DualSerotonergicRegulationofVentricularContractileForceThrough5-HT2Aand5-HT4ReceptorsInducedintheAcuteFailingHeart
...leftventriclehasbecomesensitivetoserotoninbecauseofappearanceofGs-coupled5-HT4receptors.WhetherthisalsooccursinacuteCHFisunknown.Serotoninresponsivenessmaydevelopgraduallyorrepresentanearlyresponsetotheinsult.Furthermore,serotoninreceptorexpressioncouldvarywithprogressionofthedisease.PostinfarctionC...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第8期MolecularDeterminantsfortheInteractionoftheValvulopathicAnorexigenNorfenfluraminewiththe5-HT2BReceptor
...e-threateningcardiovascularsideeffects.SNFreducesappetitethroughserotonin5-HT2Creceptoractivation;itcausescardiopulmonarysideeffectsthrough5-HT2Breceptoractivation.Thus,weattemptedtoidentifymoleculardeterminantsofSNFbindingto5-HT2BreceptorsdistinctfromthoseunderlyingSNF-5-HT2C/2Areceptorinteractions...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第1期PharmacologicalCharacterizationofSerotonergicReceptorActivityintheHypoglossalNucleus
...essedthedose–responsecurveforthe2Cagonist.Rapiddesensitizationoccurredwiththe2Cagonistonly(p0.05).The7antagonist,SB-269,970,hadnoeffectoneitherintrinsicactivityoragonistresponses.Weconcludethatserotonin2Aisthepredominantexcitatoryserotoninreceptorsubtypeathypoglossalmotorneurons.Theserotonin2Cexci...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2003年第167卷第4期RegionalDifferencesintheCouplingof5-Hydroxytryptamine-1AReceptorstoGProteinsintheRatBrain
...詞】5-Hydroxytryptamine-1ANumerousdatashowedthat5-hydroxytryptamine-1A(5-HT1A)receptorscoupletoGo/iproteinsforsignaltransduction.However,thesubunitisoformsreallyinvolvedin5-HT1Areceptorcouplinginbrainremaintobeidentified.Moreover,regionaldifferencesinthefunctionalcharacteristicsofbrain5-HT1Arecept...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期InverseAgonistandNeutralAntagonistActionsofAntidepressantsatRecombinantandNative5-Hydroxytryptamine2CReceptors:DifferentialModulationofCellS
【關鍵詞】InverseDespitetheimportanceof5-hydroxytryptamine(5-HT)2C(serotonin)receptorsinthecontrolofdepressivestates,actionsofantidepressantsatthesereceptorsremainpoorlycharacterized.Thisissuewasaddressedbothinhumanembryonickidney(HEK)-293cellscoexpressinguneditedhuman5-HT2CINIreceptorsandGqpro...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期ARoleforSerotonin(-HT)inHepaticStellateCellFunctionandLiverFibrosis
...icalandneurotrophicfactors.Thisstudyaddressesthepotentialfortheserotonin(5-HT)systemtoinfluenceHSCbiology.RatandhumanHSCsexpressthe5-HT1B,5-HT1F5-HT2A5-HT2B,and5-HT7receptors,withexpressionof5-HT1B5-HT2Aand5-HT2BbeinginducedonHSCactivation.Inductionof5-HT2Aand5-HT2Bwas106??39-and52??8.5-foldthatofqu...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第9期TheNaturalMutationEncodingaCTerminus-Truncated5-Hydroxytryptamine2BReceptorIsaGainofProliferativeFunctions
...ions,fewfunctionalmutationshavebeenidentifiedinthehuman5-hydroxytryptamine(HT)2Breceptorgene.AheterozygousmutationR393Xinthe5-HT2Breceptorwasrecentlyidentifiedinapatientdiagnosedwithpulmonaryhypertensionafterintakeoftheanorexigenicdexfenfluramine.Althoughreportedtogeneratealackoffunction,thisCtermin...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期笑氣用於分娩鎮痛臨牀分析
...症狀消失。3討論3.1產痛的普遍性和分娩鎮痛的必要性產痛是一個複雜的生理和心理過程,絕大多數的婦女認爲產痛是難以忍受的。有學者對35個國家121個產科中心,2700多產婦調查,不痛或輕微痛的佔15%,中等疼痛的佔30%,劇烈...
合作平臺;在線期刊;中華醫學研究雜誌;2005年第5卷第1期;預防醫學腹腔鏡手術治療慢性盆腔痛68例臨牀分析
...%)3.1腹腔鏡手術治療慢性頑固性盆腔痛療效佳慢性盆腔痛是婦科較爲常見病,特別是頑固性難治性病例,症狀反覆發作,久治不愈,給廣大患者造成了極大的身心痛苦,不僅影響了日常工作,生活質量,並造成了極大的經濟負...
合作平臺;在線期刊;中華中西醫雜誌;2004年第5卷第15期;臨牀醫學Serotonin5-Hydroxytryptamine2CReceptorSignalinginHypothalamicProopiomelanocortinNeurons:RoleinEnergyHomeostasisinFemales
...mitterreceptorsignalingpathwaysconvergetocontrolenergyhomeostasis.Because5-HT2CreceptorsmediatemanyoftheeffectsofserotonininPOMCneurons,weelucidatedthecommonsignalingpathwaysofE2and5-HTinguineapigsusingsingle-cellreversetranscription-polymerasechainreaction(RT-PCR),realtimeRT-PCR,andwhole-cellpatchr...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期