CD44分子生物學特性及腫瘤關係的研究進展
...Aa。 CD44S的胞外近膜區存在一個56Aa的結構域(161Arg-216Asp),含有19個ser和Thr殘基,常以2~4個成簇,這些是已知的O-糖基化位點特徵,表明CD44有7個潛在的O-糖基化位點,其中4~5個位點被利用。此外這一區域含有4個Ser-Gly二肽...
合作平臺;醫學論文;基礎醫學論文;生理學CholinedeficiencyincreaseslymphocyteapoptosisandDNAdamageinhumans
...ymphocyteswereisolated.DNAdamageandapoptosiswerethenassessedbyactivationofcaspase-3,terminaldeoxynucleotidetransferasemediateddUTPnickend-labeling,andsingle-cellgelelectrophoresis(COMET)assays.Results:Allsubjectsfedthecholine-deficientdiethadlymphocyteDNAdamage,asassessedbyCOMETassay,twicethat...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第1期EffectofCOXinhibitorsandNOonrenalhemodynamicsfollowingischemia-reperfusioninjuryinnormotensiveandhypertensiverats
...spontaneouslyhypertensiverats(SHRSP)weredosedwithpolyethyleneglycolvehicle,aspirin(53.5mg・kg1・day1),NO-aspirin(100mg・kg1・day1),orcelecoxib(10mg・kg1・day1)for7days.Onday7,ratswereanesthetizedwithchloralose/urethaneandtheleftkidneywasexposedtoa30-minperiodofischemiafollowedby90-minreperfusi...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第11期治療血栓性疾病藥物的研究進展
...酵。我國生產的重組水蛭素屬HV-2序列,但經改造,第47位Asp換成Lys,且重組水蛭素中沒有硫酸酯,不僅比活大大提高,而且較水蛭素的出血不良反應發生率低,重組水蛭素是迄今發現的最強的凝血酶的抑制劑,因而臨牀應用較廣...
醫源資料庫;在線期刊;中華中西醫雜誌;2006年第7卷第24期Roleofinterleukin-1?inthepathogenesisofdiabeticretinopathy
...yabout80%andactivatedNF-Bby40%.Inthesamecellsapoptosiswasincreasedby70%andcaspase-3activitywasincreasedby40%.SupplementationofIL-1?in20mMglucosemediumfurtherincreasednitricoxideandNF-B,andacceleratedapoptosis,andadditionofIL-1rasignificantlydecreasedglucoseinducedabnormalitiesandapoptosis.Conclusion...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第10期InvestigationofaNosocomialOutbreakofImipenem-ResistantAcinetobacterbaumanniiProducingtheOXA-23-LactamaseinKorea
...ariousIMP-andVIM-typemetallo--lactamases(http://www.lahey.org/studies/webt.asp),butmostAcinetobacterspp.producezinc-independentmembersof-lactamasemolecularclassD(1).Sequencedcarbapenemasesofthislatterclassfromthatspeciesincludethefollowingtwodistinctclusters:(i)theOXA-23-likecluster(OXA-23and-27)and...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期Ratioofoleictopalmiticacidisadietarydeterminantofthrombogenicandfibrinolyticfactorsduringthepostprandialstateinmen
...inandmedium-chainsaturatedfattyacids(SFAs)]butnotfatscontaininglong-chainSFAsproduceshigherpostprandiallipemicresponsesthandoestheconsumptionofmonounsaturated(MUFA)andpolyunsaturated(PUFA)fattyacids(10,11).Thissuggeststhatthenatureofdietarylipidsmayhaveanimportantregulatoryroleintheactivationofthehe...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第2期AssessmentoftheRolesofSerines5.43(239)and5.46(242)forBindingandPotencyofAgonistLigandsattheHumanSerotonin5-HT2AReceptor
...etweentheligandamine(nonindole)nitrogenandthecarbonylcarbonofthesidechainofAsp3.32(155);2)aproteinhydrogenbondconstraintfortheside-chainoxygenofSer5.46(242);and3)aproteinhydrogenbondconstraintfortheside-chainOHhydrogenofSer5.43(239).Thelattertwoconstraintsfavorablyweightthescoringofdockingorientatio...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期Tetanization-inducedpelvic-to-pudendalreflexplasticityinanesthetizedrats
...PR).Thistetanization-inducedpotentiationwasabolishedbyaselectiveN-methyl-D-aspartate(NMDA)receptorantagonistandattenuatedbyanon-NMDAexcitatoryaminoacidreceptorantagonist.However,theGABAA-receptorantagonisthadnoeffectonthispotentiation.Bothintrathecalglutamate(0.1mM,2-5µlit)andNMDA(0.1mM,2-5&mi...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期SildenafilImprovesAlveolarGrowthandPulmonaryHypertensioninHyperoxia-inducedLungInjury
...t(Statview5.1;AbacusConcepts,Berkeley,CA).Statisticalsignificancewasdefinedasp0.05.RESULTSSildenafilPromotesVesselFormationInVitroInaninvitromodelofangiogenesis,HPAECformendothelialcord-likestructuresonMatrigel(Figure1).Hyperoxia(95%)significantlyreducedtheendothelialnetworkformationbyHPAECascompare...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第9期