IL-13R130Q,acommonvariantassociatedwithallergyandasthma,enhanceseffectormechanismsessentialforhumanallergicinflammation
1FunctionalGenomicsLaboratory,2ArizonaRespiratoryCenter,and3DepartmentofCellBiology,CollegeofMedicine,UniversityofArizona,Tucson,Arizona,USA.AbstractGeneticfactorsareknowntostronglyinfluencesusceptibilitytoallergicinflammation.TheTh2cytokineIL-13isacentralmediatorofallergyandasthma,andcommonsingle-n...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期EssentialroleoftheTcell–specificadapterproteinintheactivationofLCKinperipheralTcells
...ctivationofPLC1andtheRaspathway.Immunity.9:617–626.Zhang,W.,R.P.Trible,M.Zhu,S.K.Liu,C.J.McGlade,andL.E.Samelson.2000.AssociationofGrb2,Gads,andphospholipaseC-1withphosphorylatedLATtyrosineresidues.EffectofLATtyrosinemutationsonTcellangigenreceptor-mediatedsignaling.J.Biol.Chem.275:23355–23361.M...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期UseofVariable-NumberTandemRepeatsToExamineGeneticDiversityofNeisseriameningitidis
DivisionofInfectiousDiseaseControl,NorwegianInstituteofPublicHealthInstituteofOralBiology,DentalFaculty,UniversityofOslo,Oslo,NorwayABSTRACTRepetitiveDNAmotifswithpotentialvariable-numbertandemrepeats(VNTR)wereidentifiedinthegenomeofNeisseriameningitidisandusedtodevelopatypingmethod.Atotalof146menin...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期CD36maydetermineourdesirefordietaryfats
DepartmentofMedicine,DivisionofNutritionalScience,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,USA.AbstractThereisastronglinkbetweenhighfatintakeandobesity.Inadditiontoitshighcaloricdensity,dietaryfathasahyperphagiceffect,inpartasaresultofitshighpalatability.TherecentidentificationbyLauger...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期Bcl-2–relatedproteinA1isanendogenousandcytokine-stimulatedmediatorofcytoprotectioninhyperoxicacutelunginjury
1DepartmentofInternalMedicine,SectionofPulmonaryandCriticalCareMedicine,YaleUniversitySchoolofMedicine,NewHaven,Connecticut,USA.2PulmonaryandCriticalCareUnit,MassachusettsGeneralHospital,HarvardMedicalSchool,Boston,Massachusetts,USA.3DepartmentofPediatrics,OregonHealthSciencesUniversity,Portland,Ore...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期Organiccationtransporter3modulatesmurinebasophilfunctionsbycontrollingintracellularhistaminelevels
...gydiagnosis.Int.Arch.AllergyImmunol.133:317–329.Min,B.,M.Prout,J.Hu-Li,J.Zhu,D.Jankovic,E.S.Morgan,J.F.UrbanJr.,A.M.Dvorak,F.D.Finkelman,G.LeGros,andW.E.Paul.2004.BasophilsproduceIL-4andaccumulateintissuesafterinfectionwithaTh2-inducingparasite.J.Exp.Med.200:507–517.Schneider,E.,H.Pollard,F.Lepa...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第3期HPLC測定血漿中福辛普利的活性代謝物福辛普利拉濃度
...建立人血漿中福辛普利拉HPLC測定法,爲血藥濃度監測和臨牀合理用藥提供方法學基礎。方法:血漿樣品酸化後用乙醚-二氯甲烷混合溶媒提取,以雙氯芬酸鈉爲內標,流動相爲甲醇-10mmol·L-1磷酸氫二鉀溶液(內含5mmol·L-1氯化四丁...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例Inhypertension,thekidneyisnotalwaystheheartofthematter
MolecularCardiologyResearchInstitute,Tufts–NewEnglandMedicalCenter,Boston,Massachusetts,USA.AbstractBloodpressureabnormalitiesarethoughttooriginatefromintrinsicchangesinthekidney,aconceptthathasbeenlargelyunchallengedformorethan4decades.However,recentmolecular,cellular,andtransgenicmousestudiessup...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期HPLC測定血漿中福辛普利的活性代謝物福辛普利拉濃度
...建立人血漿中福辛普利拉HPLC測定法,爲血藥濃度監測和臨牀合理用藥提供方法學基礎。方法:血漿樣品酸化後用乙醚-二氯甲烷混合溶媒提取,以雙氯芬酸鈉爲內標,流動相爲甲醇-10mmol·L-1磷酸氫二鉀溶液(內含5mmol·L-1氯化四丁...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Gadd45andGadd45arecriticalforregulatingautoimmunity
...tedandrestingprimarymacrophagesbyIL-10.J.Immunol.169:2253–2263.Yang,J.,H.Zhu,T.L.Murphy,W.Ouyang,andK.M.Murphy.2001.IL-18-stimulatedGADD45requiredincytokine-induced,butnotTCR-induced,IFN-production.Nat.Immunol.2:157–164.Lu,B.,A.F.Ferrandino,andR.A.Flavell.2004.Gadd45isimportantforperpetuatingcog...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期