CAR-NK,抗腫瘤免疫療法的研究新技術
...逸機制更加多樣,靶點更加繁雜,研究者們更加希望CAR-NK能夠在實體瘤中突破研究的瓶頸,完成CAR-T未能完成的任務。CAR技術的前進依賴着深入的腫瘤發生、發展機制研究和強大的基因編輯技術,研究者們正在多個方面進一步探...
醫藥經濟;生物技術;技術要聞HumanApolipoproteinA-IVReducesSecretionofProinflammatoryCytokinesandAtheroscleroticEffectsofaChronicInfectionMimickedbyLipopolysaccharide
...tributionofthelymphocytesubsetsinperipheralbloodmononuclearcells(PBMC):CD3/NK1.1/IL-4,CD3/CD4/IFN-,andCD3/CD8/TNF-.TheLPSgroupofh-apoA-IV/E0miceproducedlesscytokinesthantheLPS-injectedapoE0andwild-typemice(Figure2).LPS-injectedh-apoA-IV/E0micecontainedalowerproportionoftheIL-4–producingcellsthanth...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期AtheroscleroticAbdominalAorticAneurysmandtheInteractionBetweenAutologousHumanPlaque-DerivedVascularSmoothMuscleCells,Type1NKT,andHelperTC
...nvitro.WeshowherethatapartfromTlymphocytes,plaqueinfiltratesconsistoflotsofNKcellsandsignificantproportionsofNKTcellsthatexpressTcellreceptor(TCR),CD4,andtheNKmarkersCD56andCD161.TheinfiltratesarepredominantlyIFN-eCproducingType1lymphoidcells.Whencocultured,theTandNKTcellsadheretoVSMCs.CD4+Tcellsenh...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期LineagespecificationandplasticityinCD19–earlyBcellprecursors
...eportertransgenicmice(17),lineage-negativegating(10,24),andseparationbasedonkeycellsurfacemarkerssuchasLy6c(15),CD117/cKit,andCD127/IL-7R(10).Usingthistypeofanalysis,wecaneasilycorrelateourresultswithanalysesdonebyothers(10,15–17,25).ThegoalofourworkistoconnecttheB220–CLPstage(10)totheCD19+pro...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期二、NK細胞的表型
二、NK細胞的表型 與T細胞、B細胞相比,NK細胞表面標誌的特異性是相對的。人NK細胞mIg-,部分NK細胞CD2、CD3和CD8陽性,表達IL-2受體β鏈(P75,CD122),CD11b/CD18陽性。目前常用檢測NK細胞的標記有CD16、CD56、CD57、CD59、CD11b、CD94...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學用噬菌體抗體庫分離NK細胞抑制受體特異性的ScFv片段
...edisplay DNA,Single-stranded 自然殺傷(naturalkiller,NK)細胞能夠裂解表面失去或低表達MHCⅠ類分子的細胞。近年來發現,其識別過程是由NK細胞表面的Ⅰ類分子性殺傷細胞抑制受體(killercellinhibitoryreceptors,KIRs)介導的〔1〕。NK細胞克...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學ASSENT-4PCI研究
...SocietyofCardiologyHotLineSession2005PresentedbyDr.FransVandeWerfFull-doseTNK+PrimaryPCI60IU/kg,maximum4000IUn=829GPIIb/IIIainhibitorsallowedonlyforbailoutuseASSENT-4PCITrial1667patientsage18yearswithSTelevationmyocardialinfarction(summedSTdeviation6mm);timefromsymptomonsetwithin6hrs;intenttoperform...
醫源資料庫;醫學文檔庫;心血管相關AcrucialroleforplasmacytoiddendriticcellsinantiviralprotectionbyCpGODN–basedvaginalmicrobicide
...arietyofinflammatorycellshavebeenshowntoaccumulateinvaginalmucosa,includingNKcells,CD11b+F4/80+myeloidcells,andCD11b+CD11c+DCs(5,8).ThereareconflictingobservationsregardingtherolesofTcellsandIFN-.ApreviousstudyhasshownthattheprotectionrequiresIFN-,IL-12,IL-18,andTcells(6)whileothershavedemonstratedt...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第8期IndependentrolesforIL-2andGATA-3instimulatingnaiveCD4+TcellstogenerateaTh2-inducingcytokineenvironment
...lester;ERK,extracellularsignal-regulatedkinase;MAPK,mitogen-activatedproteinkinasekinase;MEK,mitogen-activatedproteinkinase;JNK,c-JunN-terminalkinase;PFA,paraformaldehyde;pPCC,pigeoncytochromecpeptide.NaiveCD4+Tcellscandifferentiateintoatleasttwomajordistinctphenotypes,Th1andTh2cells,whicharecharact...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第6期Howearlydietaryfactorsmodifytheeffectofrapidweightgainininfancyonsubsequentbody-compositiondevelopmentintermchildrenwhosebirthweightwas
NadinaKaraolis-Danckert,AnkeLBGünther,AnjaKroke,ClaudiaHornbergandAnetteEBuyken1FromtheResearchInstituteofChildNutrition,RheinischeFriedrich-Wilhelms-UniversitätBonn,Dortmund,Germany(NK-D,ALBG,andAEB);theDepartmentofNutrition,FoodandConsumerSciences,FuldaUniversityofAppliedSciences,Fulda,G...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第6期