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EvaluationofReal-TimeReverseTranscriptasePCRandReal-TimeLoop-MediatedAmplificationAssaysforSevereAcuteRespiratorySyndromeCoronavirusDetection
...enMaryHospitalDivisionofInfectiousDiseases,CentreofInfection,UniversityofHongKong,HongKong,SpecialAdministrativeRegion,People‘sRepublicofChinaABSTRACTWecomparedtheperformanceofarecentlyestablishedreal-timeloop-mediatedamplification(LAMP)assaywiththeonefromahighlysensitivequantitativePCRassay.Noneo...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第7期 -
ImpaireddegranulationbutenhancedcytokineproductionafterFcRIstimulationofdiacylglycerolkinase–deficientmastcells
...yMedicalCenter,Durham,NC27710Calciumanddiacylglycerolarecriticalsecondmessengersthattogethereffectmastcelldegranulationafterallergencross-linkingofimmunoglobulin(Ig)E-boundFcRI.Diacylglycerolkinase(DGK)isanegativeregulatorofdiacylglycerol-dependentsignalingthatactsbyconvertingdiacylglyceroltophospha...
醫源資料庫；在線期刊；實驗醫學雜誌；2006年第203卷第6期 -
CD4+CD25+regulatoryTcellsinhibitnaturalkillercellfunctionsinatransforminggrowthfactor––dependentmanner
...France7HospicesCivilsdeLyon,HpitalEdouardHériot,69003Lyon,France8CentreJeanGodineau,EtablissementFranaisduSang,51056Reims,France9INSERM,U561,HpitalSaintVincentdePaul,AssistancePublique-HpitauxdeParis,75674Paris,France10UnitéBiologiedesPopulationsLymphocytaires,CentreNationaldelaRechercheScientifiq...
醫源資料庫；在線期刊；實驗醫學雜誌；2005年第202卷第8期 -
EndocannabinoidactivationathepaticCB1receptorsstimulatesfattyacidsynthesisandcontributestodiet-inducedobesity
...da,Maryland,USA.2DepartmentsofPhysiologyandAnesthesiology,UniversityofWashington,Seattle,Washington,USA.AbstractEndogenouscannabinoidsactingatCB1receptorsstimulateappetite,andCB1antagonistsshowpromiseinthetreatmentofobesity.CB1–/–miceareresistanttodiet-inducedobesityeventhoughtheircaloricintakei...
醫源資料庫；在線期刊；臨牀研究雜誌；2005年第115卷第5期 -
HydrogenPeroxide–ScavengingPropertiesofNormalHumanAirwaySecretions
...llavageswereobtainedfromeightpatientsintubatedforelectivesurgeryandfreeoflungdisease.Thesesamples(20µl,approximately6.8µgofprotein)scavenged0.57±0.09nmolofadded0.96nmolhydrogenperoxide(H2O2)within10minutesatroomtemperature(n=8).Thescavengingactivitywasinhibited60±4%byazide(aninhibitoro...
醫源資料庫；在線期刊；美國呼吸和危急護理醫學；2003年第167卷第3期 -
RapidandSensitiveDetectionofSevereAcuteRespiratorySyndromeCoronavirusbyRollingCircleAmplification
...TechnologyCIDMLS,ICPMR,WestmeadHospital,Sydney,NewSouthWales,AustraliaBeijingJDKBio-technologyInstitute,NationalInstituteofVirology,ChineseAcademyofPreventiveMedicine,Beijing,ChinaABSTRACTThesevereacuterespiratorysyndrome(SARS)epidemicof2003wasresponsiblefor774deathsandcausedsignificanteconomicdamag...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第5期 -
Postnatalacquisitionofendotoxintoleranceinintestinalepithelialcells
....Here,weusedhighlyenrichedprimaryIECstoanalyzeToll-likereceptor(TLR)signalingandmechanismsthatpreventinappropriatestimulationbythecolonizingmicroflora.Althoughthelipopolysaccharide(LPS)receptorcomplexTLR4/MD-2waspresentinfetal,neonatal,andadultIECs,LPS-inducednuclearfactorB(NF-B)activationandchemoki...
醫源資料庫；在線期刊；實驗醫學雜誌；2006年第203卷第4期 -
PhosducinandPhosducin-likeProteinAttenuateG-Protein-CoupledReceptor-MediatedInhibitionofVoltage-GatedCalciumChannelsinRatSympatheticNeurons
...(PDCL)isthesequestrationof“free“Gfromtheplasmamembrane,therebyterminatingsignalingbyG.ThefunctionalimpactofheterologouslyexpressedPDCandPDCLonN-typecalciumchannel(CaV2.2)modulationwasexaminedinsympatheticneurons,isolatedfromratsuperiorcervicalganglia,usingwhole-cellvoltageclamp.ExpressionofPDCan...
醫源資料庫；在線期刊；分子藥理學雜誌；2006年第68卷第7期 -
ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...IL-2secretion.TheYMNMmotifthatexistsintheCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailst...
醫源資料庫；在線期刊；美國病理學雜誌；2003年第162卷第2期 -
ASingleAminoAcidAlterationinCytoplasmicDomainDeterminesIL-2PromoterActivationbyLigationofCD28butNotInducibleCostimulator(ICOS)
...IL-2secretion.TheYMNMmotifthatexistsintheCD28cytoplasmicdomainisaknownbindingsiteforphosphatidylinositol3-kinase(PI3-K)andGrb2.ICOSpossessestheYMFMmotifinthecorrespondingregionofCD28thatbindsPI3-KbutnotGrb2.WepostulatedthatthereasonthatICOSdoesnothavetheabilitytoinduceIL-2productionisbecauseitfailst...
醫源資料庫；在線期刊；實驗醫學雜誌；2003年第197卷第2期