Low-DensityLipoproteinFromApolipoproteinE-DeficientMiceInducesMacrophageLipidAccumulationinaCD36andScavengerReceptorClassA-DependentManner
...5and6,J774cells.Concentration-dependentcellassociation(B)ordegradation(C)of125I-E–/–LDLand125I-Lr–/–LDLat37°Cfor2hourswasquantifiedasdescribedinMethods.ShownareCD36-specificvalues,whichwerecalculatedasthedifferencebetweenAdCD36-treatedcellsandAdNull-treatedcells.ApparentassociationKdvaluesf...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第1期SeminationalSurveillanceofFungemiainDenmark:NotablyHighRatesofFungemiaandNumbersofIsolateswithReducedAzoleSusceptibility
...lesusceptibility,definedasafluconazoleMICof8μg/mland/oritraconazoleMICof0.125μg/ml,wasdetectedfor11CandidaisolatesthatwereneitherC.glabratanorC.krusei.Includingintrinsicallyresistantfungi,wedetecteddecreasedsusceptibilitytofluconazoleand/oritraconazolein87(32%)currentDanishbloodstreamfungalisolate...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期Neurokinin-3Receptor-SpecificAntagonistsTalnetantandOsanetantShowDistinctModeofActioninCellularCa2+MobilizationbutDisplaySimilarBindingKine
...calslopewhen[MePhe7]neurokininB(NKB)wasusedastheothercompetitionpartnerwith125I-[MePhe7]NKBastheradioligand,indicatingcompetitivebindingofeitherantagonistwithregardto[MePhe7]NKB.Similarpatternswereobtainedwhentalnetantwastestedagainstosanetant,indicatingcompetitivebindingbetweenthetwoantagonistsaswe...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期AntioxidantsInhibittheAbilityofLysophosphatidylcholinetoRegulateProteoglycanSynthesis
...n.First,quiescentSMCsweretreatedwithincreasingconcentrations(0to0.4mg/mL)of125I-catalasefor24hours,afterwhichcellswerewashedwithPBS,treatedwithtrypsintoremovesurface-associated125I-catalase,washedagainwithPBS,andsonicatedin50mmol/Lpotassiumphosphatewith0.1%TritonX-100atpH7.8.Cellular125I-catalaseupt...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第3期Outcomesofreferralsbycommunityoptometriststoahospitalglaucomaservice
...OP).Adiagnosisofocularhypertensionwasmadein747patients(29.8%ofreferrals)and125(5.0%)werecategorisedasglaucomasuspects.Therewasnoevidenceofadiagnostictrendovertheperiodofdatacollection.TreatmenttolowerIOPwascommencedin458patients(18.3%).Nearlyhalfofthosereferred,1148(45.8%),weredischargedfromophthalm...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第9期NovelPotentHumanEther-e?Go-Go-RelatedGene(hERG)PotassiumChannelEnhancersandTheirinVitroAntiarrhythmicActivity
...and20mMCsCl,pHadjustedto7.4withCsOH.Theinternalpipettesolutionwascomposedof125mMCsCl,5mMMgATP,10mMHEPES,15mMEGTA,and20mMTEA-Cl,pHadjustedto7.2withCsOH.ForIK1andIKsrecordings,bathsolutioncontained137mMNaCl,5.4mMKCl,1.8mMCaCl2,1mMMgCl2,10mMHEPES,0.33mMNaH2PO4,and10mMglucose,pHadjustedto7.4withNaOH.CdC...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第3期RoleofAdenosineandNitricOxideontheMechanismsofActionofDipyridamole
...)wasmeasuredbyvenousocclusionplethysmography.Results—Adenosineatadosageof125μg/minincreasedFBFfrom4.6±0.9to29.4±5.3(539%increase)withdipyridamole/aspirinandfrom3.9±0.8to12±2.5mL/100mLforearm/min(208%increase)withaspirinalone(P=0.007).Incontrast,dipyridamole/aspirindidnotaltertheresponsetoacet...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第10期AdipophilinEnhancesLipidAccumulationandPreventsLipidEffluxFromTHP-1Macrophages
...d83%acetylatedlysineresidues.CellAssociation,Degradation,andBindingofIodine125–AcLDLAcLDLwerelabeledwith125I,usingthemethodreportedearlier.22Thespecificactivityof125I–AcLDLwas429cpm/ng.Lipoproteinuptakeanddegradationweredeterminedafterincubationofthecellswith125I–AcLDLat37°Cfor4hoursandlipopr...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第3期Longitudinalexaminationof24-hurinaryiodineexcretioninschoolchildrenasasensitive,hydrationstatusindependentresearchtoolforstudyingiodin
...of83µgI/Lin1996to148µgI/Lin1999,whichwasthenfollowedbyadecreaseto125µgI/Lin2003(12).Tospecificallyexaminethelong-termtrendsinISfrom1996to1999andfrom2000to2003,westudiedthe24-hurinaryiodineexcretion(24-hUI)inasampleofGermanschoolchildrenwhowerefollowedlongitudinallyovertherespective8-y...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年83卷第3期GrowthHormoneInducesLow-DensityLipoproteinClearancebutnotBileAcidSynthesisinHumans
...withdifferentLDLRexpression.MethodsandResults—Plasmaclearanceofautologous125I-LDLwasmeasuredbeforeandduring3weeksoftreatmentwithGH(0.1IU/kgperday)in9healthyyoungmales.PlasmaLDLcholesterolwasreducedby13%andthefractionalcatabolicrateofLDLincreasedby27%.Moremarkedchangeswereseeninapatientwithhypopitu...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第2期