DAP12(KARAP)amplifiesinflammationandincreasesmortalityfromendotoxemiaandsepticperitonitis

...hnology,JapanScienceandTechnologyAgency,Honcho4-1-8,Kawaguchi,Saitama332-0012,JapanDAP12(KARAP)isatransmembranesignalingadaptorforafamilyofinnateimmunoreceptorsthathavebeenshowntoactivategranulocytesandmonocytes/macrophages,amplifyingproductionofinflammatorycytokines.Contrastingwiththesedata,recents...

Folicacidfortification:ismaskingofvitaminB-12deficiencywhatweshouldreallyworryabout?

...ndencetoPVerhoef,UnileverFoodandHealthResearchInstitute,OliviervanNoortlaan120,3133ATVlaardingen,Netherlands.Seecorrespondingarticleonpage1187.MandatoryfortificationofflourwithfolicacidhasreducedthenumberofneuraltubedefectsinNorthAmerica(1).ThestudybyWyckoffandGanji(2)inthisissueoftheJournalsuggests...

HyperhomocysteinemiaandvitaminB-12deficiencyinelderlyusingTitleIIIcnutritionservices

...prevalenceofhyperhomocysteinemiaintheolderpopulationwithcoexistingvitaminB-12deficiencyisnotknown.Objective:TheobjectivewastodeterminetheprevalenceofhyperhomocysteinemiaandvitaminB-12deficiencyinelderlywhowereusingTitleIIIcnutritionservices,afterfolatefoodfortificationintheUnitedStates.Design:Demogr...

12/15LipoxygenaseMediatesMonocyteAdhesiontoAorticEndotheliuminApolipoproteinE-DeficientMiceThroughActivationofRhoAandNF-B

【摘要】Objectives-12/15lipoxygenase(12/15LO)hasbeenimplicatedasamediatorofinflammationandatherosclerosis.Inthecurrentstudy,weidentifiedmechanismsthroughwhich12/15LOmediatesmonocyte:endothelialinteractionsinvivoinapolipoproteinE-deficientmice(apoEKO),awell-characterizedmousemodelofatherosclerosi...

人IL-12的克隆、表達及生物活性的鑑定

人IL-12的克隆、表達及生物活性的鑑定中國免疫學雜誌1999年第1期第15卷分子與細胞免疫學作者：曲春楓　孫宗棠單位：中國協和醫科大學腫瘤研究所，北京100021關鍵詞：人IL-12；樹突狀細胞；DNA序列；生物學活性　　中國圖書分...

LowPenetranceBroadResistanceandFavorableOutcomeofInterleukin12Receptorß1Deficiency

...nicalChemistryandImmunology,LeedsGeneralInfirmary,LeedsLS13EX,UnitedKingdom12DepartmentofPediatrics,KingFaycalHospitalandResearchCenter,11211Riyadh,SaudiArabia13PediatricInfectiousDiseasesUnitandDepartmentofImmunology,Valld‘HebronHospital,08035Barcelona,Spain14PrimaryImmunodeficiencyUnit,Departmen...

喘證當分虛實治

...：宣肺散寒。方用麻黃湯加減：麻黃5克，桂枝9克，杏仁12克（打爛），紫蘇12克，橘紅12克，半夏12克（打碎），白前12克，甘草6克。如寒痰滯肺，痰化不暢，加生薑、細辛、紫菀溫肺化痰；如汗喘不已，加桂枝、厚朴調和營衛...

IL-12對狼瘡腎炎PBMC中信號傳遞分子STAT3、STAT4的作用

IL-12對狼瘡腎炎PBMC中信號傳遞分子STAT3、STAT4的作用中國免疫學雜誌2000年第4期第16卷臨牀免疫學作者：李清剛　李幼姬　李志堅　葉任高　許韓師單位：李清剛（中山醫科大學附屬第一醫院腎臟病研究所，廣州510080）；李幼姬（...

南京大學獲2011國家自然科學基金名單(生物類)

...名稱項目負責人依託單位批准金額項目起止年月　　J1103512/J0106南京大學生物學人才培養基地孔令東南京大學4002012-01至2015-12　　81173070/H3104磷酸酶SHP-2調控T細胞免疫應答的功能分子事件與新型藥物靶標孫洋南京大學622012-01至2015-1...

VitaminInterventionforStrokePreventionTrial

...folatefortificationofgrainproducts,inclusionoftherecommendeddailyintakeforB12inthelow-dosearm,treatmentwithparenteralB12inpatientswithlowB12levelsinbothstudyarms,adoseofB12toolowforpatientswithmalabsorption,supplementationwithnonstudyvitamins,andfailureofpatientswithsignificantrenalimpairmenttorespo...