年齡相關黃斑變性的分子病理學
ProgRetinEyeRes.2008Nov6.[Epubaheadofprint]年齡相關黃斑變性(AMD)是全球不可逆性失明的首要原因。儘管AMD的病因和發病機制尚未完全清楚,但目前普遍認爲其中涉及了遺作者:
行業資訊;臨牀快報;老年醫學Effectofdietaryluteinandzeaxanthinonplasmacarotenoidsandtheirtransportinlipoproteinsinage-relatedmaculardegeneration
...zeaxanthinareassociatedwithanincreasedriskofage-relatedmaculardegeneration(AMD).NostudieshavechallengedAMDpatientswithadiethighinluteinandzeaxanthin.Objective:TheobjectivewastoexaminetheeffectofdietsloworhighinluteinandzeaxanthinonplasmacarotenoidsandtheirtransportinAMDpatients.Design:SevenAMDpatien...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第3期TherelationbetweenCreactiveproteinandagerelatedmaculardegenerationintheCardiovascularHealthStudy
...ACTAim:Totestthehypothesisthatindividualswithagerelatedmaculardegeneration(AMD)haveincreasedCreactiveprotein(CRP)levels.Methods:AcrosssectionalstudydesignusingdatafromtheCardiovascularHealthStudy(CHS),alongitudinalstudythatenrolledolderadultsfromfourcommunitiesintheUnitedStatesfrom1989to1990,wasempl...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第9期加拿大科研人員基於多胺全新抑癌基因網絡
...中,有兩個分別是腺苷脫羧酶(adenosylmethioninedecarboxylase1,AMD1),以及真核生物翻譯啓動因子5A(eIF5A),這兩個因子都與hypusine有關(hypusine是一種獨特的氨基酸,由一種高保守途徑產生的多胺代謝產物)。研究人員進一步通過二...
行業資訊;臨牀快報;腫瘤相關Acasecontrolstudyofagerelatedmaculardegenerationanduseofstatins
...Acceptedforpublication8April2005ABSTRACTAims:Agerelatedmaculardegeneration(AMD)istheleadingcauseofblindnessinindustrialisedcountries.Previousstudieshavesuggestedthatstatinsmayhaveaprotectiveeffectagainstthedisease;however,existingstudieshavehadlimitedpowertoreliablydetectorexcludeaneffectandhaveprod...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第9期世界首次RNAi臨牀試驗初獲成功
...示,導致老年人失明的最常見病因——老年性黃斑變性(AMD),能夠通過一小段遺傳物質來對付。美國費城Acuity製藥公司近日公佈了評估RNA干擾(RNAi)療法對人類患者效果的首次臨牀II期試驗的初步結果。 這項臨牀試驗檢測...
行業資訊;臨牀快報;RNA研究Associationbetweendietaryglycemicindexandage-relatedmaculardegenerationinnondiabeticparticipantsintheAge-RelatedEyeDiseaseStudy
...llen.taylor{at}tufts.edu.ABSTRACTBackground:Age-relatedmaculardegeneration(AMD)isthemajorcauseofirreversibleblindness.AMDappearstoshareseveralcarbohydrate-relatedmechanismsandriskfactorswithdiabetes-relateddiseases,includingretinopathyandcardiovasculardisease(CVD);however,todate,onlyonesmallstudyhas...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第1期Correlationofopticalcoherencetomography,withorwithoutadditionalcolourfundusphotography,withstereofundusfluoresceinangiographyindiagnosingch
...ethodmayhavearoleasascreeningtooltohelpprioritiseFFArequests.Abbreviations:AMD,agerelatedmaculardegeneration;CNV,choroidalneovascularmembrane;FFA,fundusfluoresceinangiography;OCT,opticalcoherencetomography;PDT,photodynamictherapy;PED,pigmentepithelialdetachment;RAP,retinalangiomatousproliferation;RP...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第8期日本啓動人類幹細胞臨牀研究
...成的視網膜色素上皮細胞,抑制與年齡相關的黃斑病變(AMD)的病情發展。與年齡相關黃斑病變是導致失明的一種常見原因,在50歲以上人羣中至少有1%的人受其影響。在Takahashi試圖攻克的溼性AMD中,異常的血管侵入破壞了維持...
行業資訊;臨牀快報;克隆與幹細胞研究POT-4用於治療老年黃斑病變啓動一期臨牀
...tentiaPharmaceuticals,Inc.今天宣佈,其用於治療老年黃斑病變(AMD)的候選先導藥物POT-4進入臨牀開發階段。POT-4是一種補體抑制劑,它能阻止可能導致局部炎症、組織損傷和血管生成因子(例如血管內皮生長因子(VEGF))向上調節的補體...
行業資訊;臨牀快報;眼科