非受體蛋白酪氨酸激酶Tec家族的研究進展
...t、Tec、Txk和Bmx,其結構具有高度同源性,均由PH結構域、SH3、SH2及激酶結構域組成,其N端缺乏疏水性跨膜結構,而C端缺乏負性調節區。它們所介導的信號轉導主要在免疫細胞的分化、發育、增殖和凋亡過程中起着重要的作用。...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學ReactiveOxygenSpeciesandp38Mitogen-ActivatedProteinKinaseActivateBaxtoInduceMitochondrialCytochromecReleaseandApoptosisinResponsetoMalona
...oxintostudyneurodegenerationinHuntington‘sdiseaseandischemicstroke.Wehaveshownpreviouslythatmalonateincreasedreactiveoxygenspecies(ROS)productioninhumanSH-SY5Yneuroblastomacells,leadingtooxidativestress,cytochromecrelease,andapoptoticcelldeath.Expressionofagreenfluorescentprotein-Baxfusionproteini...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期CystamineandcysteamineincreasebrainlevelsofBDNFinHuntingtondiseaseviaHSJ1bandtransglutaminase
...mineisacandidatedrug;however,themechanismsbywhichitoperatesremainunclear.WeshowherethatcystamineincreaseslevelsoftheheatshockDnaJ-containingprotein1b(HSJ1b)thatarelowinHDpatients.HSJ1binhibitspolyQ-huntingtin–induceddeathofstriatalneuronsandneuronaldysfunctioninCaenorhabditiselegans.Thisneuroprote...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期NeuropeptideFF(NPFF)AnalogsFunctionallyAntagonizeOpioidActivitiesinNPFF2Receptor-TransfectedSH-SY5YNeuroblastomaCells
...mofthecellularantiopioidactivityofneuropeptideFF(NPFF),wehavetransfectedtheSH-SY5Yneuroblastomacellline,whichexpressese?and-opioidreceptors,withthehumanNPFF2receptor.Theselectedclone,SH2-D9,expressedhigh-affinityNPFF2receptorsinthesamerangeorderase?and-opioidreceptors(100eC300fmol/mgofprotein).TheNP...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期胺碘酮致尖端扭轉性室速1例報告
...置,Q-T0.57s(見圖1),查血鉀2.8mmol/L,轉入CCU病房,給予補鉀、擴冠,繼續口服胺碘酮0.2g3次/日治療,轉入後第2日(8月15日)患者再發暈厥,心電示波:Q-T間期0.65s~0.76s,繼而呈現尖端扭轉性室速(Tdp)(見圖2),予同步直流...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第6B期MolecularIdentificationofMumpsVirusGenotypesfromClinicalSamples:StandardizedMethodofAnalysis
...s,ArgentinaABSTRACTAsensitivenestedreversetranscription-PCRassay,targetingashortfragmentofthegeneencodingthesmallhydrophobicprotein(SHgene),wasdevelopedtoallowrapidcharacterizationofmumpsvirusinclinicalsamples.ThesensitivityandspecificityoftheassaywereestablishedusingrepresentativegenotypesA,B,C,D,E...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期MTA1在化療後骨肉瘤中的表達及其與預後的關係
...eflecttheinvasive,metastaticbiologicalactivitiesoftheresidualtumorcells.ItishelpfultodetectMTA1expressionfortheprognosisofpatientswithosteosarcoma. Keywords:osteosarcoma;neoadjuvantchemotherapy;MTA1;prognosis 腫瘤轉移相關基因1(metastasisassociated1,MTA1)是新近發現的一個...
醫源資料庫;在線期刊;中國矯形外科雜誌;2009年第17卷第3期STAT3的作用與腫瘤
...有特異性針對活性IFN-γ迴文序列(GAS)元件的序列;(3)SH3結構域:位於第500~600位氨基酸,能與富含Pro的基序(motif)結合;(4)SH2區:參與受體恢復和STAT的二聚體化;(5)C-末端轉錄激活結構域:在轉錄激活域內的色氨酸(S727)或...
合作平臺;在線期刊;中華實用醫藥雜誌;2004年第4卷第14期;綜述第四節 G蛋白和磷脂酶C
...細胞極化(polarization)和抗原的提呈。某些信號蛋白通過SH-3功能區將酪氨酸激酶途徑同一些由小G蛋白所控制的途徑連接起來,如Rho(與Ras有30%同源性)調節胞漿中微絲上肌動蛋白的聚合或解離,從而影響細胞形態。這一事實解...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學FunctionalinfluenceofN-glycosylationinOCT2-mediatedtetraethylammoniumtransport
...nceglycosylationhasonOCT2function,remainsunknown.Toaddresstheseissues,theacquisitionofN-glycosylationwasdisruptedbymutatingtheaminoacidasparagine(N)toglutamine(Q)atthesesitesintherabbitorthologofOCT2,whichwasexpressedinChinesehamsterovarycells.DisruptionofN-glycosylationfollowedbyWesternblottingindi...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第5期