小劑量甲狀腺素對在體大鼠B細胞凋亡研究
【摘要】目的觀察甲狀腺素對SD大鼠胰島B細胞凋亡核苷酸、Caspase-3、Bcl-2的影響,以闡明甲狀腺功能亢進時合併糖尿病或葡萄糖耐量降低的可能病理機制。方法末端標記dUTP(TUNEL)法觀察SD大鼠胰島B細胞凋亡核苷酸、免疫組織化...
醫源資料庫;在線期刊;中華現代內科學雜誌;2006年第3卷第4期PartialExcisionoftheChromosomalCassetteContainingtheMethicillinResistanceDeterminantResultsinMethicillin-SusceptibleStaphylococcusaureus
...ity,NewYork,NewYork10021ABSTRACTWereportadetailedcharacterizationofmethicillin-susceptibleStaphylococcusaureusisolatesfromfiveFrenchhospitalsnegativeforboththemecAandtheccrABlocibutpositivefortheIS431::pUB110::IS431::dcsstructure,presentinsomeStaphylococcuscassettechromosomemec(SCCmec)types.Theprese...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期GeneticDiversityofMultidrug-ResistantMycobacteriumtuberculosisIsolatesandIdentificationof11NovelrpoBAllelesinTaiwan
...tofHealthTaipeiMedicalUniversity-MunicipalWanFangHospital,TaipeiDivisionofClinicalResearch,NationalHealthResearchInstitutes,Tainan,Taiwan,RepublicofChinaInternationalUnionAgainstTuberculosisandLungDisease,Paris,FranceABSTRACTOf162multidrug-resistantMycobacteriumtuberculosisisolatesfromTaiwan,60.5%we...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期InactivationofthePRDM1/BLIMP1geneindiffuselargeBcelllymphoma
...inunclassified(6).Anadditionalclassification,alsobasedongeneexpressionprofiling,identifiedthreediscretesubsetsdefinedbytheexpressionofgenesinvolvedinoxidativephosphorylation(OXP),BCR/proliferation(BCR),ortumormicroenvironment/hostinflammatoryresponse(HR)(7).Consistentwiththisheterogeneity,thegenetic...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期HistonedeacetylaseactivityisessentialfortheexpressionofHoxA9andforendothelialcommitmentofprogenitorcells
...0133Milan,ItalyTheregulationofacetylationiscentralfortheepigeneticcontroloflineage-specificgeneexpressionanddeterminescellfatedecisions.Weprovideevidencethattheinhibitionofhistonedeacetylases(HDACs)blockstheendothelialdifferentiationofadultprogenitorcells.TodefinethemechanismsbywhichHDACinhibitionpr...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第11期Laboratory-BasedSurveillanceandMolecularEpidemiologyofInfluenzaVirusinTaiwan
...ityHospital,TaichungTaiwanABSTRACTAlaboratory-basedsurveillancenetworkof11clinicalvirologicallaboratoriesforinfluenzaviruseswasestablishedinTaiwanunderthecoordinationoftheCenterforDiseaseControlandPrevention(CDC),Taiwan.FromOctober2000toMarch2004,3,244influenzaviruseswereisolated,including1,969influ...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期B-LymphocyteDepletionReducesSkinFibrosisandAutoimmunityintheTight-SkinMouseModelforSystemicSclerosis
...(43%)thedevelopmentofskinfibrosis,autoantibodyproduction,andhypergammaglobulinemia.B-celldepletionalsorestoredamorenormalbalancebetweenTh1andTh2cytokinemRNAexpressionintheskin.Bycontrast,B-celldepletiondidnotaffectskinfibrosis,hypergammaglobulinemia,andautoantibodylevelsinadultmicewithestablisheddis...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第9期一種新的共刺激信號CD137在人T細胞及其亞羣中的表達特點①
一種新的共刺激信號CD137在人T細胞及其亞羣中的表達特點①中國免疫學雜誌1999年第10期第15卷分子與細胞免疫學作者:張利寧 曹英林 馬春紅 宋靜 趙文璞 朱長軍 孫汶生關鍵詞:T細胞;共刺激信號,,CD137;免疫細胞化學...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學RegulationoftheenergysensorAMP-activatedproteinkinasebyantigenreceptorandCa2+inTlymphocytes
...ATP).However,TCRandCa2+stimulationofAMPKrequiredtheactivityofCa2+–calmodulin-dependentproteinkinasekinases(CaMKKs),whereasAMPKactivationinducedbyincreasedAMP/ATPratiosdidnot.TheseexperimentsrevealtwodistinctpathwaysfortheregulationofAMPKinTlymphocytes.TheroleofAMPKistopromoteATPconservationandprod...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期ActivationoftheFlt3signaltransductioncascaderescuesandenhancestypeIinterferon–producinganddendriticcelldevelopment
InstituteforResearchinBiomedicine,CH-6500Bellinzona,SwitzerlandFlt3ligand(Flt3L)isanonredundantcytokineintypeIinterferon–producingcell(IPC)anddendriticcell(DC)development,andIPCandDCdifferentiationpotentialisconfinedtoFlt3+hematopoieticprogenitorcells.Here,weshowthatoverexpressionofhumanFlt3inFlt3...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期