寧夏漢族人羣細胞色素P4501B1SNPrs1056836分佈研究
...即外顯子2上的Arg48Gly、Ala119Ser和外顯子3上的1294位C→G(Leu432Val)即rs1056836、1358A→G(Asn453Ser),其等位基因頻率具有種族差異[4,5]。外顯子3上有三個多態位點導致了氨基酸的改變,而453A→G和443C→G比較少見,故432C→G(CY...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第10期Real-TimeAnalysisofAgonist-InducedActivationofProtease-ActivatedReceptor1/Gi1ProteinComplexMeasuredbyBioluminescenceResonanceEnergyTransferin
...lyclonalrabbitanti-Gi1/2antibody(Lledoetal.,1992)andTRAP-14peptide(Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2)weregenerousgiftsfromDr.V.Homburger(IGF,Montpellier,France);SCH79797,Thr-Phe-Leu-Leu-Arg-NH2(TFLLR),andSer-Leu-Iso-Gly-Arg-Leu-NH2(SLIGRL)peptideswerefromTocrisCooksonInc.(E...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第5期HelixIof-ArrestinIsInvolvedinPostendocyticTraffickingbutIsNotRequiredforMembraneTranslocation,ReceptorBinding,andInternalization
...athicandpotentiallyamphitropic(membrane-targeting),withhydrophobicresidues(Leu100,Leu104,andLeu108,arr1numbering)alignedononesideofthehelixandpositivecharges(Arg99,Arg103,Lys106,andLys107)alignedontheoppositeside(Hanetal.,2001).Thissuggestsapossibleroleinmembranetargetingandfacilitationofreceptorint...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第2期ResiduesMet89andSer160intheHumanEquilibrativeNucleosideTransporter1AffectItsAffinityforAdenosine,Guanosine,S6-(4-Nitrobenzyl)-mercaptopurine
...ibitionbyNBMPRof[3H]adenosinetransportbywild-type(WT),single,ordouble(e.g.,Leu/Asp)mutanthENT1-expressingyeast.TheIC50values(mean±S.D.;n=3)ofdipyridamoleanddilazepwereestimatedbynonlinearregressionanalysisoftheinhibitionof[3H]adenosinetransportbyhENT1wild-type(WT),single,orMet89Cys/Ser160Cys(cystei...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期Subtype-SpecificAffinityforCorticosteroneofRatOrganicCationTransportersrOCT1andrOCT2DependsonThreeAminoAcidswithintheSubstrateBindingRegi
...noacidsinrOCT2decreasedtheaffinityforcorticosterone.Theseaminoacids(Ala443,Leu447,andGln448inrOCT1andIle443,Tyr447,andGlu448inrOCT2)areprobablylocatedwithinthesubstratebindingregionbecauseinrOCT1mutants,theKmvaluesforuptakeoftetraethylammonium(TEA)and1-methyl-4-phenylpyridinium(MPP)weredecreasedinpa...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期3-2-2遺傳密碼的破譯
...polyC結合。還有GUU可促進Val-tRNA(纈氨酰-tRNA)結合,UUG促進Leu-tRNA(亮氨酰-tRNA)結合等。雖然所有64個三核苷酸(密碼子)都可按設想的序列合成,但並不是全部密碼子均能以這種方法決定因爲有一些三核苷酸序列與核糖體結合並不象UUU...
醫源資料庫;醫源圖書館;教材類;分子生物學BiologicalAssessmentofAspirinEfficacyonHealthyIndividuals
...creatinine).Finally,therewasnoinfluenceofplateletglycoproteinIIb/IIIa(Pro33Leu),plateletglycoproteinIa/IIa,(C807T),andFXIII(Val34Leu)polymorphismsontheefficacyofaspirin.However,thecyclooxygenase(Cox)-150Talleleassociatedwithhigherlevelof11-dTxB2,bothbeforeandafteraspirin.Moreover,theCox-2–765Cvari...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第2期StructuralBasisforEpibatidineSelectivityatDesensitizedNicotinicReceptors
...th104225,increasedepibatidineaffinity30-foldrelativeto103225,suggestingthatLeu104anditsequivalentTyr106aremajordeterminantsofepibatidineselectivity.ToconfirmthatLeu104andTyr106contributetoagonistselectivity,weconstructedsubunitscontainingpointmutationsoftheseresidues(Fig.4).BothL104YandY106Lproduced...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期Insulin-LikeGrowthFactor-IRegulatesProliferationandOsteoblasticDifferentiationofCalcifyingVascularCellsviaExtracellularSignal-RegulatedProtein
...humanplateleteCderivedgrowthfactor(PDGF-BB)wasfromPeprotech.[Arg3]IGF-Iand[Leu24]IGF-IwerefromGroPepBioreagents.CellCultureCVCs,isolatedfrombovineaorticmedialexplants,wereculturedasdescribed.3TreatmentswereadministeredinDMEMcontaining5%FBS(HycloneLabs)1dayafterplating(atsubconfluence),andfreshmediaw...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第3期ASingleResidueintheS6TransmembraneDomainGovernstheDifferentialFlecainideSensitivityofVoltage-GatedPotassiumChannels
...ifferencesamongthesefourvoltage-gatedK+-channelsaredeterminedbywhetheranisoleucineoraleucineispresentataspecificaminoacidlocation.Voltage-gatedK+-channelsoftheShakerfamilyplayanimportantroleingoverningcardiacexcitability(RodenandGeorge1997;Snyders,1999).AvarietyofantiarrhythmicagentstargetShaker-bas...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期