CD40L-PositivePlateletsInduceCD40LExpressionDeNovoinEndothelialCells:AddingaLooptoMicrovascularInflammation
...ticlebyWagneretal,inwhichtheauthorselegantlyshowedthatmembraneboundCD154(CD40ligand)expressedbyT-cellscaneffectivelytriggerCD40Lexpressionbyendothelialcells.Moreimportantly,theauthorsdemonstratedafunctionalactivityofendothelium-associatedCD40L,thusrevealinganovelcostimulatoryactivityinmonocyte–end...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第9期CD40分子在腎癌組織中的表達研究
【摘要】目的探討腎癌組織中CD40分子的表達與癌發生浸潤轉移的關係。方法用免疫組織化學二步法(Envision法)對甲醛固定石蠟包埋的腎細胞癌組織(32例)和癌旁組織(10例)中CD40的表達情況進行研究,並分析CD40分子表達水平與腎癌臨...
醫源資料庫;在線期刊;現代泌尿外科雜誌;2008年第12卷第4期TCellAccumulationinBCellFolliclesIsRegulatedbyDendriticCellsandIsIndependentofBCellActivation
...esentirelyasaresultofinteractionwithdendriticcells(DCs).MigrationreliesonCD40-dependentmaturationofDCs,asitdidnotoccurinCD40-deficientmicebutwasreconstitutedwithCD40+DCs.RestorationwasnotachievedbytheactivationofDCswithbacterialactivators(e.g.,lipopolysaccharide,CpG),butwasbytheinjectionofOX40L–hu...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第2期TCellAccumulationinBCellFolliclesIsRegulatedbyDendriticCellsandIsIndependentofBCellActivation
...esentirelyasaresultofinteractionwithdendriticcells(DCs).MigrationreliesonCD40-dependentmaturationofDCs,asitdidnotoccurinCD40-deficientmicebutwasreconstitutedwithCD40+DCs.RestorationwasnotachievedbytheactivationofDCswithbacterialactivators(e.g.,lipopolysaccharide,CpG),butwasbytheinjectionofOX40L–hu...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第2期AtherogenesisinMiceDoesNotRequireCD40LigandFromBoneMarrow–DerivedCells
....bwh.harvard.eduAbstractObjective—RecentresearchsuggestsacentralroleforCD40ligand(CD40L)inatherogenesis.However,therelevantcellularsourceofthisproinflammatorycytokineremainsunknown.TotestthehypothesisthatCD40Lexpressedonhematopoieticcelltypes(eg,macrophages,lymphocytes,platelets)iscrucialtoatherog...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第6期CD40反義RNA的構建及其誘導Balm細胞凋亡
CD40反義RNA的構建及其誘導Balm細胞凋亡中國免疫學雜誌1999年第3期第15卷分子與細胞免疫學作者:王豔華 楊貴貞單位:白求恩醫科大學免疫學教研室,長春130021關鍵詞:CD40反義RNA;Balm細胞;凋亡 中國圖書分類號 R392.11 ...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學Interleukin12p40isrequiredfordendriticcellmigrationandTcellprimingafterMycobacteriumtuberculosisinfection
...udeauInstitute,Inc.,SaranacLake,NY129832GenentechInc.,SouthSanFrancisco,CA94080Migrationofdendriticcells(DCs)tothedraininglymphnode(DLN)isrequiredfortheactivationofnaiveTcells.WeshowherethatmigrationofDCsfromthelungtotheDLNafterMycobacteriumtuberculosis(Mtb)exposureisdefectiveinmicelackinginterleuki...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期十、SP40/40
十、SP40/40 自1982年起,生物科學技術文獻中先後提出一批術語。後經鑑定它們都是蛋白質,且結構類同、功能相近,與補體的末端成分相關。這些成分有不同的名稱:如Clusterin、SGP-2、SP40/40、TRRM-2、T64、GP111、SP80、CLI、apo-J...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學CD40Ligand
...ailGolds017@mc.duke.eduKeyWords:atherosclerosis•inflammation•CD40ligand•stemcells•endothelialprogenitorcellsAtherosclerosisisachronicinflammatoryprocessthataffectsarteriesselectivelyandresultsfromimbalancebetweeninjuryandrepair.Thecomplexetiologyofatherosclerosishasprovedform...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第6期UncoveringthePharmacologyoftheGProtein-CoupledReceptorGPR40:HighApparentConstitutiveActivityinGuanosine5‘-O-(3-[35S]thio)triphosphateBindingS
...ngIncellslackingexpressionofCa2+-mobilizingGproteins,coexpressionofhumanGPR40andGqallowedmedium-andlong-chainfattyacidstoelevateintracellular[Ca2+].Thiswasalsoobservedwhenhumanembryonickidney(HEK)293cellsweretransfectedwithaGPR40-Gqfusionprotein.Thekineticofelevationofintracellular[Ca2+]slowedwithin...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期