TranscriptionalActivationofCYP2C9,CYP1A1,andCYP1A2byHepatocyteNuclearFactor4RequiresCoactivatorsPeroxisomalProliferatorActivatedReceptor-Coa
...r4(HNF4)isakeytranscriptionfactorfortheconstitutiveexpressionofcytochromesP450(P450s)intheliver.However,humanhepatomaHepG2cellsshowahighlevelofHNF4butexpressonlymarginalP450levels.WefoundthattheHNF4-mediatedP450transcriptioninHepG2isimpairedbythelowlevelofcoactivatorsperoxisomalproliferatoractivated...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期InVivoMechanismsofTissue-SelectiveDrugToxicity:EffectsofLiver-SpecificKnockoutoftheNADPH-CytochromeP450ReductaseGeneonAcetaminophenToxicity
...ityinliverandextrahepatictissues.AlthoughitiswellestablishedthatcytochromeP450enzymesplayacriticalroleinthemetabolicactivationofacetaminophen,itisnotyetclearwhetheracetaminophentoxicityinextrahepatictissuesisaconsequenceofhepaticbiotransformation.Theaimofthisstudywastodeterminewhetherextrahepaticace...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期ModulationofUDP-GlucuronosyltransferaseFunctionbyCytochromeP450:EvidencefortheAlterationofUGT2B7-CatalyzedGlucuronidationofMorphinebyCYP3A4
...ronosyltransferase2B7(UGT2B7)-catalyzedmorphineglucuronidationbycytochromeP450(P450)wasstudied.TheeffectsofP450isozymesonthekineticparametersofUGT2B7-catalyzedglucuronidationofthemorphine3-hydroxylgroupwereexaminedbysimultaneousexpressionofUGT2B7andeitherCYP3A4,-1A2,or-2C9inCOS-1cells.Althoughcoexpr...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期c-JunN-TerminalKinasesMediateReactivationofAktandCardiomyocyteSurvivalAfterHypoxicInjuryInVitroandInVivo
...tJNKsarenecessaryforthereactivationofAktafterischemicinjury.WeidentifiedThr450ofAktasaresiduethatisphosphorylatedbyJNKs,andthephosphorylationstatusofThr450regulatesreactivationofAktafterhypoxia,apparentlybyprimingAktforsubsequentphosphorylationby3-phosphoinositideeCdependentproteinkinase.Thereductio...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第1期豬卵透明帶-3α基因在大腸桿菌中的融合表達和鑑定
...。方法 根據重新測序的豬ZP3αcDNA5‘端非編碼鹼基數,pWR450表達質粒家族的pWR450-2被選用來表達β-半乳糖苷酶(LacZ)/ZP3α融合蛋白。帶5‘端非編碼區和信號順序的全長ZP3αcDNA片段,用EcoRⅠ酶切自pZ58質粒,然後被重組插入pWR450-2質粒中...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學CoimmunoprecipitationofUDP-GlucuronosyltransferaseIsoformsandCytochromeP4503A4
...actionsbetweenseveralUDP-glucuronosyltransferase(UGT)isoformsandcytochromeP4503A4.SolubilizedhumanlivermicrosomeswereincubatedwithspecificantibodiestoUGT2B7,UGT1A6,UGT1A1,andCYP3A4,andtheimmunoprecipitateswererunonSDS-polyacrylamidegelelectrophoresis.WesternblotsshowedthatUGT2B7,UGT1A6,UGT1A1,andCYP...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期溫膽湯臨牀應用經驗
...噁心、嘔吐、水食不能進肚,食入即吐,吐淨胃內容物仍乾嘔不止,最後競吐出膽汁及血性黏液。曾靜脈滴注維生素B6等藥物,療效不佳,遂來我院治療。經查尿妊娠試驗(+),診斷爲早孕。診其舌質淡紅,苔薄白,脈滑數。處方...
中醫中藥;中醫臨牀;臨牀討論當歸和紅花對大鼠細胞色素p450異構酶1A2,2C11,2E1and3A1mRNA表達的影響
...icine》上的一篇文章報道,當歸或紅花可以增加細胞色素p450系統CYP1A2和3A1RNA的表達,降低CYP2E1RNA的表達;由這些酶代謝的藥物與當歸或紅花合用,可能會發生藥物間相互作用。雖然中藥如紅花和當歸作爲膳食補充或藥物輔助治療...
行業資訊;臨牀快報;RNA研究PNAS:兩個P450酶基因發生重組導致棉鈴蟲產生抗藥性
...因的位置。這個基因座位後來被發現編碼一個細胞色素P450單加氧酶。這些所謂的細胞色素P450酶(CYP)通過氧化毒素或藥物而讓它們失效。德國馬克斯·普朗克化學生態學研究所科學家NicoleJoußen,研究了棉鈴蟲品種TWB對氰戊菊酯產...
醫藥經濟;生物技術;技術要聞MotexafinGadolinium-InducedCellDeathCorrelateswithHemeoxygenase-1ExpressionandInhibitionofP450Reductase-DependentActivities
...monstratethatinhibitionofHO1reflectsaninteractionofMGdwithNADPH-cytochromeP450reductase,theelectrondonorforHO1,thatresultsindiversionofreducingequivalentsfromhemeoxidationtooxygenreduction.Inaccordwiththismechanism,MGdisalsoaninvitroinhibitorofCYP2C9,CYP3A4,andCYP4A1.InhibitionofHO1byMGdmaycontribut...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期