IdentificationandCharacterizationofPDE4A11,aNovel,WidelyExpressedLongIsoformEncodedbytheHumanPDE4AcAMPPhosphodiesteraseGene
...(R.A.S.,R.G.K.)AstraCharnwood,Loughborough,UnitedKingdom(M.S.)AbstractPDE4A11isanovelcAMP-specificphosphodiesterasethatisconservedinhumans,mouse,rat,pig,andbat.Exon-14A11encodesitsunique,81aminoacidN-terminalregion.Reverse-transcriptasepolymerasechainreactionperformedacrossthesplicejunction,plusiden...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期Effectsofcis-9,trans-11conjugatedlinoleicacidsupplementationoninsulinsensitivity,lipidperoxidation,andproinflammatorymarkersinobesemen
...cid(CLA)causesinsulinresistanceinobesemen.However,metaboliceffectsofthec9,t11CLAisomerarestillunknowninobesemen.Becausec9,t11CLAisthepredominantCLAisomerinfoodsandisincludedindietaryweight-lossproducts,itisimportanttoconductrandomizedcontrolledstudiesthatusec9,t11CLApreparations.Objective:Weinvestig...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第2期染色體22q11微缺失與胎兒先天性心臟病關係的研究
【關鍵詞】染色體22q11微缺失;Tbx1基因;TUPLE基因;utd11基因;先天性心臟病 先天性心臟病(congenitalheartdisease,CHD)是一種嚴重威脅患兒健康的常見出生缺陷,在新生活嬰的患病率爲8‰~10‰,是我國出生缺陷監測的主要病種,也...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2012年第10卷第4期高分辨率CT(HRCT)診斷間質性肺炎的價值(附11例報告)
...的CT特徵並評價高分辨率CT(HRCT)的診斷價值。方法本組11例。所有病人均行螺旋CT掃描,並行全肺或局部高分辨率CT(HRCT)掃描。結果良好的掃描技術所獲得的細緻詳盡的影像學資料,結合臨牀,可靠、正確的診斷間質性肺炎。...
合作平臺;在線期刊;中華中西醫雜誌;2005年第6卷第3期;論著TumorsinduceasubsetofinflammatorymonocyteswithimmunosuppressiveactivityonCD8+Tcells
...limittheefficacyofimmunesurveillanceandimmunotherapy.Whiletumor-recruitedCD11b+myeloidcellsareknownmediatorsoftumor-associatedimmunedysfunction,thetruenatureofthesesuppressivecellsandthefinebiochemicalpathwaysgoverningtheirimmunosuppressiveactivityremainelusive.Herewedescribeapopulationofcirculating...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第10期重組人白介素-11治療急性白血病患者化療後血小板減少的臨牀觀察
【摘要】目的觀察重組人白介素-11(rhIL-11)治療急性白血病患者化療後引起的血小板減少的療效和毒副作用。方法治療組35例,化療結束後24h或當血小板≤30×109/L時加用rhIL-1150μg/(kg·d),連續14天或連續兩次檢查血小板恢復至≥10...
醫源資料庫;在線期刊;中華實用醫藥雜誌;2006年第6卷第2期EffectofcombinationtherapywithenalaprilandtheTGF-antagonist1D11inunilateralureteralobstruction
...sbeenindividuallytargeted.Inthisstudy,wesoughttodeterminewhethercombining1D11(monoclonalantibodytoTGF-)andanACEinhibitor,enalapril,wouldbemoreeffectiveinUUOthaneitherindividualtreatment,ashasbeenshownindiabeticandglomerulonephriticmodels.RatsunderwentUUOandweregiveneithercontrolmonoclonalantibody,1D...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第4期ThenuclearreceptorLRH-1criticallyregulatesextra-adrenalglucocorticoidsynthesisintheintestine
...nestimulationandparallelstheinductionofthegenesofthesteroidogenicenzymesCYP11A1andCYP11B1.OverexpressionofLRH-1inmurineintestinalepithelialcellsstronglyinducesthetranscriptionalactivationofthesegenesandpromotesthesynthesisofcorticosterone.Importantly,LRH-1iscriticalforintestinalglucocorticoidsynthes...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第9期腦梗通對局竈腦缺血大鼠外周血中性粒細胞黏附分子CD11b表達的影響
...】目的觀察大鼠局竈腦缺血外周血中性粒細胞黏附分子CD11b的變化及腦梗通對CD11b表達的影響。方法採用血管內拴線阻斷法建立右側大腦中動脈局竈性腦缺血(MCAO)模型,應用流式細胞術檢測腦缺血後不同時相外周血中性粒細胞C...
合作平臺;在線期刊;中華中西醫雜誌;2005年第6卷第4期;論著InvivodepletionoflungCD11c+dendriticcellsduringallergenchallengeabrogatesthecharacteristicfeaturesofasthma
....TostudywhetherDCscontributedtoinflammation,wedepletedDCsfromtheairwaysofCD11c-diphtheriatoxin(DT)receptortransgenicmiceduringtheOVAaerosolchallenge.AirwayadministrationofDTdepletedCD11c+DCsandalveolarmacrophagesandabolishedthecharacteristicfeaturesofasthma,includingeosinophilicinflammation,gobletce...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期