FunctionalCharacterizationofConnexin43MutationsFoundinPatientsWithOculodentodigitalDysplasia
...bstractSpecificmutationsinGJA1,thegeneencodingthegapjunctionproteinconnexin43(Cx43),causeanautosomaldominantdisordercalledoculodentodigitaldysplasia(ODDD).Here,wecharacterizetheeffectsof8ofthesemutationsonCx43function.Immunochemicalstudieshaveshownthatmostofthemutantproteinsformedgapjunctionplaquesa...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第5期Variablegp43SecretionbyParacoccidioidesbrasiliensisClonesObtainedbyTwoDifferentCultureMethods
...omethods(micromanipulationandplatingassay)andtodetermineifthesecretionofthe43-kDaglycoprotein(gp43)isdependentontheclonalculture.Theresultsshowthatthesecretionofgp43isnotdependentonclonalcultures.Clonesthatoriginallyweresecretorsofthismolecule,aftersubculturing,lostthischaracteristic;ontheotherhand,...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第1期EnhancedFunctionalGapJunctionNeoformationbyProteinKinaseAeCDependentandEpac-DependentSignalsDownstreamofcAMPinCardiacMyocytes
...dbytheproteinkinaseA(PKA)eCdependentsignal,andthattheaccumulationofconnexin43(Cx43),themostabundantCxinmyocytes,isenhancedbyanexchangeproteindirectlyactivatedbycAMP(Epac)(Rap1activator)eCdependentsignal.ThegatingfunctionofGJswasanalyzedbymicroinjecteddyetransfermethod.TheaccumulationofCx43wasanalyze...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第9期MatrixProteineCSpecificRegulationofCx43ExpressioninCardiacMyocytesSubjectedtoMechanicalLoad
...axial,pulsatilestretch.Changesinexpressionofthecardiacgapjunctionprotein,Cx43,weremeasuredbyconfocalmicroscopyandimmunoblotting.CellsgrownonfibronectinordenaturedcollagenexhibitedsignificantlygreaterCx43expressionthancellsgrownonnativecollagen.Stretchinduceda2-foldincreaseinCx43expressionincellsgrow...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第3期TDP-inFamilialandSporadicFrontotemporalLobarDegenerationwithUbiquitinInclusions
【摘要】TARDNA-bindingprotein43(TDP-43)isamajorpathologicalproteinofsporadicandfamilialfrontotemporallobardegenerationwithubiquitin-positive,tau-negativeinclusions(FTLD-U)withorwithoutmotorneurondisease(MND).Thus,TDP-43definesanovelclassofneurodegenerativediseasescalledTDP-43proteinopathies.Wepe...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第7期Glucose-evokedalterationsinconnexin43-mediatedcell-to-cellcommunicationinhumancollectingduct:apossibleroleindiabeticnephropathy
...haveutilizedamodelhumancollectingductcellline(HCD)toassesstheroleofconnexin43(Cx43)-mediatedgapjunctionsinthetransferofintracellularCa2+transientswithincoupledcellclusters.HCDcellsexpressCx43mRNAandprotein,aswellasthatforthemechanosensitivetransientreceptorpotentialreceptor(TRPV4).Mechanicalstimulat...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期Cx32、Cx43在慢性淺表性胃炎、癌前病變及胃癌中的表達變化
【摘要】目的觀察Cx32、Cx43在慢性淺表性胃炎(CSG)和癌前病變(PL)和胃癌(GC)中的表達情況。方法採用免疫組織化學SABC法檢測Cx32、Cx43在33例慢性淺表性胃炎、88例癌前病變及70例胃癌患者胃黏膜中表達規律。結果Cx32、Cx43陽性表達...
醫源資料庫;在線期刊;中華現代內科學雜誌;2008年第5卷第3期HeterocellularContactattheMyoendothelialJunctionInfluencesGapJunctionOrganization
...esofmurineECandVSMC.ImmunoctytochemistryandimmunoblotsdemonstratedCx37andCx43inbothcelltypes,whereasCx40wasfoundonlyinEC.Cx37wasexcludedfromtheMEJinbothECandVSMC.ConnexincompositionaswellasfunctionalityofthegapjunctionsattheMEJwasassessedbymeasuringdiffusionaltransferofbiocytinandCy3.Usingconnexin-s...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第7期AntigenicCross-ReactivitybetweenSevereAcuteRespiratorySyndromeAssociatedCoronavirusandHumanCoronaviruses229EandOC43
...respiratorysyndrome(SARS)associatedcoronavirus(SARS-CoV)and2HCoVs(229EandOC43)wasdemonstratedinimmunizedanimalsandhumanserum.In5of11and10of11patientswithSARS,pairedserumsamplesshoweda4-foldincreaseinantibodytitersagainstHCoV-229EandHCoV-OC43,respectively,byIFA.Overall,serumsamplesfromconvalescentpat...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第12期Connexin43-dependentmechanismmodulatesreninsecretionandhypertension
...va,SchoolofMedicine,Geneva,Switzerland.AbstractToinvestigatethefunctionofCx43duringhypertension,westudiedthemouselineCx43KI32(KI32),inwhichthecodingregionofCx32replacesthatofCx43.WithinthekidneysofhomozygousKI32mice,Cx32wasexpressedincorticalandmedullarytubules,aswellasinsomeextra-andintraglomerular...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期