X染色體上首個腫瘤抑制基因-WTX
...力發育不全組成的一組少見性症候羣。這種腫瘤的發生與WT1腫瘤抑制基因的失活有關,這種基因編碼一種轉錄抑制因子,通過與啓動子的結合WT1可以抑制有關基因的轉錄,因此WT1被認爲是一種抑癌基因,其缺失或失活可能引發Wil...
行業資訊;臨牀快報;腫瘤相關AnIntracellularAllostericSiteforaSpecificClassofAntagonistsoftheCCChemokineGProtein-CoupledReceptorsCCR4andCCR5
...rch,2005).Muchoftheprogressindiscoveryofsmall-moleculeligands(i.e.,<500mol.wt.)forGPCRscomesfromimprovementsintechnologiestoscreenlargenumbersofcompounds,wheremanycampaignswillusefunctionalassayswithcelllinesgeneticallyengineeredtoexpresshighamountsoftheGPCRofinterest,oftencoexpressedwithageneticall...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期小鼠B7-1基因轉染的黑色素瘤細胞免疫原性探討
...色素瘤細胞(B16-mB7.1)與野生型及空載體轉染細胞(B16-wt和B16-neo)的免疫原性在體內外進行了比較。同源淋巴細胞腫瘤細胞混合培養(MTLCs)後測定淋巴細胞增殖指數和CTLs活性;將B16-neo和B16-mB7.1細胞接種於小鼠皮下,觀察腫瘤...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學AnInnerPoreResidue(Asn406)intheNav1.5ChannelControlsSlowInactivationandEnhancesMibefradilBlocktoT-TypeCa2+ChannelLevels
...dwith100µg/mlHygromycinBorHygroGold(Sigma,St.Louis,MO).Incomparisons,WTreferstoNav1.5orNav1.5C373Yasappropriateforthebackgroundinwhichthemutationsweremade;theseareindicatedinthefigurelegends.CellsweremaintainedinDulbecco‘smodifiedEagle‘smedium(Invitrogen)supplementedwith10%fetalbovineserum...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期Effectsofdairyproductsnaturallyenrichedwithcis-9,trans-11conjugatedlinoleicacidonthebloodlipidprofileinhealthymiddle-agedmen
...lmixedrationscontaining0(control)and45g/kg(ondrymatterbasis)ofamixture(1:2,wt:wt)offishoilandsunfloweroilduring2consecutive7-dperiodstoproducecontrolandCLA-enhancedmilks,respectively.Becausetheinclusionofoilsinthedietwasexpectedtoincreasetheunsaturatedfattyacidcontentofmilk,vitaminE(dl--tocopherylac...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年83卷第4期Glucose-6-PhosphateDehydrogenaseDeficiencyDecreasesVascularSuperoxideandAtheroscleroticLesionsinApolipoproteinE-/-Mice
...AmongmaleapoE-/-micethatwerefedawestern-typedietfor11weeks,G6PDwild-type(E-WT),andG6PDhemizygous(E-Hemi)micewerecompared.BasalbloodpressurewassignificantlyhigherinE-Hemi.However,superoxideanionrelease,nitrotyrosine,vascularcelladhesionmolecule(VCAM)-1,andinduciblenitricoxidesynthaseimmunohistochemic...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第4期DualPPAR/AgonistTesaglitazarReducesAtherosclerosisinInsulin-ResistantandHypercholesterolemicApoE3LeidenMice
...-resistance-inducingdiet.Onegroupreceivedahigh-cholesterol(HC)supplement(1%wt/wt;HCgroup).AsecondgroupreceivedthesameHCsupplementalongwithtesaglitazar(T)0.5µmol/kgdiet(Tgroup).Athird(control)groupreceivedalow-cholesterol(LC)supplement(0.1%wt/wt;LCgroup).Tesaglitazardecreasedplasmacholesterolby...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第11期HighAccumulationofPlatinum-DNAAdductsinStrialMarginalCellsoftheCochleaIsanEarlyEventinCisplatinbutNotCarboplatinOtotoxicity
...malcellsandtissues(e.g.,intheinnerearandthekidney)weremainlyascribeduntilnowtopathwaysnotprimarilytriggeredbydrug-mediatedDNAdamage.Mostinvestigationsattributedcisplatinototoxicityandnephrotoxicitytofreeradical-inducedcelldamage,whichismediatedbyreactiveoxygenspecies(ROS)(Husainetal.,2001;Minamietal...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期婆羅洲新發現奇異海蜘蛛須肢長滿刺
...發現和相關研究成果,科考發現中包括四種新的奇異無尾海蜘蛛物種。1.無尾海蜘蛛無尾海蜘蛛(圖片提供:CahyoRahmadi)這隻海蜘蛛正在印尼的一個洞穴中飽餐一隻蟋蟀。這種海蜘蛛是本月公佈的新發現的四種海蜘蛛新物種之一,...
醫藥經濟;生物技術;技術要聞海蝸牛爲何能進行光合作用詳解PNAS論文
...美國科研人員日前捕捉到一種極不尋常的生物——一種以海藻爲食並將海藻色素吸收到自身細胞中的海蝸牛。更令人驚訝的是,這種蝸牛不僅能借此進行很好的僞裝,還能像植物一樣進行光合作用以獲取能量。”(見更多閱讀)...
醫藥經濟;生物技術;技術要聞