ProstaglandinE2promotescellsurvivalofglomerularepithelialcellsviatheEP4receptor
...elofGECinjuryandproteinuria.InratswithPAN,glomerularapoptosis,quantifiedascaspase-3activity,aswellasurinaryproteinexcretionweresignificantlyincreased,comparedwithcontrolrats.AdministrationofL-161982inratswithPANfurtherexacerbatedcaspase-3activationandproteinuria.ThusCOX-2anditsproductPGE2mayhaveanti...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第6期RoscovitineTriggersExcitotoxicityinCulturedGranuleNeuronsbyEnhancingGlutamateRelease
...lKCldevelopspontaneousactionpotentialsthatsupportsurvivalthroughN-methyl-D-aspartate(NMDA)receptor-mediatedmechanisms.Furthermore,thecdkinhibitorroscovitineenhancesthecouplingbetweentetrodotoxin-sensitiveactionpotentialsandP/Q-typevoltage-dependentcalciumchannels(VDCCs),therebyconvertingthissurvival...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期Apoptosis-InducingLigand-InducedApoptosisbyUp-RegulationofCaspase-WithoutAlteringChemosensitivity
...nducingligand(TRAIL).ResistancetoTRAILhasbeenlinkedtodeficientexpressionofcaspase-8invitro.Here,wereportonthestatusofcaspase-8expressionintumorsfrompatientswithEwing??ssarcoma,theeffectofinterferon-oncaspase-8expressionandapoptosis,andtheroleofcaspase-8forTRAIL-andchemotherapy-mediatedapoptosisinEwi...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期Pkd1regulatesimmortalizedproliferationofrenaltubularepithelialcellsthroughp53inductionandJNKactivation
...ventsinPkd2WS25/–miceoccurredgraduallyandpostnatally,asinhumanADPKD,whereasPkd1–/–/LZ+micehavePkd1–/–cellsbyinheritance,cystformationinPkd1–/–/LZ+kidneysprogressedmorerapidlythanthatinPkd2WS25/–andhumanADPKDkidneys.However,withPkd1–/–/LZ+mice,wehavetheadvantageofdistinguishingPkd...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期FHL2inhibitstheactivatedosteoclastinaTRAF6-dependentmanner
...hanti-FLAGantibodyandtheimmunoprecipitatesimmunoblottedwithanti-HAantibody.AspecificbandappearsinallTRAF-containingimmunoprecipitates(arrow).(B)HA-taggedFHL2andFLAG-taggedTRAF6werecotransfectedinto293Tcells.Anti-HAantibodywasusedforimmunoprecipitationandanti-FLAGantibodyforimmunoblotting.(C)Thesamec...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期DynamicchangesinMcl-1expressionregulatemacrophageviabilityorcommitmenttoapoptosisduringbacterialclearance
...Mapoptosis.MMP,inhibitedbyantiapoptoticBcl-2familymembers,occursupstreamofcaspaseactivationinmanypathwaysofprogrammedcelldeath(11).MMPischaracterizedbylossofmitochondrialinnertransmembranepotential(°m)andthemitochondrialreleaseofintermembraneproteinssuchascytochromecandapoptosis-inducingfactor(AIF)...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期Roleofmitochondrialglucocorticoidreceptoringlucocorticoid-inducedapoptosis
...tibilitytoGC-inducedapoptosiswasdeterminedbyappearanceofsubdiploidcellsandcaspase3activation.PD1.6and2B4cellsreadilyapoptoseinresponsetoGC,whereasB10,S49,NB4,andJurkatcellsareresistanttoGC-inducedapoptosis(Fig.1,A–C).ItshouldbenotedthattheS49variantusedinthisstudy(25)differsfromtheS49variantdescri...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期ConstitutivelyActiveMutantsoftheHistamineH1ReceptorSuggestaConservedHydrophobicAsparagine-CageThatConstrainstheActivationofClassAGProtein
...hydrophobicaminoacidatposition6.40defines,inacomputationalmodeloftheH1R,theasparaginecagemotifthatrestrainsthesidechainofAsn7.49oftheNPxxYmotiftowardtransmembranedomain(TM6)intheinactivestateofthereceptor.MutationoftheasparaginecageintoAlaorGly,removingtheinterferingbulkyconstraints,increasesthecons...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期Entryofparainfluenzavirusintocellsasatargetforinterruptingchildhoodrespiratorydisease
...stagesatwhichwecouldinterferewiththevirallifecycleandpreventdisease.Afirmgraspofthemolecularmechanismsoftheseeventsisthebasisforunderstandingrespiratorydiseasepathogenesisanddevelopingpotentialapproachestopreventionandtreatment.TheparainfluenzaviruslifecycleHPIVsaremembersoftheRespirovirusandRubulav...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第7期TumorCellPlasticityinUvealMelanoma
...microscope(ProbeArrayScan;AgilentTechnologies,PaloAlto,CA).DataacquisitionwasperformedusingAffymetrixMicroarraySuite5.0.Labelingandhybridizationqualitywascontrolledthroughadditionofexogenouslabelingandhybridizationspikecontrols.Collectedhybridizationimagesweresubjectedtoqualitycontroltoremovearraysf...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第10期