Disease-associatedmutationsaffectintracellulartrafficandparacellularMg2+transportfunctionofClaudin-16
...arResearch,Charité,Berlin,Germany.AbstractClaudin-16(Cldn16)isselectivelyexpressedattightjunctions(TJs)ofrenalepithelialcellsofthethickascendinglimbofHenle’sloop,whereitplaysacentralroleinthereabsorptionofdivalentcations.Over20differentmutationsintheCLDN16genehavebeenidentifiedinpatientswithfamil...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第4期Deathbegetsfailureintheheart
...ascularResearchCenter,and2CancerCenter,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,USA.AddresscorrespondencetoRichardN.Kitsis,AlbertEinsteinCollegeofMedicine,1300MorrisParkAvenue,Bronx,NewYork10461,USA.Phone:(718)430-2609;Fax:(718)430-8989;E-mail:kitsis@aecom.yu.edu.AbstractRecently,low—butabnor...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期DifferentialSensitivitiesofSevereAcuteRespiratorySyndrome(SARS)CoronavirusSpikePolypeptideEnzyme-LinkedImmunosorbentAssay(ELISA)andSARSCorona
...fluorescenceassayandenzyme-linkedimmunosorbentassay(ELISA)usingcellcultureextracts(11,16).However,antibodydetectionbyindirectimmunofluorescenceassayusingcellcultureextractsmaybelessreproducible,moredifficulttostandardize,andmorelaborintensivethanELISA-basedantibodydetectiontestsusingrecombinantantig...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期InnateNKTlymphocytesconfersuperioradaptiveimmunityviatumor-capturingdendriticcells
...stigacionesBioquimicas3DepartamentodeQuímicaBiológica,FacultaddeCienciasExactasyNaturales,UniversidaddeBuenosAires,1650BuenosAires,Argentina4DivisionofCancerImmunology,DepartmentofPathology,OhioStateUniversityMedicalCenter,Columbus,OH43210Ifirradiatedtumorcellscouldberenderedimmunogenic,theywouldp...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第11期Trehalose‘-DimycolateandLipidinthePathogenesisofCaseatingGranulomasofTuberculosisinMice
...ehalose6,6‘-dimycolate(TDM)isthemostabundant,mostgranulomagenic,andmosttoxiclipidextractablefromthesurfaceofvirulentMycobacteriumtuberculosis(MTB).Wefurtherexamineditstoxicity,whichrequiresactivationbyoilysurfaces.InjectionsofMTBand/orTDMintosensitizedmiceinducedcaseatinggranulomasthatcenteredonoi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第4期AntigenrecognitionstrengthregulatesthechoicebetweenextrafollicularplasmacellandgerminalcenterBcelldifferentiation
...ustraliaBcellsrespondingtoT-dependentantigeneitherdifferentiaterapidlyintoextrafollicularplasmacellsorentergerminalcentersandundergosomatichypermutationandaffinitymaturation.However,thephysiologicalcuesthatdirectBcelldifferentiationdownonepathwayversustheotherareunknown.Hereweshowthatthestrengthofth...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期高效液相色譜法測定血清中蘆氟沙星及藥代動力學研究
...星血藥濃度,研究其藥代動力學過程。方法:用ODS柱(150x4.6mm),流動相爲0.03mol.L-1磷酸-乙晴-40%氫氧化四丁銨溶液(80:7:1,v/v)的混合液,吡哌酸爲內標物。結果:在0.4~4.0μg.ml-1範圍內呈良好的線性關係,迴歸方程爲Y=2.330X-0.100,r=0.9904,...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文Identifyinggenesthatregulateboneremodelingaspotentialtherapeutictargets
...micfactorsthatregulateosteoblastandosteoclastdifferentiationandfunction.Anexcessofresorptionoverformationleadstothebonelossandincreasedpropensitytofracturethatischaracteristicofosteoporosis.Anewlydescribedinhibitorofosteoblastdifferentiation,Ciz,interfereswithbonemorphogenicproteinsignaling.Asaconse...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期甲苯磺酸舒他西林分散片
...,妊娠及哺乳期婦女應慎用。 劑量:口服或用溫開水衝製成混懸液後口服。成人(包括老年人)及體重大於30公斤的兒童常用量一次0.375~0.75g,一日2次。兒童每日每公斤體重50mg,分2次服用。 標示量:應爲標示量的90.0...
藥品天地;專業藥學;藥品質量標準;西藥第三部分SmokingandElevatedBloodPressureAretheMostImportantRiskFactorsforSubarachnoidHemorrhageintheAsia-PacificRegion
...ityassociatedwithcommoncardiovascularriskfactorsintheAsia-PacificregionandexaminedwhetherthestrengthsoftheseassociationsweredifferentinAsianandAustralasian(predominantlywhite)populations.Methods—CohortstudieswereidentifiedfromInternetelectronicdatabases,searchesofproceedingsofmeetings,andpersonalc...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第7期