BreakpointsforPredictingPseudomonasaeruginosaSusceptibilitytoInhaledTobramycininCysticFibrosisPatients:UseofHigh-RangeEtestStrips
...eraltobramycinlevels,particularlyagainstPseudomonasaeruginosa.ConventionalClinicalandLaboratoryStandardsInstitute(CLSI;formerlyNationalCommitteeforClinicalLaboratoryStandards)breakpointsonlyconsiderparenterallevelsanddonottakeintoaccountthesehighantimicrobialconcentrations.TheSpanishAntibiogramCommi...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期IL-7receptorsignalingisnecessaryforstagetransitioninadultBcelldevelopmentthroughup-regulationofEBF
...ctorEBFanditstargetgenes,whichformatranscriptionfactornetworkindeterminingBlineagespecification.EBFexpressionisrestoredinIL-7–/–pre–pro-BcellsuponIL-7stimulationorinIL-7R–/–pre–pro-BcellsbyactivationofSTAT5,amajorsignalingmoleculedownstreamoftheIL-7Rsignalingpathway.Furthermore,enforcedE...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期InfluenceofPlasmaViremiaonDefectsinNumberandImmunophenotypeofBloodDendriticCellSubsetsinHumanImmunodeficiencyVirus1InfectedIndividuals
Divisionsof1InfectiousDiseasesand2ClinicalImmunology,DepartmentofMedicine,and3DepartmentofPreventiveMedicineandBiometrics,UniversityofColoradoHealthSciencesCenter,DenverReceived17April2002;revised10September2002;electronicallypublished13December2002.Dendriticcells(DCs)arepostulatedtobeinvolvedintran...
醫源資料庫;在線期刊;傳染病學雜誌;2003年第187卷第1期IKK/NF-Bsignaling:balancinglifeanddeath–anewapproachtocancertherapy
...ofMedicine,UCSD,LaJolla,California,USA.AbstractIBkinase/NF-B(IKK/NF-B)signalingpathwaysplaycriticalrolesinavarietyofphysiologicalandpathologicalprocesses.OnefunctionofNF-Bispromotionofcellsurvivalthroughinductionoftargetgenes,whoseproductsinhibitcomponentsoftheapoptoticmachineryinnormalandcancerousc...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期ofFibulin-ExpressionIsAssociatedwithBreastCancerProgression
【摘要】Fibulin-2,anextracellularmatrixproteinexpressedbynormalepithelia,wasfoundtobedown-regulatedinseveralbreastcancercelllines.Fibulin-2proteinexpressionwasalsodecreasedinbreastcancertissuesamplesasevaluatedbyimmunohistochemistry.ReintroductionofFibulin-2intobreastcancercelllinesthatdonotexpr...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第5期ComparisonofImmunohistochemistryandVirusIsolationforDiagnosisofWestNileVirus
...esultsindicatethatvirusisolationandimmunohistochemistryareapproximatelyequalintheirabilitytodetectWestNilevirus.TEXTWestNilevirus(WNV)isamemberofthefamilyFlaviviridae,genusFlavivirus.Itistransmittedbymosquitovectorstoavarietyofavianhostsandincidentallytohorsesandhumans(1).WestNileviruswasfirstreport...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第6期DistributionoftccPinClinicalEnterohemorrhagicandEnteropathogenicEscherichiacoliIsolates
...edKingdomStateKeyLaboratoryforInfectiousDiseasePreventionandControl,NationalInstituteforCommunicableDiseasesControlandPrevention,ChinaCDC,Beijing,ChinaDepartmentofMicrobiologyandImmunology;UniversityofMelbourneMurdochChildrensResearchInstitute,RoyalChildren‘sHospital,Victoria,AustraliaDepartamento...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期IL-2productionindevelopingTh1cellsisregulatedbyheterodimerizationofRelAandT-betandrequiresT-betserineresidue508
...sorcellsintoeffectorcells.Initialhigh-levelIL-2productionisfollowedbyitsdecline,andtheconcomitantinductionofcytokinesthataretypicalofthedifferentiatedstate.AlthoughthefactorsthatareresponsiblefortheearlyinductionofIL-2arewelldefined,themechanismsthatareresponsibleforitsdown-regulationinlaterstagesof...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第9期薑黃素的抗癌作用及機理的研究進展
...抗HIV病毒等,且毒性很低。研究表明,薑黃素對多種腫瘤細胞均具有明顯的抑制作用,本文謹從誘發腫瘤細胞凋亡、阻斷腫瘤細胞的生長信號傳導通路和抑制腫瘤血管生成三方面探討薑黃素的抗腫瘤作用及機制。近年來,植物來...
合作平臺;在線期刊;中華醫學研究雜誌;2004年第4卷第7期;綜述基於最小二乘支持向量機的色譜指紋譜預測銀杏葉總抗氧化活性
...,可構造不同的支持向量機,常用的核函數有:線性核(LIN)、徑向基核(RBF)和多項式核(POLY)。 2.2最小二乘支持向量機的參數優化 由式(8)和式(9)可知,LSSVM需要優化的參數包括γ和特定核函數的參數,如採用徑向基核函數,...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文