N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide(CPPHA)ActsthroughaNovelSiteasaPositiveAllostericModulator
...鍵詞】Group1Recentstudiessuggestthatanovelpositiveallostericmodulator(PAM)ofthemetabotropicglutamatereceptor(mGluRs),mGluR5,termed4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide(VU-29),potentiatesmGluR5responsesbyactionsatasitethatisoverlappingwiththebindingsiteof2-methyl-6-(phenylethynyl)pyrid...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期Tamm-HorsfallglycoproteinlinksinnateimmunecellactivationwithadaptiveimmunityviaaToll-likereceptor-4–dependentmechanism
...mineTFactivity.Theresultsarerepresentativeof3independentexperiments.(D)LPS,Pam3Cys(P3C),THPisolatedbystandardNaClprecipitation(THP),THPisolatedbyNaClprecipitationandultracentrifugation(THP-UC),andTHPisolatedbyNaClprecipitation,ultracentrifugation,anddiatomaceousearthfilter(THP-DEF)wereaddedtoC57BL/6...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期全身炎症反應綜合徵和多器官功能不全綜合徵的研究現狀
...效清除循環中的TNF-α、IL-1、IL-6、PAF等,明顯優於PS膜、PAM膜的效果[14]。對於淨化方式選擇,現多傾向於採取聯合方式血液淨化治療[15]:(1)血液灌流+血液透析(hemoperfusion+hemodialy-sis):既能吸附各種特異和非特異性毒素,...
合作平臺;在線期刊;中華實用醫藥雜誌;2005年第5卷第13期;綜述DevelopmentofImmunoglobulinANephropathy-LikeDiseaseinß--Galactosyltransferase-I-DeficientMice
...ylinandeosin(H&E),periodicacid-Schiff(PAS),periodicacid-methenamine-silver(PAM),andMasson??strichromestainingusingstandardmethods.Thedegreeofglomerularlesionswasclassifiedintominorglomerularabnormality,segmentallesion,andgloballesionbyinvestigatingPAS-stainedsections.Thesegmentallesionincludessegmen...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第2期NOD2/CARD15在克羅恩病發生髮展中的作用
...協同作用。有學者發現NOD2與TLR2在各自的特異性配體MDP及Pam3Cys的同時刺激下誘導炎症因子TNF-α、IL-β及抗炎因子IL-10明顯增加,而存在L1007fs變異時,這一協同效應則消失。類似的協同作用還見於NOD2與TLR4及TLR3之間[1]。亦...
醫源資料庫;在線期刊;中華現代內科學雜誌;2007年第4卷第4期ComputationalIdentificationofKeyBiologicalModulesandTranscriptionFactorsinAcuteLungInjury
...PS,orMV+LPSrelativetocontrolwereclusteredusingthepartitioningaroundmedoids(PAM)algorithm(9).Allmicroarraydata,incompliancewithMinimumInformationaboutaMicroarrayExperiment,areavailableattheGEOwebsite(http://www.ncbi.nlm.nih.gov/projects/geo/,queryGSE2411).GeneOntologyAnalysisGeneannotationofallprobes...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第6期Flavonoids:areviewofprobablemechanismsofactionandpotentialapplications
...ificResearch(fellowshiptoRJN).3Reprintsnotavailable.AddresscorrespondencetoPAMvanLeeuwen,DepartmentofSurgery,VrijeUniversiteitMedicalCenter,POBox7057,1007MBAmsterdam,Netherlands.E-mail:pam.vleeuwen{at}azvu.nl.ABSTRACTTheaimofthisreview,asummaryoftheputativebiologicalactionsofflavonoids,wastoobtainaf...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年74卷第4期Acontrolledtrialofreducedmealfrequencywithoutcaloricrestrictioninhealthy,normal-weight,middle-agedadults
...%and7.2%,respectively.PhysicalactivityassessmentPhysicalactivitymonitoring(PAM)wasassessedwiththeuseoftheActigraphaccelerometer(MTIAM71641.2;ManufacturingTechnologyInc,FortWaltonBeach,FL)overthecourseof7dtoobtaintheaveragedailyandweeklyactivitycounts.Measurementswereobtainedduringweek2(baselin...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第4期EffectofLactobacillusplantarum299voncardiovasculardiseaseriskfactorsinsmokers
...icine,ulPowstañwWlkp72,70-111Szczecin,Poland.E-mail:mnarusze{at}sci.pam.szczecin.pl.ABSTRACTBackground:Theshort-chainfattyacidsformedinthehumancolonbythebacterialfermentationoffibermayhaveanantiinflammatoryeffect,mayreduceinsulinproduction,andmayimprovelipidmetabolism.Wepreviouslyshowedinhype...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第6期FunctionalandImmunologicalCharacterizationofaDuffyBindingLikeDomainfromPlasmodiumfalciparumErythrocyteMembraneProtein1ExpressedbyaPlacental
...eplacentaprobablycontributestothepathogenesisofpregnancy-associatedmalaria(PAM)[6].Severalvargeneshavebeenshowntofulfilatleast1ofthecriterianecessarytoqualifyasaPAM-causinggene,suchasup-regulationinCSA-bindingparasites,morefrequenttranscriptioninplacentalparasitesthaninparasitesfromchildren,surfacee...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第19期