IL-13R130Q,acommonvariantassociatedwithallergyandasthma,enhanceseffectormechanismsessentialforhumanallergicinflammation
...wntostronglyinfluencesusceptibilitytoallergicinflammation.TheTh2cytokineIL-13isacentralmediatorofallergyandasthma,andcommonsingle-nucleotidepolymorphismsinIL13areassociatedwithallergicphenotypesinseveralethnicallydiversepopulations.Inparticular,IL13+2044GAisexpectedtoresultinthenonconservativereplac...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期ERK1/2mitogen-activatedproteinkinaseselectivelymediatesIL-13–inducedlunginflammationandremodelinginvivo
...epartmentofPathology,UniversityofVermont,Burlington,Vermont,USA.AbstractIL-13dysregulationplaysacriticalroleinthepathogenesisofavarietyofinflammatoryandremodelingdiseases.Inthesesettings,STAT6isbelievedtobethecanonicalsignalingmoleculemediatingthetissueeffectsofIL-13.SignalingcascadesinvolvingMAPKsh...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第1期ShigatoxintriggersthromboticthrombocytopenicpurpuraingeneticallysusceptibleADAMTS13-deficientmice
...isalife-threateningillnesscausedbydeficiencyofthevWF-cleavingproteaseADAMTS13.HereweshowthatADAMTS13-deficientmiceareviableandexhibitnormalsurvival,althoughvWF-mediatedplatelet-endothelialinteractionsaresignificantlyprolonged.IntroductionofthegeneticbackgroundCASA/Rk(amousestrainwithelevatedplasmavW...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期SystemicantithromboticeffectsofADAMTS13
...Arbor,MI481094BaxterBioscience,Vienna,A-1220AustriaThemetalloproteaseADAMTS13(adisintegrin-likeandmetalloproteasewiththrombospondintypeIrepeats13)cleaveshighlyadhesivelargevonWillebrandfactor(VWF)multimersaftertheirreleasefromtheendothelium.ADAMTS13deficiencyislinkedtoalife-threateningdisorder,throm...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期ObligatoryRoleforInterleukin-inObstructiveLesionDevelopmentinAirwayAllografts
...blasts,whichstronglyexpressedthesignalingchainofthehighaffinityinterleukin-13(IL-13)receptorIL-13R1.BecauseIL-13hasproinflammatoryandprofibroticactions,acontributoryroleforIL-13inBOdevelopmentwasexaminedusingmurinemodelsoforthotopicandheterotopictrachealtransplantation.Comparedwithairwayisografts,al...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期MMP13mutationcausesspondyloepimetaphysealdysplasia,Missouritype(SEMDMO)
...,cancer,arthritis,andcardiovasculardisease.WeshowthatamissensemutationofMMP13causestheMissouritypeofhumanspondyloepimetaphysealdysplasia(SEMDMO),anautosomaldominantdisordercharacterizedbydefectivegrowthandmodelingofvertebraeandlongbones.Genome-widelinkageanalysismappedSEMDMOtoa17-cMregiononchromosom...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期EosinophilsandCCRRegulateInterleukin-Transgene-InducedPulmonaryRemodeling
【摘要】Interleukin(IL)-13transgeneoverexpressioninthelunginducesfeaturesofchronicinflammatorylungdisorders,includinganeosinophil-richinflammatorycellinfiltration,airwayhyper-reactivity,andremodelingoftheairway(eg,subepithelialfibrosis,gobletcellmetaplasia,andsmoothmusclehypertrophyandhyperplasi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第12期Comparingthepharmacokineticsofdaidzeinandgenisteinwiththeuseof13C-labeledtracersinpremenopausalwomen
...irpharmacokineticsinhumans.Objective:Weinvestigatedthepharmacokineticsofthe13Cisotopicformsofdaidzeinandgenisteininhealthyhumans,specificallyaddressingintraindividualvariability,effectofincreasingintake,andinfluenceofprolongedexposuretoasoyfooddiet.Design:Premenopausalwomen(n=16)wereadministered0.4m...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第2期人成纖維細胞生長因子13基因在酵母細胞中的表達
人成纖維細胞生長因子13基因在酵母細胞中的表達中國免疫學雜誌2000年第8期第16卷分子與細胞免疫學作者:孫蒙 於永利單位:孫蒙(白求恩醫科大學免疫學教研室,長春130021);於永利(白求恩醫科大學免疫學教研室,長春130...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學TranscriptionalRegulationofHumanCYP2A13ExpressionintheRespiratoryTractbyCCAAT/EnhancerBindingProteinandEpigeneticModulation
【關鍵詞】TranscriptionalCYP2A13,whichishighlyactiveinthemetabolicactivationoftobacco-specificnitrosamines,isselectivelyexpressedintherespiratorytract,inwhichitisbelievedtoplayanimportantroleinchemicalcarcinogenesis.Theaimofthisstudywastodeterminethebasisfortissue-specificregulationofCYP2A13gen...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期