MultipleP2Xreceptorsareinvolvedinthemodulationofapoptosisinhumanmesangialcells:evidenceforaroleofP2X
...ndlateapoptosis,asmeasuredbyAnnexinV/propidiumiodide-basedflowcytometryandcaspase-3activation.BothphenomenawerepreventedbytheP2Xantagonistoxidized-ATP.2‘,3‘-O-(4-benzoylbenzoyl)adenosine5‘-triphosphate(BzATP)waslesseffectivethanATP,whereas1[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第5期TransformingGrowthFactor-1ImpairsEndothelin-1-MediatedContractionofBrainVesselsbyInducingMitogen-ActivatedProtein(MAP)KinasePhosphatase-1andI
...)(Niwaetal.,2000)beforeET-1stimulation.Inhibitionofp38MAPKorpERKactivationwasperformedoncellskeptovernightinserum-freeconditionandpretreated(1h)withSB-203580(25µM)orU-0126(10µM)beforestimulationwithET-1orPE.ThecontributionofMKP-1orproteinkinaseC(PKC)inTGF-1regulationofp38MAPK/HSP27activi...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期LinkageandAssociationBetweenDistinctVariantsoftheAPOA1/C3/A4/A5GeneClusterandFamilialCombinedHyperlipidemia
.../A5geneclusterwereovertransmittedinFCHL(P=0.004and0.007,respectively).ThiswaspairedwithreducedtransmissionofthecommonAPOA1/C3/A4/A5haplotype(frequency0.4461)toaffectedsubjects(P=0.012).TheAPOA5c.56Ggenotypeaccountedfor7.3%to13.8%ofthevarianceinplasmatriglyceridelevelsinprobands(P0.004).TheAPOC3c.386...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第1期JX401,Ap38InhibitorContaininga4-BenzylpiperidineMotif,IdentifiedviaaNovelScreeningSysteminYeast
...dthemechanismofactionofthetargetareknown.However,theapproachislimitedinmanyaspects(Blundell,1996;Blundelletal.,2002;Daviesetal.,2002;Nobleetal.,2004).Anotherapproachisbasedonthescreeningofcombinatorialchemistrylibrariescomposedofhundredsofthousandsofsmallmolecules(BroachandThorner,1996;Hogan,1996).I...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第10期酶活性測定條件的選擇和限定
...最大反應速度也有差異,從圖中可以看出選用磷酸鹽與L-Asp和L-Ala的混合緩衝液最佳,因爲它的pH值受溫度影響較小。類似現象在大多數酶都能圖8-21各種緩衝液的溫度及pH的關係觀察到,僅是程度不同,其中以鹼性磷酸酶活性受到...
藥品天地;專業藥學;實驗技術;生化實驗;酶學實驗AcuteregulationofOAT3-mediatedestronesulfatetransportinisolatedrabbitrenalproximaltubules
...me-dependentmanner.Thisinhibitionwasreducedby100nMbisindoylmaleimideI(BIM),aspecificPKCinhibitor.The1-adrenergicreceptoragonistphenylephrinealsoinhibitedESuptake,andthiseffectwasreducedbyBIM.TheseresultssuggestthatPKCactivationdownregulatesOAT3-mediatedorganicaniontransport.Incontrast,epidermalgrowt...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期Long-termtreatmentwithcyclosporinedecreasesaquaporinsandureatransportersintheratkidney
....Fractionalexcretionofsodium(FENa)andTcWwerecalculatedusingstandardformulasaspreviouslydescribedbyLietal.(15).Bloodsampleswereobtainedtoevaluateserumcreatinine(Scr).Thecreatinineclearancerate(Ccr)wascalculatedusingastandardformula.WholebloodCsAlevelsweremeasuredbymonoclonalradioimmunoassay(Incstar,S...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第7期1-IntegrinsintheprimaryciliumofMDCKcellspotentiatefibronectin-inducedCa2+signaling
...gG(MolecularProbes,Eugene,OR),EGTA,probenecid,neuraminidase,andGlu-Arg-Gly-Asp-Ser-Pro-Lys-peptide(Sigma,St.Louis,MO),anti-1-integrin(MAB2000,AB1952),anti-3-integrinantibody(AB1920),andanti-5-integrinantibody(AB1949;ChemiconInternational,Temecula,CA).Fluorescence-taggedpeanutandSambucusnigraagglutin...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期TheXenobiotic-MetabolizingEnzymesArylamineN-AcetyltransferasesinHumanLensEpithelialCells:InactivationbyCellularOxidantsandUVB-InducedOxidative
...revealedthepresenceofaconservedcysteineprotease-likecatalytictriad(Cys-His-Asp).ThisactivesitecysteineresidueiscriticalforNATactivity(DupretandGrant,1992),anditsoxidativemodificationbyoxidantsleadstotheinactivationofNATenzymes(Mattanoetal.,1989;Atmaneetal.,2003;Dairouetal.,2004).Thehumanlenshasasing...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期ChroniclymphocyticleukemiaBcellscontainanomalousLyntyrosinekinase,aputativecontributiontodefectiveapoptosis
...,5peripheralbloodsamples,and40B-CLLsamples.TheanalysisoftheotherSrckinaseswasperformedwith10CLLsamples.(B)TheanalysisofLynimmunolocalizationwasperformedbyconfocalmicroscopyin3differentnormaland10B-CLLsamples.Originalmagnification,x60.(C)TheanalysisofLynand?-actinmRNAexpressionwasperformedbyNorthernb...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期