中國研究者探討PTEN基因逆轉卵巢上皮性癌細胞耐藥的機制
...癌)順鉑敏感細胞株0V2008及0V2008配對的順鉑耐藥細胞株C13K中的表達,探討轉染PTEN基因能否逆轉C13K細胞對順鉑的耐藥及其相關機制。研究者通過半定量RT-PCR技術和蛋白印跡法檢測0V2008和C13K細胞中PTENmRNA和蛋白的表達。將野生型PTE...
行業資訊;臨牀快報;腫瘤相關RequirementforLeukotrieneB4Receptor1inAllergen-inducedAirwayHyperresponsiveness
...choline,lowergobletcellhyperplasiaintheairways,anddecreasedinterleukin(IL)-13productionbothinvivo,inthebronchoalveolarlavagefluid,andinvitro,afterantigenstimulationoflungcellsinculture.IntracellularcytokinestainingoflungcellsrevealedthatbronchoalveolarlavageIL-13levelsandnumbersofIL-13+/CD4+andIL-13...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第7期胃原發性非霍奇金淋巴瘤13例分析
...以利其早期診斷。方法對經內鏡病理及手術後病理確診的13例胃原發性NHL進行回顧性分析。結果(1)胃原發性NHL臨牀症狀無特殊性,但發病年齡趨向年輕化,本組13例患者最小者僅13歲,30歲以下佔4例,平均發病年齡僅39歲。(2...
合作平臺;在線期刊;中華醫學實踐雜誌;2004年第3卷第10期;臨牀醫學BlockingairwaymucouscellmetaplasiabyinhibitingEGFRantiapoptosisandIL-13transdifferentiationsignals
...activationofEGFRsignalingtoPI3KthatpreventsapoptosisofciliatedcellsandonIL-13signalingthatpromotestransdifferentiationofciliatedtogobletcells.Thus,EGFRblockade(usinganirreversibleEGFRkinaseinhibitordesignatedEKB-569)preventsvirus-inducedincreasesinciliatedandgobletcellswhereasIL-13blockade(usings-IL...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期ReprogrammingofantiviralTcellspreventsinactivationandrestoresTcellactivityduringpersistentviralinfection
...lationbetweenthestrengthoftheTcellresponsesandtheclearanceofHCVinfection(7,13)andthefactthatcontrolofHIVinfectionisassociatedwithincreasedTcellresponsiveness(14).Thus,itisimportanttodevelopstrategiestoboostthehost’sendogenousTcellresponsestocontrolinfection.Tcellinactivationhasbeenrecognizedduring...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期Anisotopicmethodforquantifyingsweetenersderivedfromcornandsugarcane
...m100plant-derivedfoodproductspurchasedfromlocalgrocerystoreswereanalyzedfor13Ccontentbyusingstable-isotopemassspectroscopy.Results:Measurementofnaturalabundanceratiosof13Cto12Cin100off-the-shelffoodsfoundadistinctrangeofvaluesforcorn-andsugarcanederivedfoods,particularlythoserichinhigh-fructos...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第6期ThreoninerequirementofyoungmendeterminedbyindicatoraminoacidoxidationwithuseofL-[1-13C]phenylalanine
...dietarythreonineintakeonphenylalaninefluxandoxidationwasstudiedbyusingL-[1-13C]phenylalanineastheindicatoraminoacid.Results:Theresultsoftwo-phaselinearregressioncrossoveranalysisshowedthatthemeanthreoninerequirement,basedonindicatoroxidation,was19.0mgkg-1d-1withanuppersafeintakeof26.2mg&...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第3期Cysteinekineticsandoxidationatdifferentintakesofmethionineandcystineinyoungadults
...434,MassachusettsInstituteofTechnology,77MassachusettsAvenue,Cambridge,MA02139.E-mail:vryoung{at}mit.edu.ABSTRACTBackground:WepreviouslystudiedmethioninekineticsandoxidationwiththetracerL-[1-13C,methyl-2H3]methionine.Objectives:Wesoughttoexploremethionine-cysteineinterrelationsinadultsbyusingL-[1-13...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年71卷第2期13-2有絲分裂
...要進行DNA複製等準備工作。 (一)前期 前期(圖13-3)的主要事件是:①染色質凝縮,②分裂極確立與紡錘體開始形成,③核仁解體,④核膜消失。 前期最顯著的特徵是染色質通過螺旋化和摺疊,變短變粗,形成光...
醫源資料庫;醫源圖書館;教材類;細胞生物學Genotypicandphenotypicheterogeneityinfamilialmicrocoria
...investigatedusingstandardmarkerstolookforapossiblegenedefectinthechromosome13q31–q32region.Results:Allaffectedmembersofbothfamilieshadpinpointpupilswhichrespondednormallytolightandaccommodation.Noneofthesesubjectsexhibitedanyotherocularabnormality.Theirisofaffectedmembersshowedstromalthinningandap...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第4期