生物化學複習題概要
...極C.PH7時泳向負極D.ph9時泳向正極E.PH9時泳向負極9.含有Gly,Asp,Arg,Cys的混合液,其PI依次分別是5.97,2.77,崐10.76,5.07,在PH10環境中電泳分離這四種氨基酸,自正極開始,電崐泳區帶順序是A.Gly.Asp.Arg.CysB.Asp.Cys.Gly.ArgC.Arg.Gly.Cys.AspD.Cys.Arg.Gly.AspE....
醫源資料庫;醫源習題集;生物化學IsolationandStructure-Activityofμ-ConotoxinTIIIA,APotentInhibitorofTetrodotoxin-SensitiveVoltage-GatedSodiumChannels
...Awasusedforsubsequentcharacterization.RadioligandBindingStudies.125I-TIIIAwaspreparedusing1,3,4,6-tetrachloro-3,6-diphenylglucoluril,storedat4°C,andusedwithin4weeks.125I-TIIIAwaselutedafterTIIIAonaZorbaxSB300C18column(AgilentTechnologies,PaloAlto,CA)asabroadpeakonRP-HPLC,presumablybecauseofthepr...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期ZoledronicAcidActivatestheDNAS-PhaseCheckpointandInducesOsteosarcomaCellDeathCharacterizedbyApoptosis-InducingFactorandEndonuclease-GTranslo
...hep53andRbstatus.Inaddition,theatypicapoptosisinducedbyZolwasindependentofcaspaseactivation,anditwascharacterizedbynuclearalterations,increasedBaxexpression,andreducedBcl-2level.Furthermore,mitochondrialpermeabilitywasup-regulatedbyZolindependentlyofp53inassociationwiththetranslocationofapoptosis-in...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期GeneExpressionChangesduringtheDevelopmentofAcuteLungInjuryRoleofTransformingGrowthFactor
...tedfromevidencethatelevatedlevelsofTGF-1(aswellasTGF-–induciblegenes,suchasprocollagen,typeIII,1)havebeendemonstratedinthelungsofpatientswithacuterespiratorydistresssyndrome(7–9).Furthermore,inmousemodelsofbleomycin-inducedlunginjury,TGF-–induciblegenesareincreasedwithin48h(10).Althoughtheunde...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第12期MolecularInteractionofSerotonin5-HT2AReceptorResiduesPhe339(6.51)andPhe340(6.52)withSuperpotentN-BenzylPhenethylamineAgonists
...SD,DOI,psilocin,and5-MeO-DMT,compoundswithuniqueanddramaticeffectsoncertainaspectsofconsciousness(Nichols2004).Moreover,wehaverecentlyidentifiedafunctionallyselective5-HT2Areceptoragonistthatselectivelyactivatesphosphoinositideturnoveroverproductionofeicosanoids(McLeanetal.,2006a).Akeyaspecttounders...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期MEKK3-mediatedsignalingtop38kinaseandTonEinhypertonicallystressedkidneycells
...4,areupstreamregulatorsofp38inmanycells.Toinvestigatethesesignalingproteinsaspotentialactivatorsofp38inthehypertonicityresponse,wegeneratedstablytransfectedMDCKcellsthatexpressactivatedversionsofMEKK3orMEKK4,utilizedRNAinterferencetodepleteMEKK3,andemployedpharmacologicalinhibitionofp38kinase.MEKK3-...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期Organ-specificrolesfortranscriptionfactorNF-Binreovirus-inducedapoptosisanddisease
...proteinexpression,TUNELstaining,andimmunohistochemicaldetectionofactivatedcaspase-3inthebrainofreovirus-infectedp50+/+(A)andp50–/–(B)mice.Newbornmicewereinoculatedperorallywith104PFUreovirusT3SA+.At12daysafterinoculation,brainswereharvested,paraffinembedded,sectioned,andstainedwithHE,polyclonalr...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期TumorNecrosisFactorandEndothelin-1IncreaseP-GlycoproteinExpressionandTransportActivityattheBlood-BrainBarrier
...acomplex,time-dependentmanner.Intheseexperiments,wechosetomeasureexpressionasprotein,becausethiscorrelateswithtransportfunction.TheinitialrapidreductionintransportactivityfirstdescribedbyHartzetal.(2004,2006),wasfollowedbya2-to3-hplateauatthereducedactivitylevelandthenbyarapidincrease.After6h,bothtr...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期StructuralbasisforthefunctionandregulationofthereceptorproteintyrosinephosphataseCD45
...elenomethionine.Proteintyrosinephosphorylationisakeymechanismfornearlyeveryaspectofcellregulation,rangingfromcellsurvivalandproliferationtoapoptoticcelldeathinmulticellulareukaryotes.Tyrosinephosphorylationitselfisregulatedbyaconcertedactionofproteintyrosinekinasesandproteintyrosinephosphatases(PTPs...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第3期Cholesteroltargetingalterslipidraftcompositionandcellsurvivalinprostatecancercellsandxenografts
...rdetergent-resistant,liquid-orderedstructure.Caveolae(“littlecaves“)areaspecializedtypeofraftcharacterizedby50-to100-nminvaginationsintheplasmamembrane(2).Thedistinctive,pittedcytomorphologyexhibitedbycaveolarraftsarisesfromthestructuralcontributionofmembraneproteinsofthecaveolinfamily(3,4).Cave...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期