LaminarShearStressInhibitsCathepsinLActivityinEndothelialCells
...icro;mol/LCA074),L(1µmol/LZ-FY(t-Bu)-DMK),K(1µmol/L1,3-Bis(CBZ-Leu-NH)-2-propanone,Calbiochem),orS(1nMµ-Leu-Hph-VS-Ph).22Gelswerethenrinsedwithdeionizedwater,stainedwithCoomassieBlueanddestained,andanalyzedbydensitometry.CysteineProteaseActiveSiteLabelingConditionedmediawerenormali...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期InductionofvascularleakagethroughreleaseofbradykininandanovelkininbycysteineproteinasesfromStaphylococcusaureus
...BKB2-receptor–dependenthypotension.ScpAandSspBtogetherinducedthereleaseofleucyl-methionyl-lysyl-BK,anovelkininwithVLandbloodpressure–loweringactivitiesthatareequivalenttoBK.Collectively,thesedatasuggestthatproductionofBKandleucyl-methionyl-lysyl-BKbystaphopainsisanewmechanismofS.aureusvirulencea...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第10期幹化學法尿液檢測假陽性的探討
...(其可測項目爲:BIL、UBG、KET、ASC、GLU、PRO、BLD、pH、NIT、LEU、SG)及其配套使用的進口UrˉinChek10+SG尿十一項試劑帶,日本生產的OLYMPUS顯微鏡。 1.3檢測方法(1)嚴格按儀器操作規程進行測定。(2)手工法按《全國臨牀檢驗操...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第8A期APotentialRoleforCyclizedQuinonesDerivedfromDopamine,DOPA,and3,4-DihydroxyphenylaceticAcidinProteasomalInhibition
...nase-mediatedgenerationofdopamineo-quinoneandatphysiologicalpHcyclizationtoleukoaminochrome,subsequentoxidationtothecyclizedo-quinoneaminochrome(Scheme1)witheventualpolymerizationtomelanins(Graham,1978;Grahametal.,1978).Therehasbeensomedebateregardingtheexpressionoftyrosinaseinthesubstantianigra(Xue...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期淋巴結外小腸間變性大細胞淋巴瘤1例病理報告
...8、Mac387標記與惡性組織細胞增生症鑑別;用CD15、LCA、EMA、Leu-M1標記與霍奇金病鑑別(霍奇金病CD15、Leu-M1陽性,而LCA、EMA陰性);用細胞角蛋白、Lu-5與低分化癌鑑別;用HMB45、S-100可與惡性黑色素瘤鑑別。參考文獻1季天海,姚麗青,...
合作平臺;在線期刊;中華醫學實踐雜誌;2004年第3卷第8期;病例報告寧夏漢族人羣細胞色素P4501B1SNPrs1056836分佈研究
...即外顯子2上的Arg48Gly、Ala119Ser和外顯子3上的1294位C→G(Leu432Val)即rs1056836、1358A→G(Asn453Ser),其等位基因頻率具有種族差異[4,5]。外顯子3上有三個多態位點導致了氨基酸的改變,而453A→G和443C→G比較少見,故432C→G(CY...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第10期Real-TimeAnalysisofAgonist-InducedActivationofProtease-ActivatedReceptor1/Gi1ProteinComplexMeasuredbyBioluminescenceResonanceEnergyTransferin
...lyclonalrabbitanti-Gi1/2antibody(Lledoetal.,1992)andTRAP-14peptide(Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe-NH2)weregenerousgiftsfromDr.V.Homburger(IGF,Montpellier,France);SCH79797,Thr-Phe-Leu-Leu-Arg-NH2(TFLLR),andSer-Leu-Iso-Gly-Arg-Leu-NH2(SLIGRL)peptideswerefromTocrisCooksonInc.(E...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第5期HelixIof-ArrestinIsInvolvedinPostendocyticTraffickingbutIsNotRequiredforMembraneTranslocation,ReceptorBinding,andInternalization
...athicandpotentiallyamphitropic(membrane-targeting),withhydrophobicresidues(Leu100,Leu104,andLeu108,arr1numbering)alignedononesideofthehelixandpositivecharges(Arg99,Arg103,Lys106,andLys107)alignedontheoppositeside(Hanetal.,2001).Thissuggestsapossibleroleinmembranetargetingandfacilitationofreceptorint...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第2期ResiduesMet89andSer160intheHumanEquilibrativeNucleosideTransporter1AffectItsAffinityforAdenosine,Guanosine,S6-(4-Nitrobenzyl)-mercaptopurine
...ibitionbyNBMPRof[3H]adenosinetransportbywild-type(WT),single,ordouble(e.g.,Leu/Asp)mutanthENT1-expressingyeast.TheIC50values(mean±S.D.;n=3)ofdipyridamoleanddilazepwereestimatedbynonlinearregressionanalysisoftheinhibitionof[3H]adenosinetransportbyhENT1wild-type(WT),single,orMet89Cys/Ser160Cys(cystei...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期Subtype-SpecificAffinityforCorticosteroneofRatOrganicCationTransportersrOCT1andrOCT2DependsonThreeAminoAcidswithintheSubstrateBindingRegi
...noacidsinrOCT2decreasedtheaffinityforcorticosterone.Theseaminoacids(Ala443,Leu447,andGln448inrOCT1andIle443,Tyr447,andGlu448inrOCT2)areprobablylocatedwithinthesubstratebindingregionbecauseinrOCT1mutants,theKmvaluesforuptakeoftetraethylammonium(TEA)and1-methyl-4-phenylpyridinium(MPP)weredecreasedinpa...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期