全腦缺血-再灌注對海馬CA1區GAD65表達的影響及意義*
...摘要】目的探討全腦缺血-再灌注對成年大鼠海馬CA1區GAD65表達的影響及意義。方法成年雄性SD大鼠24只,隨機分爲3組:假手術組(SH)、缺血-再灌注3天組(IR-3)及缺血-再灌注7天組(IR-7),每組8只。採用四動脈阻斷法制作全腦...
醫源資料庫;在線期刊;中華現代外科學雜誌;2008年第5卷第1期NeurotensinStimulatesInterleukin-8ExpressionthroughModulationofIBPhosphorylationandp65TranscriptionalActivity:InvolvementofProteinKinaseC
....Inthisstudy,wefirstshowthatNTstimulatesIBphosphorylationanddegradationandp65phosphorylationandtranscriptionalactivity.InhibitionofproteinkinaseC(PKC)activationsignificantlyattenuatesNT-inducedIL-8expression.ThiseffectseemstobemediatedthroughinhibitionofIBphosphorylationanddegradationandbyp65phospho...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期DualPathwaysforNuclearFactorBActivationbyAngiotensinIIinVascularSmoothMuscle
...forvascularinflammation.WereportthatAngIIactivatesNF-Bbyphosphorylatingitsp65subunitviaapathwaymediatedpartiallybyribosomalS6kinase(RSK).Ininvestigatingotherpathway(s)thatmaybeinvolved,wefoundthattheabilityofAngIItoactivateNF-Binmouseembryonicfibroblastissuppressed(70%)eitherbydeletionofIBKinase(IKK...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第11期男性服刑在押犯65例服刑能力鑑定
...性服刑在押犯罹患精神疾病與服刑能力的關係。方法:對65例男性服刑在押犯人的司法鑑定資料進行回顧性統計分析。結果:65例中被鑑定患有精神分裂症、偏執性精神病、躁狂抑鬱症者有46例(70.8%),均被評定爲無服刑能力;...
醫源資料庫;在線期刊;中國民康醫學;2008年第20卷第17期ProtectiveEffectoftheKCNMB1E65KGeneticPolymorphismAgainstDiastolicHypertensioninAgingWomenandItsRelevancetoCardiovascularRisk
...na,SpainUniversitatAute皀omadeBarcelona(J.M.),Barcelona,Spain.AbstractTheE65Kpolymorphisminthe1-subunitofthelarge-conductance,Ca2+-dependentK+(BK)channel,akeyelementinthecontrolofarterialtone,hasrecentlybeenassociatedwithlowprevalenceofdiastolichypertension.Wenowreportthemodulatoryeffectofsexandage...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第12期去勢雄兔乾眼症模型淚腺組織NFκBp65亞基及NOS2表達
【摘要】目的檢測NF²κBp65亞基(NFκBp65)和誘導型一氧化氮合成酶(NOS2)在去勢雄兔乾眼症模型淚腺組織的表達,探討其與乾眼症發病的關係。方法制作6只去勢雄兔乾眼症模型,採用免疫組織化學SP方法對模型兔及6只對照兔淚腺...
醫源資料庫;在線期刊;齊魯醫學雜誌;2009年第24卷第1期PotentialContributionofNF-BinNeuronalCellDeathintheGlutathionePeroxidase-1KnockoutMouseinResponsetoIschemia-ReperfusionInjury
...sientMCAOandreperfusionbyintraluminalsutureblockade.Proteinexpressionofthep65subunitoftranscriptionfactornuclearfactor-B(NF-B)wasexaminedbyimmunohistochemistryandWesternAnalysis.NF-BDNA-proteinactivitywasassessedbyelectrophoreticmobilityshiftassays(EMSA).Wild-typeandGpx1–/–micewereexposedtoMCAOw...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第6期EriocalyxinBInhibitsNuclearFactor-BActivationbyInterferingwiththeBindingofBothp65andp50totheResponseElementinaNoncompetitiveManner
...ucleartranslocationofthetranscriptionfactor.Down-regulationoftheendogenousp65proteinsensitizedthecellstowardtheactionofthecompound.Furthermore,invitrobindingassayssuggestedthatEri-Breversiblyinterferedwiththebindingofp65andp50subunitstotheDNAinanoncompetitivemanner.Insummary,thisstudyrevealsthenovel...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期NovelMechanismofInhibitionofNuclearFactor-BDNA-BindingActivitybyDiterpenoidsIsolatedfromIsodonrubescens
...ferentinhibitoryeffectswereobservedwhenNF-BboundtovariousDNAsequences.Bothp65/p65andp50/p50homodimers,aswellasp65/p50heterodimerassociationwiththeirresponsiveDNA,wereinhibited.KineticstudiesonNF-B-DNAinteractionindicatethatthediterpenoidsdecreasetheBmaxappbuthavenoeffectonKdapp.Thissuggeststhatthisc...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期Caffeinatedbeverageintakeandtheriskofheartdiseasemortalityintheelderly:aprospectiveanalysis
...ndNutritionExaminationSurveyEpidemiologicFollow-upStudy.Theanalysisinvolved6594participantsaged3286ywithnohistoryofCVDatbaseline.Results:Participantsaged65ywithhighercaffeinatedbeverageintakeexhibitedlowerrelativeriskofCVDandheartdiseasemortalitythandidparticipantswithlowercaffeinatedbeveragei...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第2期