水蛭素的研究進展及其在抗凝治療中的應用
...它作爲受體引導血小板聚集。位於纖維蛋白原上的Arg-Gly-Asp(RGD)序列是血小板GPⅡb/Ⅲa複合物的識別位點,兩者的結合是血栓形成的最後通路,所以阻斷該環節是防治血栓形成的新途徑。研究表明含RGD序列的外源性多肽可抑制...
合作平臺;在線期刊;中華中西醫雜誌;2004年第5卷第2期;綜述脂質體作爲血栓性疾病藥物載體的研究進展
...成。王向濤等[15]合成靶向於血栓的特異性配體H-Arg-Gly-Asp-Se-OH(RGDS)和DSPE-PEG3500偶聯後插入到脂質體雙層膜中得到血栓靶向尿激酶脂質體,並在大鼠頸總動脈血栓模型上考察了此脂質體的體內溶栓效果。結果顯示,遊離尿激...
合作平臺;在線期刊;中華醫藥雜誌;2005年第5卷第2期;綜述與講座脫細胞真皮基質體內轉歸的研究進展
...性纖維成熟並按照正常皮膚形式排列,實現臨牀癒合。Gaspar等[3]將ADM直接置於重度燒傷後暴露的骨面,表面再覆蓋半厚皮片,術後2年組織學觀察,上皮顯示正常的結構和角化;在上皮與真皮連接處有中等數量的疏鬆膠原纖維;...
醫源資料庫;在線期刊;濱州醫學院學報;2008年第31卷第1期ProteinKinaseC-DependentMitochondrialTranslocationofProapoptoticProteinBaxonActivationofInducibleNitric-OxideSynthaseinRostralVentrolateralM
...overproductionofnitricoxide(NO)byinducibleNOsynthase(iNOS)inRVLM,leadingtocaspase3-dependentapoptoticcelldeath,playsapivotalroleincardiovasculardepressionduringendotoxemiainducedbyintravenousadministrationofEscherichiacolilipopolysaccharide.Theinterposingintracellulareventsremainunknown.Weevaluatedt...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期StructuralRequirementsofTransmembraneDomain3forActivationbytheM1MuscarinicReceptorAgonistsAC-42,AC-260584,Clozapine,andN-Desmethylclozapine:
...ingisasaltbridgebelievedtoexistbetweenthecholineheadgroupofacetylcholineandaspartate105(Asp105)inTM3.Thisresiduereactedwiththeaffinitylabelacetylcholinemustard,inwhichtheoniumheadgroupofacetylcholineisreplacedbyahighlyreactiveaziridiniumgroup(Spaldingetal.,1994),demonstratingthatthismoietywasphysica...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期ConcurrentAdministrationofNeu2000andLithiumProducesMarkedImprovementofMotorNeuronSurvival,MotorFunction,andMortalityinaMouseModelofAmyot
【關鍵詞】ConcurrentTheFaspathwayandoxidativestressmediateneuronaldeathinstrokeandmaycontributetoneurodegenerativedisease.Wetestedthehypothesisthatthesetwofactorssynergisticallyproducespinalmotorneurondegenerationinamyotrophiclateralsclerosis(ALS).Levelsofreactiveoxygenspecieswereincreasedinmot...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期UseofPCRAnalysesToDefinetheDistributionofRalstoniaSpeciesRecoveredfromPatientswithCysticFibrosis
...iganMedicalSchool,AnnArbor,Michigan48109ABSTRACTTwonewPCRassays(forRalstoniaspeciesandRalstoniarespiraculi),togetherwithpreviouslypublishedPCRassays,wereusedtoassessRalstoniaisolatesrecoveredfrom111cysticfibrosispatients.Ralstoniamannitolilyticaaccountedfor46%ofisolates,whileR.respiraculiandRalstoni...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期Defendingscienceeducationagainstintelligentdesign:acalltoaction
...hishassparkedarenaissanceofinterestinspeciation,development,andevolutionaryaspectsofdiseasesusceptibilityandresistance.TheimportanceofevolutiontobiologywasproperlysummarizedbyWhiteHouseScienceAdviserJohnMarburgerwhenhesaid,“Evolutionisthecornerstoneofmodernbiology.Period.Whatelsecanyousay?“(1).I...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期ComparisonoftheActivitiesoftheTruncatedHalichondrinBAnalogNSC707389(E7389)withThoseoftheParentCompoundandaProposedBindingSiteonTubuli
...unds.IsolatedfromthespongesHalichondriaokadai(HirataandUemura,1986),Axinellaspecies(Pettitetal.,1991),andLissodendoryxspecies(Litaudonetal.,1997),halichondrinBisapotentantimitoticagentthatinhibitstubulinassembly(Baietal.,1991).Becauseitinhibitsthebindingofradiolabeledvinblastinetotubulininanoncompet...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期丙型肝炎病毒絲氨酸蛋白酶基因的克隆和表達
...生無義突變。絲氨酸蛋白酶催化中心三聯體基序His-1083,Asp-1107,Ser-1165,及上述與蛋白酶活性密切相關的位點,在我們克隆的片段中均高度保守。 我們將擴增的HCV絲氨酸蛋白酶基因克隆至原核表達載體pBV220,經溫控誘導後,...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學