitrogenCorp.(Carlsbad,CA).TheP.pastorisstrainusedinthisstudywasGS115/his4(Invitrogen).TheSaccharomycescerevisiaestrainsusedwerewildtype22:BY4742/MAT,his31,leu20,lys0,andura30;BY4742:pep422/MAT,hi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第4期VasoactiveIntestinalPeptideTransactivatestheAndrogenReceptorthroughaProteinKinaseA-DependentExtracellularSignal-RegulatedKinasePathwayinProst
...beforeVIPorDHTtreatment.Reagents.VIPandVIPreceptorantagonist[D-P-Cl-Phe(6)-Leu(17)]-VIPwerepurchasedfromAmericanPeptide(Sunnyvale,CA).Bicalutamide(Casodex)wasagiftfromAstra-ZenecaPharmaceuticals(Cheshire,UK).ThemouseIgG,mouseanti-ARantibody,mouseanti-VPAC2-R,rabbitanti-PSAantibody,polyclonalanti--ac...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第7期粘附分子基因多態性與冠心病
...8個在外顯子序列上。其中4個多態性(Ser290Asn,Asn562Asp,Leu599Val和Thr715Pro)可以改變P-選擇素的氨基酸序列。5’端區域的基因多態性與心肌梗死無關[5]。 ECTIM研究中發現,與對照組人羣相比,Pro715基因型在心肌梗死病人中...
醫源資料庫;在線期刊;中華醫藥雜誌;2006年第6卷第1期NeutrophilElastaseConvertsHumanImmatureDendriticCellsintoTransformingGrowthFactor-ß-SecretingCellsandReducesAllostimulatoryAbility
【摘要】Duringmicrobialinfection,neutrophils(polymorphonuclearleukocytes;PMNs)activatedendriticcells(DCs).However,earlyreportsillustratedthatneutrophil-derivedmediatorsmaysuppressresponsestomitogens.Inthepresentstudy,weinvestigatedthemechanismusedbyPMNstomodulatetheimmunostimulatoryabilityofDCs....
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期14-3-3蛋白
...e14-3-3proteinsareafamilyofabundant,widelyexpressedacidicpolypeptidesinalleukaryocyticcells,whichactmainlyaseitherhomodimersorheterodimers.The14-3-3proteinsinteractwithtargetingproteinsortwodifferentdomainsinonetargetingproteinbyphosphoserine/phosphothreoninemotifs.Sevendifferent,buthighlycons...
醫源資料庫;在線期刊;中華醫學研究雜誌;2006年第6卷第10期