PrincipalRoleofGlycoproteinVIin2?1andIIb?3ActivationDuringCollagen-InducedThrombusFormation
...romethylketone(PPACK)-anticoagulatedblood,asdescribed.22Briefly,wholebloodwasperfusedfor4minutesoveracollagen-coatedcoverslipthroughaparallel-platetransparentflowchamberatawall-shearrateof150to1000s–1.PSexposurewasdetectedbypostperfusionwithrinsingHepesbuffer,pH7.45(inmmol/L:136NaCl,10glucose,5Hep...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第9期第十六章 漿膜腔穿刺液及關節腔穿刺液檢查--第一節 漿膜腔穿刺液檢查
...白降解產物)、LD(乳酸脫氫酶)、ADA(腺苷脫氨酶)、ASP(酸溶性蛋白)、AMY(澱粉酶)、GP(糖蛋白)等。 (3)三級檢查:包括腫瘤標誌物CEA(癌胚抗原)、AFP(甲胎蛋白)、HDG(絨毛膜促性腺激素)、同工酶、蛋白質...
醫源資料庫;醫源圖書館;教材類;臨牀基礎檢驗學RadioprotectiveEffectofHeatShockProteinonSubmandibularGlandsofRats
...yamelioratedradiation-inducedsalivaryfluidloss.Radiation-inducedapoptosis,caspase-3activation,andpoly(ADP-ribose)polymerasecleavageinacinarcells,granularconvolutedcells,andintercalatedductalcellswerealsoinhibitedbyHSP25orHSP70itransfer.Thealterationofsalivarycontents,includingamylase,protein,Ca+,ClC...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第11期Chapter7-Instinct
...e.ButIcouldshowthatnoneofthesecharactersofinstinctareuniversal.Alittledose,asPierreHuberexpressesit,ofjudgmentorreason,oftencomesintoplay,eveninanimalsverylowinthescaleofnature.FrederickCuvierandseveraloftheoldermetaphysicianshavecomparedinstinctwithhabit.Thiscomparisongives,Ithink,aremarkablyaccura...
醫源資料庫;醫源圖書館;教材類;The Origin of SpeciesCaspase-MediatedCleavageofGlialFibrillaryAcidicProteinwithinDegeneratingAstrocytesoftheAlzheimer??sDiseaseBrain
【摘要】RecentstudiesdemonstraterolesforactivationofcaspasesandcleavageofcellularproteinswithinneuronsoftheAlzheimer??sdisease(AD)brain.TodeterminewhetherasimilarroleforcaspasesalsooccurswithinglialcellsinAD,wedesignedasite-directedcaspase-cleavageantibodyspecifictoglialfibrillaryacidicprotein(G...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第3期Asparaginase-InducedAntithrombinTypeIDeficiencyImplicationsforConformationalDiseases
...ptthestructurallysensitiveserpins,havenoknownacquiredcause.Interestingly,L-asparaginasetreatmentofacutelymphoblasticleukemiapatientscausesseveredeficiencyintheserpinantithrombin.Westudiedtheconsequencesofthisdrugonantithrombinlevels,activity,conformation,andimmunohistologicalandultrastructuralfeatur...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期微生物來源的具有促進纖溶作用的低分子化合物的研究進展
...)、酶活性中心結構域和C末端氨基酸。酶活性中心在His603-Asp645-Ser740,uPA或tPA限定分解Arg561-Val562肽鍵(圖中的虛心箭頭位置)成雙鏈的纖溶酶,PA(plasminogenactivator)切斷Arg561-Val562肽鍵後,N端的A鏈(或重鏈)C端的B鏈(或輕鏈)。...
醫源資料庫;在線期刊;中華醫學研究雜誌;2006年第6卷第12期急性胰腺炎相關性腹水與腎、肝、肺損傷關係
...ncreatitis,ANP)又稱爲急性重症胰腺炎(acuteseverpancreatitis,ASP),爲臨牀常見病,產生大量的胰腺炎相關性腹水(pancreatitis-associatedasciticfluids,PAAF),並有較高的胰外多器官損害率,也是急性壞死性胰腺炎主要的死亡原因。腹腔...
醫源資料庫;在線期刊;中華現代外科學雜誌;2006年第3卷第12期ComparativeModelsofGABAAReceptorExtracellularandTransmembraneDomains:ImportantInsightsinPharmacologyandFunction
...etal.,2002).ThestructureoftheionporedomainfragmentofthetorpedonAChreceptorwaspublishedin2003(Miyazawaetal.,2003)asa4-modelintherestingstate[ProteinDataBank(PDB)identifier1OED[PDB]].Italsohasbeenderivedfromcryo-EMimages,andconfirmedthenotionthatthetransmembranedomainofcys-loopreceptorsisorganizedasa4...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期Ironstatusofthefree-living,elderlyFraminghamHeartStudycohort:aniron-repletepopulationwithahighprevalenceofelevatedironstores
...decidedthatthestudyshouldbesetupinasingleareaandbelimitedto6000adultswithinaspecificagerangetoensureasufficientnumberofsubjectswhowerefreeofthediseaseofinterestatentry.TheindustrialandtradingtownofFramingham,MA,wasselectedbecause1)thepopulationof28000wasofsufficientsizetoensurethenecessarynumberofsu...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年73卷第3期