Mitochondrialaldehydedehydrogenase-2(ALDH2)Glu504Lyspolymorphismcontributestothevariationinefficacyofsublingualnitroglycerin
...tiveNOortheNOcongenerS-nitrosothiol,whichcanactivatecyclicGMP(cGMP)andconsequentlyrelaxvascularsmoothmuscle(1-3).Theexactmechanismunderlyingitsbiotransformationremainedcontroversial(4,5)untilStamlerandcoworkers(2)showedthatmitochondrialaldehydedehydrogenase-2(ALDH2)istheenzymeprincipallyresponsiblef...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期InvivomeasurementsdocumentthedynamiccellularkineticsofchroniclymphocyticleukemiaBcells
...iclabelingmethodtomeasureB-CLLcellkineticsinvivo.Nineteenpatientsdrankanaliquotofdeuteratedwater(2H2O)dailyfor84days,and2HincorporationintothedeoxyribosemoietyofDNAofnewlydividedB-CLLcellswasmeasuredbygaschromatography/massspectrometry,duringandafterthelabelingperiod.Birthrateswerecalculatedfromthek...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期IKK/NF-Bsignaling:balancinglifeanddeath–anewapproachtocancertherapy
...F-B,mostlythroughIBkinase–dependent(IKK-dependent)phosphorylationandsubsequentdegradationofIBproteins.TheliberatedNF-Bdimersenterthenucleus,wheretheyregulatetranscriptionofdiversegenesencodingcytokines,growthfactors,celladhesionmolecules,andpro-andantiapoptoticproteins(1,2).TheIKKcomplexconsistsof...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期TheimpactofDMonMHCclassII–restrictedantigenpresentationcanbealteredbymanipulationofMHC–peptidekineticstability
...gglysozyme;SWM,spermwhalemyoglobin.Stimulationofantigen-specificCD4TcellsrequiresthepresentationofimmunogenicpeptideepitopesinassociationwithMHCclassIImoleculesonthesurfaceofprofessionalAPCs.TheassemblyandexportoftheseclassII–peptidecomplexesisaregulatedmultistepprocess,culminatingintheexchangeofC...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第5期MassiveanddestructiveTcellresponsetohomeostaticcueinCD24-deficientlymphopenichosts
...fCD24ondendriticcells(DCs).Interestingly,althoughCD24expressioninTcellsisrequiredforoptimalhomeostaticproliferationinthewild-type(WT)host,micelackingCD24onallcelltypesstillmounthigherhomeostaticproliferationthantheWTmice.Thus,alackofCD24inthenon–ThostcellsbypassedtherequirementforTcellexpressionof...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期PhenylglycineandSulfonamideCorrectorsofDefectiveF508andG551DCysticFibrosisTransmembraneConductanceRegulatorChloride-ChannelGating
...essingF508-CFTRandafluorescenthalideindicator(yellowfluorescentprotein-H148Q/I152L)afterF508-CFTRrescueby24-hcultureat27°C.Secondaryanalysisandtestingof1000structuralanalogsyieldedtwonovelclassesofcorrectorsofdefectiveF508-CFTRgating(“potentiators“)withnanomolarpotencythatwereactiveinhumanF508a...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期生化實驗講義(理論部分)四--電泳技術(一)
...發現正極玻璃管中原有的水層變混濁,即帶負電荷的粘土顆粒向正極移動,這就是電泳現象。1909年Michaelis首次將膠體離子在電場中的移動稱爲電泳。他用不同pH的溶液在U形管中測定了轉化酶和過氧化氫酶的電泳移動和等電點。19...
藥品天地;專業藥學;實驗技術;色譜技術;色譜入門高能X射線對肺腺癌A549細胞ERCC1表達的影響
...美國)爲1∶50濃縮液。ERCC1陽性表現爲細胞核內出現棕黃色顆粒沉澱。照射前及照射後各時間點各選1張細胞分佈比較均勻、細胞稠密適當的細胞爬片。每張爬片隨機選取5個高倍視野,每個視野計數100個細胞,計算陽性細胞佔細胞...
醫源資料庫;在線期刊;齊魯醫學雜誌;2010年第25卷第3期MastocytosisinmiceexpressinghumanKitreceptorwiththeactivatingAsp816Valmutation
...stituteforCancer,13009Marseille,France3CentreNationaldelaRechercheScientifiqueUMR8147,CellularandMolecularHematologyLaboratory,PharmacyUniversity,75006Paris,France4CellularandMolecularAllergologyLaboratory,PasteurInstitute,75015Paris,France5ImmunologyLaboratory,RangueilUniversityHospital,31000Toulou...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第12期第五章 高頻電療法--第一節 概論
...的電解質離子(A)(如Na+、K+、C1+、OH-等)及帶電膠體顆粒(B)(蛋白質分子顆粒)隨電場正負變化發生快速振盪、即爲傳導電流。微粒相互衝撞磨擦引起歐姆耗損而產生熱能。 高頻電流→導體部分→離子及帶電膠體振動...
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