HPLC法測定固體藥物含量的不確定度評定

...釋到刻度，搖勻。1.5.2樣品溶液的配製精密稱取樣品2份（WT1=1866.8mg，WT2=1856.4mg），分別置於2個100ml量瓶中（a=±0.1），加流動相溶解並稀釋到刻度，搖勻。　　2結果2.1峯面積S1：1922587、1924341、1924112；S2：1988372、1980980、1983488...

共刺激分子B7-1與IL-6協同誘導T細胞活化的研究①

...ld-type,mock-transfected,andmurineB7-1cDNA-transfectedB16melanomacells(B16-wt,B16-neo,andB16-mB7.1)respectivelyforsixdays,thelymphocytesweretestedforbothproliferationindicesandcytotoxicactivityagainstB16-wtcells.Results：ComparedwithB16-wtorB16-neocells,B16-mB7.1cellsmoreeffectivelyinducedtheprolif...

Thrombin-ActivatableFibrinolysisInhibitorDeficiencyAttenuatesBleomycin-InducedLungFibrosis

...nactivationmarker(thrombin-antithrombincomplex),totalsolublecollagen,andgrowthfactors(platelet-derivedgrowthfactor,transforminggrowthfactor-ß1,granulocytic-macrophagegrowthfactor)weresignificantlydecreasedinknockoutmicecomparedtowild-typemice.Further,histologicalfindingsoffibrosis,fibrindeposi...

PPARGeneTransferSustainsApoptosis,InhibitsVascularSmoothMuscleCellProliferation,andReducesNeointimaFormationAfterBalloonInjuryinRats

...ationafterballooninjury,wedeliveredadenoviralvectorsexpressingthewild-type(WT)dominantnegative(DN)PPAR,oracontrolgene(ß-galactosidase)intocarotidarteryafterballooninjuryinrosiglitazone(aPPARligand)-treated(R+)(3mg/kg/d)andnontreated(R-)rats.Twoweeksaftergenedelivery,inbothR+andR-animals,thePPA...

A1adenosinereceptorknockoutmiceexhibitincreasedrenalinjuryfollowingischemiaandreperfusion

...pproachesinmice.A1ARknockoutmice(A1KO)ortheirwild-typelittermatecontrols(A1WT)weresubjectedto30minofrenalischemia.SomeA1WTmiceweresubjectedto30minofrenalischemiawithorwithoutpretreatmentwith1,3-dipropyl-8-cyclopentylxanthine(DPCPX)or2-chrolo-cyclopentyladenosine(CCPA),selectiveA1ARantagonistandagoni...

RasGRP1ConfersthePhorbolEster-SensitivePhenotypetoEL4LymphomaCells

...,PMAcausesrobustErkmitogen-activatedproteinkinaseactivationthatresultsingrowtharrest.Inresistantcells,PMAinducesminimalErkactivation,withoutgrowtharrest.PMAstimulatesIL-2productioninsensitive,butnotresistant,cells.TheroleofRasGRP1,aPMA-activatedguaninenucleotideexchangefactorforRas,inEL4phenotypewas...

IX因子變體提高血友病B的基因治療效率

...親和力的變體）後，其血液循環中的F.IX水平是野生型（WT）F.IX的2至5倍，但是兩者的蛋白特異性活動卻是相似的。當載體運輸至骨骼肌或肝臟後，F.IX-R338A產生的蛋白是F.IX-WT所產生的2或6倍。F.IX-WT及變體在活體止血效果上向後沿...

代謝性穀氨酸受體在脆性X綜合徵樹突棘發育中的作用

...劑治療的機制。研究者培養FMR-1基因敲除小鼠(KO)和野生(WT)小鼠海馬神經元，給予mGluR-Ⅰ激動劑和拮抗劑進行處理，Western-Blot法檢測處理前後脆性X智力低下蛋白(FMRP)和微管相關蛋白1B(MAP1B)，共聚焦顯微鏡觀察樹突棘的長度和密度...

胸部CT評估重度COPD的氣道及肺氣腫病變

...)佔整個肺野面積的百分比(ＬＡＡ%)、10mm周長氣道壁厚度(WT)及氣道面積佔氣道橫截面積的平方根(SRWA)。分析後發現，ＬＡＡ%與WT(r=-0.28,p=0.0001)和SRWA(r=-0.19,p=0.0008)呈負相關；WT與支氣管擴張劑後的FEV1%預計值相關(R=-0.12,p=0.02)；多因...

FunctionalCharacterizationofConnexin43MutationsFoundinPatientsWithOculodentodigitalDysplasia

...dK134EdemonstratedasignificantdecreaseinjunctionalconductancerelativetoCx43WT.MutationsY17S,G21R,andA40Vdemonstratedacompletelackoffunctionalelectricalcouplingeveninthepresenceofsignificantplaqueformationbetweenpairedcells.HeterologouschannelsformedbycoexpressionofCx43WTandmutationR202Hresultedinele...