MalariaBloodStageSuppressionofLiverStageImmunitybyDendriticCells
...tectioninducedagainsttheliverstageofthedisease,thefeasibilityofvaccinationwasprovenbyimmunizationofmiceandhumanswithirradiatedPlasmodiumsporozoitesthatinduceprotectionagainstthisstageoftheparasite(4,5).ProtectionismediatedbyhighCD8+Tcellresponsesspecificagainstinfectedhepatocytes(6).Plasmodiumisextr...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第2期LipoproteinLipaseS447X
...edextensivelyconcerningpointmutationsinexon2and6,causingthesubstitutionofanasparticacidtoanasparagineresidueatposition9(D9N),andanasparaginetoaserineresidueatposition291(N291S),respectively.Thesemutationsoccurathighfrequenciesinthegeneralpopulation(upto5%)andareassociatedwithelevatedTGs,decreasedhig...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第6期ModulationoftheCa2PermeableCationChannelTRPV4byCytochromeP450EpoxygenasesinVascularEndothelium
...respondtoawidevarietyofphysical,thermal,andchemicalstimuli.Initially,TRPV4wasputforwardasamechanosensororosmosensor.Thiswasbasedonthefindingthatthechannelopensinresponsetohypotoniccellswelling3eC8aswellasshearstress.9Indeed,micelackingtheTRPV4geneshowadisturbanceofosmoregulationandanincreasedmechani...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第10期RenalvascularandtubulointerstitialinflammationandproliferationinCyp1a1-Ren2transgenicratswithinducibleANGII-dependentmalignanthypertension
...ratedbyinsertingthemouseRen2reningeneintothegenomeoftherat.ThepresentstudywasperformedtoassessrenalmorphologicalchangesoccurringduringthedevelopmentofANGII-dependentmalignanthypertensionintheserats.MaleCyp1a1-Ren2rats(n=10)werefednormalratfoodcontainingindole-3-carbinol(I3C;0.3%)for10daystoinducemal...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第6期CYP2C9Genotype-DependentEffectsoninVitroDrug-DrugInteractions:SwitchingofBenzbromaroneEffectfromInhibitiontoActivationintheCYP2C9.3Variant
...siteswithsufficientspaceforbenzbromaronebindingintheenzymewhenflurbiprofenwaspositionedclosesttotheheme.Iftheclosedconformationof2C9.3isstructurallysimilarto2C9.1,asexpectedfortheconservativeI359Lmutation,thenthedynamicsofbenzbromaronebindingmayaccountfortheswitchingofdruginteractioneffects.Inconclu...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第3期Neurokinin-3Receptor-SpecificAntagonistsTalnetantandOsanetantShowDistinctModeofActioninCellularCa2+MobilizationbutDisplaySimilarBindingKine
...oversial.ItdisplaysalinearSchildplotwithaslopeofunityinsenktide[(succinyl-[Asp9,MePhe8])-SP(6-13)]-inducedcontractionofrabbitirissphinctermuscles,indicatingcompetitiveantagonism,butthiscompetitivepatterndoesnotholdwhenotheragonists,suchas[MePhe7]NKBor[Pro7]NKB,areusedinthesameprocedure(Giardinaetal....
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期Renalendothelialdysfunctionandimpairedautoregulationafterischemia-reperfusioninjuryresultfromexcessnitricoxide
...EC50wasincreased,andendothelium-derivedhyperpolarizingfactor(EDHF)activitywaspreservedinB60kidneys.IncreasingangiotensinIIconcentrationrestoredautoregulationandincreasedrenalvascularresistance(RVR)inB60kidneys;thisfacilitatedautoregulation,andtheincreaseinRVRwasabolishedby100µMfurosemide.Autor...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期CombinatorialcontrolofthebradykininB2receptorpromoterbyp53,CREB,KLF-4,andCBP:implicationsforterminalnephrondifferentiation
...edoligodeoxynucleotideswere5‘end-labeledwith[-32P]dATPusingT4kinaseforuseasprobes.DNA-proteincomplexeswereresolvedona5%polyacrylamidegelwith0.25xTBEbufferat200Vfor12h,andthegelwastransferredtoanddriedonWhatmanpaperandexposedtoX-rayfilm.Sequencesofoligonucleotides(double-stranded)usedforEMSAareshow...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第5期IdentificationofaNovelLigandBindingResidueArg38(1.35)intheHumanGonadotropin-ReleasingHormoneReceptor
...ntofdisorderssuchasreproductivecancers,precociouspuberty,andendometriosis(Casper,1991).Forwelloveradecade,Gq/11hasbeenknowntobethepredominantG-proteincoupledtothemammalianGnRHreceptorsinvariouscellularenvironments(Kaiseretal.,1997;Rufetal.,2003).BindingofagonisttotheGnRHreceptortriggersgonadotropins...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期PresenceofActivatableShigaToxinGenotype(stx2d)inShigaToxigenicEscherichiacolifromLivestockSources
...on).Bothstrandsofeachstx2doperonampliconwerecompletelysequenced.SequencingwasperformedwithaBigDyeCycleSequencingkitfollowingtheinstructionsofthemanufacturerandanABI377fluorescentsequencer(AppliedBiosystems,FosterCity,Calif.)attheAustralianGenomeResearchFacility,UniversityofQueensland,Brisbane,Austra...
醫源資料庫;在線期刊;微生物臨牀雜誌;2003年第41卷第8期