DefectiveBcelltolerancecheckpointsinsystemiclupuserythematosus
...ces28–38).Forexample,maturenaiveBcellsfromSLE122showedadecreaseinVH4(10.4vs.30.4%incontrols)andincreasedVH3(60.4vs.39.3%incontrols)genefamilyrepresentation(Fig.1B).SLE122wasalsounusualinthatIgHchainsfrombothnewemigrantandmaturenaiveBcellsdisplayedshortCDR3regions(Fig.1,AandB).Inthispatient,theaver...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...SR-BIinwild-typemice,comparedwithcontrols,reducedplasmalevelsofHDL-C(16±14vs.55±9mg/dl).Macrophage-derivedcholesterolinplasmaatboth24hoursand48hourswasalsosignificantlylowerinthemiceoverexpressinghepaticSR-BIcomparedwithcontrolmice(Figure1A).However,miceoverexpressinghepaticSR-BIhadsignificantlyhi...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期毛細管電泳-電化學檢測Vc銀翹片中的有效成分
...的靈敏度和檢測下限.Vc的響應電流在電極電位達到0.6V(vs.SCE)以後出現一個平臺;而綠原酸和咖啡酸的響應電流在0.6V(vs.SCE)以後快速上升,當電極電位超過+O.90V(vs.SCE)時,三者的響應電流上升緩慢,而噪音和基底電流大幅上...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Saturatedfat–richdietenhancesselectiveuptakeofLDLcholesterylestersinthearterialwall
...eriods,apoE–/–micehadhighercontributionofSUevenonachowdiet(C56BL/6,7.5%vs.apoE–/–,20.2%;P0.02).ThecontributionofSUincreasedsubstantiallywhenmicewereontheSATdietforlongertimeperiods.InapoE–/–micefedtheSATdietfor12weeks,SUcontributeduptoalmosthalfoftotalarterialLDL-CEuptake.Thissuggeststha...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期IdentificationofClinicallyRelevantViridansStreptococcibyanOligonucleotideArray
...ollegeofMedicine,Taipei,Taiwan,RepublicofChinaABSTRACTViridansstreptococci(VS)arecommonetiologicagentsofsubacuteinfectiveendocarditisandarecapableofcausingavarietyofpyogenicinfections.ManyspeciesofVSaredifficulttodifferentiatebyphenotypictraits.Anoligonucleotidearraybasedon16S-23SrRNAgeneintergenics...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期Complementactivationinducesdysregulationofangiogenicfactorsandcausesfetalrejectionandgrowthrestriction
...CBA/JxBALB/c:8.2±5.6%;DBA/2xDBA/2:8.5±6.6%;n=6–32mice/group;CBA/JxDBA/2vs.others,P0.01;Fig.1A).EmbryoniclethalityinDBA/2-matedfemaleCBA/Jmiceisbelievedtorepresentrejectionofthesemiallogeneicplacentabymaternal-derivedactivatedeffectors.Resorptionisnotuniversal,however,andsurvivingfetusesshowconsi...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第9期AcuteSustainedHypoxiaSuppressestheCoughReflexinHealthySubjects
...wassignificantlyhigherduringisocapnichypoxiacomparedwithnormoxia(29.6±16.0vs.23.4±15.6μM,p=0.01).Duringcontinuouscapsaicininhalation,significantlymorecoughswereevokedinthefirst10scomparedwiththelast(2.3±0.3vs.1.3±0.3,p0.01),indicatingcoughtachyphylaxis.However,thedecreasewasthesameduringhypoxia...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第5期TargetedinactivationofhepaticAbca1causesprofoundhypoalphalipoproteinemiaandkidneyhypercatabolismofapoA-I
...alcatabolicrate(FCR)comparedwithwild-typelittermaterecipientmice(2.88±0.14vs.1.68±0.61pools/day;P0.02),whereasheterozygousrecipientmicehadanintermediateFCR(2.00±0.12pools/day)(Figure5C).Productionrate,calculatedastheproductofplasmaapoA-IpoolsizeandplasmaFCR,was10-foldhigherinwild-typecomparedwith...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第5期Anti-A?42-andanti-A?40-specificmAbsattenuateamyloiddepositioninanAlzheimerdiseasemousemodel
...dFAA?42incontrolmicewere348±34and737±62pmol/g,respectively.*P0.05,**P0.01vs.control.Tofurtherexaminetherelativeefficacyoftheseanti-A?mAbsinalteringA?accumulation,wepassivelyimmunizedCRND8mice.ThistransgenicmodelhasaveryearlyonsetofA?deposition,bothasamyloidandinmorediffuseplaques.Furthermore,compa...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第1期廣州市天河區1162例患者高血脂檢出率回顧性分析
... 表2不同年齡組高血脂檢出率(略) 注:*老年前期vs中年:χ2=17.95,P<0.001。 2.3不同職業人羣高血脂症檢出率見表3。農民工、本地工人、幹部及其他人羣的高血脂症檢出率分別爲14.8%、25.3%、31.1%和14.6%,本地工人組高...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2007年第7卷第7期