Antiviraldefense:interferonsandbeyond
...ackingtheadaptorproteinthatinitiatesanantiviralresponsedownstreamoftheRNAhelicasesretinoicacid–induciblegeneI(RIG-I)andmelanomadifferentiation-associatedgene5(MDA5)haverecentlybeendescribed.ThesestudieshighlighttheessentialandnonredundantroleofnucleicacidrecognitionintheinductionoftypeIinterferonp...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期Thestemcellnichesinbone
...calCenter,KansasCity,Kansas,USA.AbstractThestemcellnicheiscomposedofaspecializedpopulationofcellsthatplaysanessentialroleinregulatingadultstemcellself-renewalanddifferentiation.Inadults,osteoblasts,responsibleforosteogenesis,andhematopoieticcells,responsibleforhematopoiesis,arecloselyassociatedinthe...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期RoleofHMGB1inapoptosis-mediatedsepsislethality
...esepsis,alethalsyndromeafterinfectionorinjury,isthethirdleadingcauseofmortalityintheUnitedStates.Thepathogenesisofseveresepsisischaracterizedbyorgandamageandaccumulationofapoptoticlymphocytesinthespleen,thymus,andotherorgans.Toexaminethepotentialcausalrelationshipsofapoptosistoorgandamage,weadminist...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期ERK1/2信號通路對T淋巴細胞的影響
ERK1/2信號通路對T淋巴細胞的影響(pdf)[摘要]細胞外信號調節激酶1/2(extracellularregulatedkinase1/2,ERK1/2)是將信號從細胞表面受體傳導至細胞核的關鍵。磷酸化的ERK1/2由胞質轉位到核內,進而介導NF-AT、AP-1、NF-κB等轉錄因子的活化,...
醫源資料庫;在線期刊;中華現代內科學雜誌;2006年第3卷第12期流式細胞儀檢測健康兒童T淋巴細胞亞羣及其絕對計數的研究
【摘要】目的建立健康兒童T淋巴細胞亞羣及其絕對計數的正常參考值。方法採用流式細胞術,通過四色熒光標記,在絕對計數管(TruCounttube)內進行T淋巴細胞亞羣的檢測及絕對計數分析。結果健康兒童T淋巴細胞(CD3+細胞羣體...
資料庫;在線期刊;中華現代兒科學雜誌;2005年第2卷第7期新型藥物BBI608應用於晚期癌症患者的臨牀實驗
...正在研究開發一種新類型的癌症藥物,它通過針對某些癌細胞的類似於幹細胞的屬性起作用。迄今爲止,一場正在進行的I期臨牀試驗的結果顯示了強有力的安全性和臨牀活性的早期跡象。“癌症幹細胞可以說代表了今天的癌症...
行業資訊;臨牀快報;腫瘤相關GeneticVariantsofArachidonate5-Lipoxygenase–ActivatingProtein,andRiskofIncidentMyocardialInfarctionandIschemicStroke
...rdMedicalSchool,Boston,MasstheRocheMolecularSystems(S.C.,H.A.E.),Alameda,Calif.AbstractBackgroundandPurpose—Recentfindingshaveimplicatedspecificgenepolymorphismsofarachidonate5-lipoxygenase–activatingprotein(ALOX5AP),and2at-riskhaplotypes(HapA,HapB)inmyocardialinfarctionandstroke.Todate,noprospe...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第8期NovelAntibody-LectinEnzyme-LinkedImmunosorbentAssayThatDistinguishesPrionProteinsinSporadicandVariantCasesofCreutzfeldt-JakobDisease
...thesethreegroupswerecompared,nosignificantdifferenceinthebindingofconcanavalinAorAleuriaaurantialectinwasdetected.However,thebindingofRicinuscommunisagglutininI(RCA)tosCJDandvCJDsampleswassignificantlyincreased.Incontrast,whenonlytruncatedPrPspecieswerecompared,onlyvCJDsampleshadmoreRCAbindingactivi...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第3期高效液相色譜儀(HPLC)的校正(1)
...段梯度誤差Gci,取最大作爲儀器梯度誤差,公式:Gci=(Li—Lm)/Lm×100% Li:第i段信號值的平均值;Lm-:各段輸出信號平均值的平均值 可接受標準:-3%≤Gci≤3% 2.2、泵流量設定值誤差Ss、流量穩定性誤差SR的校正 2.2....
藥品天地;專業藥學;實驗技術;色譜技術;儀器安裝、維修與保養ReawakeningthecellulardeathprograminneoplasiathroughthetherapeuticblockadeofIAPfunction
...s(IAP)proteinfamilyarehighlyexpressedinseveralclassesofcancer.TheprimaryimplicationofthesefindingsisthattheelevatedexpressionofIAPsisnotcoincidentalbutactuallyparticipatesinoncogenesisbyhelpingtoallowthemalignantcelltoavoidapoptoticcelldeath.Thisconcept,togetherwiththediscoveryofseveralIAP-regulator...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期