ShiftsintargetingofclassswitchrecombinationsitesinmicethatlackμswitchregiontandemrepeatsorMsh2
...hetwomethods.TheCSRsitefrequencybetweentheHindIIIandXbaIsitesmightbeslightlyunderestimatedbecauseoftheH2HindIIIsiteintheCμsegment(Fig.2a).ForSμTR–/–mice,CSReventsoccurringdownstreamofH2wereestimatedusingtheHindIII-circularizedBcellDNAsamples.AmongSμTR–/–micewithCSRsiteslocateddownstreamof...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期AntibodiesfromPatientswithMelioidosisRecognizeBurkholderiamalleibutNotBurkholderiathailandensisAntigensintheIndirectHemagglutinationAssay
...al,UbonRatchathani,ThailandABSTRACTTheindirecthemagglutinationassayroutinelyusedtodetectantibodiestoBurkholderiapseudomalleiwasmodifiedtodetectcross-reactivityofantibodiestoB.pseudomallei,B.mallei,andB.thailandensisantigens.Wedemonstratealackofcross-reactivitybetweenB.pseudomalleiandB.thailandensisb...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期MolecularDiversityofBacillusanthracisinItaly
...ularechoesofthepastoutbreaks.FEMSMicrobiol.Lett.239:235-240.Henderson,I.,D.Yu,andP.C.Turnbull.1995.DifferentiationofBacillusanthracisandother‘Bacilluscereusgroup’bacteriausingIS231-derivedsequences.FEMSMicrobiol.Lett.128:113-118.Hoffmaster,A.R.,C.C.Fitzgerald,E.Ribot,L.W.Mayer,andT.Popovic.2002....
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期醫學分子病毒學綱要-KeyNotesonMedicalMolecularVirology——博學·研究生系列
...,andalistofreadingmaterialsissuggestedattheendofeachchapter.作者簡介:Yu-MeiWen,graduatedfromShanghaiFirstMedicalCollege,China,wasaWHOFellowatLondonSchoolofHygieneandTropicalMedicine,UK,andwasaFogartyFelIowatHepatitisVirusesSection,LaboratoryofInfectiousDiseases,NlAID,NationallnstitutesofHealth...
醫源資料庫;醫源書店;基礎醫學XBP-1specificallypromotesIgMsynthesisandsecretion,butisdispensablefordegradationofglycoproteinsinprimaryBcells
...itycontrolofnewlysynthesizedproteins(2–4).WhenproteinsemergeintotheER,theyundergoposttranslationalmodifications,suchasN-linkedglycosylationanddisulfidebondformation.Thesemodifications,assistedbyseveralchaperones,arerequiredforproperfoldingandassemblyofnewlysynthesizedERproteins.Whentheamountofclie...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第4期Miscuesonthe“lackofMEF2Amutations“incoronaryarterydisease
...disease:achangeofheart?J.Clin.Invest.115::831-833.doi:10.1172/JCI200524715.Yu,Y.T.1996..Distinctdomainsofmyocyteenhancerbindingfactor-2Adeterminingnuclearlocalizationandcelltype-specifictranscriptionalactivity.J.Biol.Chem.271::24675-24683.Bhagavatula,M.R.etal.2004..TranscriptionfactorMEF2Amutationsi...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第6期Essentialroleforinterleukin-2forCD4+CD25+Tregulatorycelldevelopmentduringtheneonatalperiod
...6AlthoughmanyaspectsofCD4+CD25+Tregulatory(Treg)celldevelopmentremainlargelyunknown,signalingthroughtheIL-2RrepresentsonefeaturefortheproductionofTregcells.Therefore,thepresentstudywasundertakentofurtherdefineearlydevelopmentalstepsintheproductionofTregcells,includingamorepreciseviewontheroleofinter...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期WorkloadDuetoAspergillusfumigatusandSignificanceoftheOrganismintheMicrobiologyLaboratoryofaGeneralHospital
...s95%CIarepresented.Weevaluatedthelinearincreaseintheprobabilityofinfectionbyusingthechi-squaretestfortrend.Thenullhypothesiswasrejectedineverycontrastofhypothesisforanalphaerrorof0.05.RESULTSFungalisolationandworkload.Duringthestudyperiod,therewere188,374hospitaladmissions,andthemicrobiologylaborato...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期AcuteHemorrhagicPericarditisinaChildwithPneumoniaDuetoChlamydophilapneumoniae
...at–20°C.DNAwaspreparedfromtwodifferentsamplingsofthepericardialeffusionbyuseofaQIAampDNAMinikit(QIAGEN,Hilden,Germany)andsimultaneouslysubjectedtoTaqManPCRsspecificfortheatypicalpneumoniae-causativeorganismsM.pneumoniae(P1adhesingene),Legionellapneumophilia(mipgene),andC.pneumoniae(rpoBgene).Asan...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第1期InducibleDNAbreaksinIgSregionsaredependentonAIDandUNG
...egionDNA,thusgeneratinguracils(8–12).UracilishypothesizedtothenbeexcisedbyuracilDNAglycosylase(UNG),leavinganabasicsite(8,13).Abasicsitescanberecognizedbyanapurinic/apyrimidic(AP)endonuclease(APEX1or2)thatnickstheDNAbackbone(8).CSRisreducedseverelyintheabsenceofUNG(13,14),butthefunctionofUNGhasbee...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第4期