3-2-2遺傳密碼的破譯
...polyC結合。還有GUU可促進Val-tRNA(纈氨酰-tRNA)結合,UUG促進Leu-tRNA(亮氨酰-tRNA)結合等。雖然所有64個三核苷酸(密碼子)都可按設想的序列合成,但並不是全部密碼子均能以這種方法決定因爲有一些三核苷酸序列與核糖體結合並不象UUU...
醫源資料庫;醫源圖書館;教材類;分子生物學BiologicalAssessmentofAspirinEfficacyonHealthyIndividuals
...creatinine).Finally,therewasnoinfluenceofplateletglycoproteinIIb/IIIa(Pro33Leu),plateletglycoproteinIa/IIa,(C807T),andFXIII(Val34Leu)polymorphismsontheefficacyofaspirin.However,thecyclooxygenase(Cox)-150Talleleassociatedwithhigherlevelof11-dTxB2,bothbeforeandafteraspirin.Moreover,theCox-2–765Cvari...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第2期StructuralBasisforEpibatidineSelectivityatDesensitizedNicotinicReceptors
...th104225,increasedepibatidineaffinity30-foldrelativeto103225,suggestingthatLeu104anditsequivalentTyr106aremajordeterminantsofepibatidineselectivity.ToconfirmthatLeu104andTyr106contributetoagonistselectivity,weconstructedsubunitscontainingpointmutationsoftheseresidues(Fig.4).BothL104YandY106Lproduced...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期Insulin-LikeGrowthFactor-IRegulatesProliferationandOsteoblasticDifferentiationofCalcifyingVascularCellsviaExtracellularSignal-RegulatedProtein
...humanplateleteCderivedgrowthfactor(PDGF-BB)wasfromPeprotech.[Arg3]IGF-Iand[Leu24]IGF-IwerefromGroPepBioreagents.CellCultureCVCs,isolatedfrombovineaorticmedialexplants,wereculturedasdescribed.3TreatmentswereadministeredinDMEMcontaining5%FBS(HycloneLabs)1dayafterplating(atsubconfluence),andfreshmediaw...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第3期ASingleResidueintheS6TransmembraneDomainGovernstheDifferentialFlecainideSensitivityofVoltage-GatedPotassiumChannels
...ifferencesamongthesefourvoltage-gatedK+-channelsaredeterminedbywhetheranisoleucineoraleucineispresentataspecificaminoacidlocation.Voltage-gatedK+-channelsoftheShakerfamilyplayanimportantroleingoverningcardiacexcitability(RodenandGeorge1997;Snyders,1999).AvarietyofantiarrhythmicagentstargetShaker-bas...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期AminoAcidsCriticalforSubstrateAffinityofRatOrganicCationTransporter1LinetheSubstrateBindingRegioninaModelDerivedfromtheTertiaryStructu
...nium(MPP)weredecreased.AfterreplacementofTrp218bytyrosine(W218Y)andTyr222byleucine(Y222L),theKmvaluesforbothTEAandMPPweredecreased.InmutantsY222FandT226A,onlytheKmvaluesforTEAandMPPweredecreased,respectively.ThedatasuggestthataminoacidsTrp218andTyr222participateinthebindingofbothTEAandMPP,whereasThr...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期Supplementationofsoyproteinwithbranched-chainaminoacidsaltersproteinmetabolisminhealthyelderlyandevenmoreinpatientswithchronicobstructive
...).PlasmaBCAAconcentrationswereoftenreducedinCOPD,mostlybecauseofadecreaseinleucine(Leu)(8).Furthermore,thelowplasmaLeuconcentrationswereassociatedwithlowvaluesforfat-freemass(6).ItisunknownwhetherBCAAadministrationinCOPDmaybeofbenefittoimproveproteinmetabolismandconsequentlypreventmusclewastinginthe...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第2期Ghrelinreceptormutations—toolittleheightandtoomuchhunger
...othephenotypeofsubjectscarryinganothernaturalghrelinreceptormutation,Phe279Leu,havingidenticalmolecular-pharmacologicalproperties,itisproposedthatselectivelackofghrelinreceptorconstitutivesignalingleadstoasyndromecharacterizednotonlybyshortstature,butalsobyobesitythatapparentlydevelopsduringpuberty....
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期結核分枝桿菌耐藥分子機制及檢測方法的研究進展
...27個氨基酸的81個鹼基範圍內[4]。其中,以531位Ser→Leu和Trp轉換,526位His→Tyr、Asp、Asn和Pro的突變最爲常見[5],且以上兩個位點的突變是引起高水平耐藥的主要原因。除上述兩位點外,511、516、518、522位點也有突變,相...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第3期IdentificationandCharacterizationofaNewTubulin-BindingTetrasubstitutedBrominatedPyrrole
...diesshowedthatJG-03-14hadpotentantiproliferativeeffectsagainstmouseandhumanleukemiacelllines(Guptonetal.,2000).JG-03-14InhibitstheGrowthofCancerCellLinesandEvadesP-Glycoprotein-MediatedDrugResistance.TheantiproliferativeeffectsofJG-03-14wereevaluatedinseveralcancercelllines,includingamultidrugresist...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第7期