藥物治療189例前列腺炎臨牀分析
...沙眼衣原體、解脲脲原體、支原體。 1.2微生物檢測結果(1)114例有菌生長:大腸埃希菌31例,葡萄球菌15例,不動桿菌9例,糞鏈球菌4例,布蘭漢卡他菌3例,L菌11例,淋球菌41例(其中淋球菌+沙眼衣原體3例,淋球菌+解脲脲...
醫源資料庫;在線期刊;中華現代外科學雜誌;2006年第3卷第1期利凡諾針配伍米索用於13~16w引產中200例臨牀觀察
...凡諾針100mg注入羊膜腔,術畢口服抗生素以防感染。 2結果 2.1兩組引產時間比較 見表1。表1兩組引產時間的比較例(略) A組引產時間明顯小於B組,明顯減少了13~16w內引產失敗率,減小感染率,13w左右的胎兒經A組處...
醫源資料庫;在線期刊;中華醫學研究雜誌;2006年第6卷第8期P2Y2receptor-mediatedreleaseofprostaglandinE2byIMCDisalteredinhydratedanddehydratedrats:relevancetoAVP-independentregulationofIMCDfunctio
...terpermeability(Pf)oftheinnermedullarycollectingduct(IMCD).ProstaglandinE2(PGE2)antagonizesvasopressin-inducedPfofIMCD.Previously,weshowedthatactivationofP2Y2receptor(P2Y2-R)inIMCDresultsinproductionandreleaseofPGE2,andP2Y2-RmRNAandproteinaresignificantlyelevatedininnermedullasofhydratedratscompared...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第10期PioglitazoneandRosiglitazoneDecreaseProstaglandinE2inNon–Small-CellLungCancerCellsbyUp-Regulating15-HydroxyprostaglandinDehydrogenase
...rcellselaboratetheimmunosuppressiveandantiapoptoticmediatorprostaglandinE2(PGE2),aproductofcyclooxygenase-2(COX-2)enzymeactivity.Becauseperoxisomeproliferator-activatedreceptor(PPAR)ligands,suchasthiazolidinediones(TZDs),inhibitlungcancercellgrowth,weexaminedtheeffectoftheTZDspioglitazoneandrosiglit...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期AntitumorigenicEffectsofPeroxisomeProliferator-ActivatedReceptor-inNon-Small-CellLungCancerCellsAreMediatedbySuppressionofCyclooxygenase-2via
...sshighlevelsofcyclooxygenase-2(COX-2)andproducehighlevelsofprostaglandinE2(PGE2).ThegoalofthesestudieswastoidentifythemolecularmechanismswherebyPPARinhibitstumorigenesis.IncreasedPPARinhibitedexpressionofCOX-2proteinandpromoteractivity,resultingindecreasedPGE2production.SuppressionofCOX-2wasmediated...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期前列腺素及其受體在發熱和急性炎症中的作用
...原位雜交的方法分析小鼠大腦中PGE受體亞型mRNA的表達,結果發現,儘管EP3受體的mRNA廣泛地分佈在小鼠大腦內,但它在圍繞OVLT的區域尤其豐富。而EP1受體的mRNA則在下丘腦的室旁核(PVH)和視上核有豐富的表達信號[8]。隨着各種...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2006年第6卷第8期DisruptionofcAMPandProstaglandinE2TransportbyMultidrugResistanceProtein4DeficiencyAlterscAMP-MediatedSignalingandNociceptiveResponse
...Ainterference-mediatedmrp4knockdownledtoapronouncedreductioninextracellularPGE2butwithnoaccumulationofintracellularPGE2inMEFcells.ThisresultwasconsistentwithattenuatedcAMP-dependentproteinkinaseactivityandreducedcyclooxygenase-2(Cox-2)expressioninmrp4-deficientMEFcells,suggestingthatPGsynthesisisres...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期DifferentialRegulationofPhosphorylationofthecAMPResponseElement-BindingProteinafterActivationofEP2andEP4ProstanoidReceptorsbyProstaglandin
...etheactivationofphosphatidylinositol3-kinase(PI3K).Inthisstudy,wereportthatPGE2stimulationofcellsexpressingeithertheEP2orEP4receptorresultsinthephosphorylationofthecAMPresponseelementbindingprotein(CREB)atserine-133.PretreatmentofcellswithN-[2-(4-bromocinnamylamino)ethyl]-5-isoquinoline(H-89),aninhi...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第1期CXCL1inducedbyprostaglandinE2promotesangiogenesisincolorectalcancer
...ell-knownriskfactorforcancer.ProinflammatorymediatorssuchasprostaglandinE2(PGE2)promotecolorectaltumorgrowthbystimulatingangiogenesis,cellinvasion,andcellgrowth,andinhibitingapoptosis.Moleculesthatregulatetumor-associatedangiogenesisprovidepromisingtherapeutictargetsfortreatmentofcolorectalcancer(CR...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期AdenylylCyclase6OverexpressionDecreasesthePermeabilityofEndothelialMonolayersviaPreferentialEnhancementofProstacyclinReceptorFunction
...llsandreleaseandrespondtovasoactiveagents,includingprostaglandins(PGs;e.g.,PGE2,PGI2,PGD2,andPGF2)thathavespecificityforsubtypesofPGreceptors(EP1-4,IP,DP,andFP,respectively)(Breyeretal.,2001).CertainPGreceptorsubtypes,EP2,4,IP,andDP,areGs-linkedand,uponstimulation,activateACtoincreaseintracellularcA...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期