RelationBetweentheMetabolicSyndromeandIschemicStrokeorTransientIschemicAttack
...nce.Patientswithpreviouslydiagnoseddiabetesorwithafastingplasmaglucoselevel125mg/dL(7.0mmol/L)wereconsidereddiabetic.Results—Thestudysamplecomprised14284patients,ofwhich3703(26%)fulfilledthecriteriaforthemetabolicsyndromewithoutdiabetesand3500others(25%)thecriteriafordiabetes.Adjustingforstrokeris...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第7期PioglitazoneStimulatesApolipoproteinA-IProductionWithoutAffectingHDLRemovalinHepG2Cells
...HDLtotalproteinwascarriedoutbyincubatingfreshlyisolatedHDL3withcarrier-free125I.22Aftertheiodination,unreacted125IwasremovedbygelfiltrationfollowedbyexhaustivedialysisagainstPBS.UptakestudieswereinitiatedbypreincubatingHepG2cellswithvaryingconcentrationsofpioglitazone(0to10µmol/L)for48hoursat3...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期DevelopmentalRegulationofp66ShcIsAlteredbyBronchopulmonaryDysplasiainBaboonsandHumans
...stochemistry.MeasurementsandMainResults:Inbaboons,p66Shcdecreased80%between125and175days‘gestation(p=0.025),thendoubledaftertermdeliveryat185days(p=0.0013).Inthehyperoxic140-dayfetalbaboonBPDmodel,p66Shcexpressionpersisted,anditslocalizationshiftedfromtheepitheliumofgestationalcontrolstothemesench...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第6期InsulinFacilitatestheHepaticClearanceofPlasmaAmyloidβ-Peptide(1–40)byIntracellularTranslocationofLow-DensityLipoproteinReceptor-RelatedProtei
...oninwholelysatewasnotaffectedbyinsulintreatment.Theapparenthepaticuptakeof[125I]Aβ(1–40)wasalsoinducedbyinsulininatime-dependentmanner.Theincreasein[125I]Aβ(1–40)uptakebyinsulinwasconcentration-dependent(EC50=230pM)andwascompletelyabolishedbyreceptor-associatedprotein(2µM...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期125碘粒子植入聯合射頻消融前列腺癌治療術後PSA變化
【摘要】目的評估125碘粒子永久植入聯合巨能射頻消融治療前列腺癌術後PSA變化,觀察PSA的臨牀意義。方法在直腸B超引導下,經會陰模板穿刺將125碘粒子植入到靶組織中,再行巨能射頻消融,治療前列腺癌病人12例。術後測定PSA...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第7B期PeroxynitriteDiminishesMyogenicActivityandIsAssociatedWithDecreasedVascularSmoothMuscleF-ActininRatPosteriorCerebralArteries
...tionofspontaneoustoneandlossofmyogenicactivityinthephysiologicalrangeof50to125mmHg,increasingdiameterfrom130±6to201±5μmat75mmHg(P0.01).Inaddition,thediminishedmyogenicactivitywasassociatedwitha4.5-folddecreaseinF-actincontentofVSManda27%increaseinG-actincontent(P0.01).Conclusions—Thisstudydemon...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第3期NeuropeptideFF(NPFF)AnalogsFunctionallyAntagonizeOpioidActivitiesinNPFF2Receptor-TransfectedSH-SY5YNeuroblastomaCells
.../mmol)werepurchasedfromAmershamBiosciencesInc.(St.QuentinFallavier,France).125I-EYFand125I-deltorphin-Iwereiodinatedbyelectrophilicsubstitution,asdescribedpreviously(Gouardeeresetal.,2001).CellCulture.HumanneuroblastomaSH-SY5YcellswerekindlyprovidedbyF.Noble(UniversiteeReneeDescartes,Paris,France).C...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期Relaxin-3/Insulin-LikePeptide5ChimericPeptide,aSelectiveLigandforGProtein-CoupledReceptor(GPCR)135andGPCR142overLeucine-RichRepeat-Containing
...frelaxin-3)withaveryhydrophilicpeptide(theA-chainfromINSL5),theradiolabeled125I-relaxin-3/INSL5chimeraisasuitableligand(high-affinity,low-nonspecificbinding)forreceptorautoradiographicstudiesontissuesections.Relaxin-3(Bathgateetal.,2002),thenewestmemberoftherelaxin(Hudsonetal.,1983,1984)/insulinsupe...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第1期StimulationofLiver-DirectedCholesterolFluxinMicebyNovelN-Acetylgalactosamine-TerminatedGlycolipidsWithHighAffinityfortheAsialoglycoproteinRec
...O).25AssociationofLCO-Tyr-GalNAc3WithLipoproteinsSerawereincubatedwithLCO-[125I]Tyr-GalNAc3andelectrophoresedonagarosegels.LipidswerevisualizedbySudanblackand125IactivityusingaPackardInstantImager.KineticStudiesinMiceMicewereanesthetized,19andkineticstudieswithradiolabeledlipoproteinswereperformedas...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第1期ExpressionofNigrostriatal6-ContainingNicotinicAcetylcholineReceptorsIsSelectivelyReduced,butNotEliminated,by3SubunitGeneDeletion
...expressed.3subunitincorporationseemedtoincrease4participationin62complexes.125I-Epibatidinecompetitionbindingstudiesshowedthatthe-CtxMIIaffinityof6nAChRsfromthestriataof3eC/eCmicewassimilartothoseisolatedfrom3+/+animals.Together,theresultsoftheseexperimentsshowthatthe3subunitisimportantforthecorrect...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期