Afunctionalpromoterpolymorphisminmonocytechemoattractantprotein–1isassociatedwithincreasedsusceptibilitytopulmonarytuberculosis
...nucleotidepolymorphism.P.O.Flores-VillanuevaandJ.A.Ruiz-Moralescontributedequallytothiswork.Studiesofmonozygoticanddizygotictwinshavedemonstratedthatgeneticfactorscontributeconsiderablytothedevelopmentoftuberculosis(1,2).The17q11.2chromosomalregionhasbeenlinkedtosusceptibilitytotuberculosis(3,4)andi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第12期RegulationofLymphocyteApoptosisbyInterferonRegulatoryFactor4(IRF-4)
...ofFasandinthetransmissionofastrongdeathsignal(4).Transductionofthissignalrequirestheassemblyofadeath-inducingsignalingcomplex(DISC),whichinvolvestherecruitmentoftheFas-associateddeathdomain(FADD)adaptorproteinandofcaspase-8,acriticalinitiatorcaspasetothecytoplasmicportionoftheFasreceptor(5).Interact...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期牛磺酸對大鼠慶大黴素中毒性急性腎損傷的保護作用
...級。0級:腎組織結構無異常;1級:腎小管上皮細胞局竈性顆粒空泡變性,小管腔有顆粒狀碎屑,有或無小竈狀上皮脫落(<1%腎小管出現上皮脫落);2級:50%的近端小管出現上皮壞死及脫落,但易見到完好的腎小管;4級:完全或幾...
醫源資料庫;在線期刊;齊魯醫學雜誌;2007年第22卷第5期CataractsurgicalcoverageandbarrierstouptakeofcataractsurgeryinleprosyvillagesofnortheasternNigeria
...sandaboveresidentineightleprosyvillageswereexamined.Cataractblindpeoplewerequestionedaboutthereasonstheyhadnotbeentreated.Subjectswhohadreceivedanoperationforcataractwereexaminedtodeterminetheoutcomeand,whereapplicable,thecausesofpooroutcome.Results:480peoplewereexamined.Cataractwasthecommonestcause...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第8期HSP70對缺血預處理誘導大鼠海馬缺血耐受的作用
...區染色增強,尤以CA3區及齒狀回區染色爲深,可見棕黃色顆粒位於神經元的胞體及軸突的胞漿內;C、D組CA1區均未見明顯着色;E、F組海馬各區均可見HSP70染色,在整個海馬區均可見HSP70的棕黃色顆粒,尤以CA1區及CA3區錐體細胞、...
醫源資料庫;在線期刊;齊魯醫學雜誌;2008年第23卷第2期頭孢丙烯片工藝研究
...處方,將主藥和輔料混合均勻後投入乾式制粒機滾壓制幹顆粒(控制設備運行參數),用20目篩整粒,收率約86%,整粒後餘下細粉再投入乾式制粒機中重複操作,收率約79%,將所得幹顆粒合併,兩次制粒總收率約97%,以幹顆粒壓...
合作平臺;在線期刊;中華實用醫藥雜誌;2005年第5卷第7期;藥物臨牀低劑量輻射對小鼠S180肉瘤組織EPO和VEGF表達影響
....3結果判定EPO主要表達於腫瘤細胞的胞漿,以細胞漿呈棕色顆粒狀染色爲陽性表達。VEGF主要表達於細胞漿,以細胞漿顯示棕黃色顆粒爲陽性表達。每隻動物隨機選取5張切片,顯微鏡下每張切片隨機觀察10個高倍視野(400倍),每個...
醫源資料庫;在線期刊;齊魯醫學雜誌;2009年第24卷第4期Noaudiblewheezing:nuggetsandconundrumsfrommouseasthmamodels
...Tlymphocytes(6).EffectorTlymphocytesarenecessaryandsufficienttoprovidetherequisiteTh2cytokinesthatinducebothhistologicchangesandinducedAHR.Theuseofknock-outmiceand/orblockadewithspecificantibodiesinwild-typemicerevealedthatIL-4signalingthroughtheIL-4receptorsubunit(IL-4R),andsubsequentSTAT6-dependen...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期GeneticDiversityandRecombinationofPorcineSapoviruses
...egeneticdiversityofporcineSaVsandtheirgeneticrelatednesstohumanstrains,wesequenced286nucleotides(nt)oftheRNA-dependentRNApolymerase(RdRp)regionofnineporcineSaVsdetectedfromfieldpigfecalsamplescollectedinU.S.swinefarmsduringtheperiodfrom1999to2003.Onestrain(Po/SaV/MI-QW19/2002/US)wasmostcloselyrelate...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期PhenylglycineandSulfonamideCorrectorsofDefectiveF508andG551DCysticFibrosisTransmembraneConductanceRegulatorChloride-ChannelGating
...essingF508-CFTRandafluorescenthalideindicator(yellowfluorescentprotein-H148Q/I152L)afterF508-CFTRrescueby24-hcultureat27°C.Secondaryanalysisandtestingof1000structuralanalogsyieldedtwonovelclassesofcorrectorsofdefectiveF508-CFTRgating(“potentiators“)withnanomolarpotencythatwereactiveinhumanF508a...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期