Deathbegetsfailureintheheart
...ocardialinfarction.However,currenttreatmentsforheartfailurearewoefullyinadequate,andtheavailabilityofheartsfortransplantationisseverelylimited.Eventhosetherapiesthatsuccessfullytargetbiologicallyrelevantpathways(e.g.,?-adrenergicreceptorblockers,angiotensin-convertingenzymeinhibitors)becomelesseffec...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期StructuralbasisforthefunctionandregulationofthereceptorproteintyrosinephosphataseCD45
...entwiththestructuralsimilarityofD2andD1,onlytwoaminoacidsubstitutionswererequiredtoconverttheotherwiseinertD2domainsofLARandPTPintoactiveenzymes(23–25).ThesefindingsledustoproposethatD2mightfunctionasanauxiliarycatalyticsitethatwouldbeactivatedunderspecificcellularconditionsorinthepresenceofaprope...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第3期InvivositesandcellularmechanismsofTregcell–mediatedsuppression
...tivationordifferentiationistargetedbyTregcellsremainunknown.Furthermore,arequirementfordirecteffectorTcell–Tregcellcontactinvivohasnotbeenascertained.Varyinganswerstotheseimportantquestionshavebeenprovidedbyseveralnewstudies.Duringthedecadesincetheirdiscovery,Tregcellshavebecomemajorculpritsforimm...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期AtrialnatriureticpeptidepromotescardiomyocytesurvivalbycGMP-dependentnuclearaccumulationofzyxinandAkt
...ialnatriureticpeptide(ANP)stimulationleadingtoelevationofcGMPlevelsandsubsequentnuclearaccumulationofAktkinaseassociatedwithzyxin,acytoskeletalLIM-domainprotein.NucleartargetingofzyxininducesresistancetocelldeathcoincidentwithnuclearaccumulationofactivatedAkt.NucleartranslocationofzyxintriggeredbycG...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期GeneticDiversityamongTypeemm28GroupAStreptococcusStrainsCausingInvasiveInfectionsandPharyngitis
...M5G1X5,CanadaNationalPublicHealthInstitute,Helsinki,FinlandABSTRACTGenomesequencingofgroupAStreptococcus(GAS)hasrevealedthatprophagesaccountforthevastmajorityofgenecontentdifferencesbetweenstrains.SerotypeM28strainsarealeadingcauseofpharyngitisandinvasiveinfections,butlittleisknownaboutgeneticdivers...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期DepartmentofMicrobiologyandImmunology,UniversityofMichiganMedicalSchool,AnnArbor,MI48109
...teredbysomatichypermutation(SHM;1),whichcausesamillion-foldincreaseinthefrequencyofpointmutationsoftheIg-variableregiongenes(2)andrareinsertionsanddeletions(3).CurrentparadigmsteachthatindividualclonesthencompeteforantigeninaDarwinianfashion,resultingintheclonalselectionofBcellsharboringreceptorsoft...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期壯骨顆粒對骨折癒合的影響
【摘要】 目的探討壯骨顆粒對骨折癒合的影響。方法新西蘭大白兔42只,於兔左側橈骨中段做3mm骨缺損,然後隨機分爲壯骨顆粒組、傷科接骨片組和生理鹽水組,術後1d開始給藥。在第4、6、8周進行X線觀察,第4、8周行病理...
醫源資料庫;在線期刊;齊魯醫學雜誌;2010年第25卷第4期IBkinase(IKK),butnotIKK,isacriticalmediatorofosteoclastsurvivalandisrequiredforinflammation-inducedboneloss
...Pathology,A-1030Vienna,AustriaTranscriptionfactor,nuclearfactorB(NF-B),isrequiredforosteoclastformationinvivoandmicelackingbothoftheNF-Bp50andp52proteinsareosteopetrotic.HereweaddresstherelativerolesofthetwocatalyticsubunitsoftheIBkinase(IKK)complexthatmediateNF-Bactivation,IKKandIKK,inosteoclastfor...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第10期IL-13R130Q,acommonvariantassociatedwithallergyandasthma,enhanceseffectormechanismsessentialforhumanallergicinflammation
...tedtoresultinthenonconservativereplacementofarginine130(R130)withglutamine(Q).WeexaminedtheimpactofIL13+2044GAonthefunctionalpropertiesofIL-13bydirectlycomparingtheactivityofWTIL-13andIL-13R130Qonprimaryhumancellsinvolvedintheeffectormechanismsofallergicinflammation.OurresultsshowthatIL-13R130Qwassi...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期AmongBcellnon-Hodgkin‘slymphomas,MALTlymphomasexpressauniqueantibodyrepertoirewithfrequentrheumatoidfactorreactivity
...s)bycomparing,attheaminoacidlevel,theirimmunoglobulin(Ig)VH-CDR3swithCDR3sequencespresentinGenBank.Follicularlymphomas,diffuselargeBcelllymphomas,Burkitt‘slymphomas,andmyelomasexpressedaCDR3repertoirecomparabletothatofnormalBcells.MantlecelllymphomasandBcellchroniclymphocyticleukemias(B-CLLs)expre...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期