CCL2/MonocyteChemoattractantProtein-1RegulatesInflammatoryResponsesCriticaltoHealingMyocardialInfarcts
...ing,westudiedtheeffectsofMCP-1genedisruptionandantibodyneutralizationinaclosed-chestmodelofreperfusedmurinemyocardialinfarction.MCP-1eC/eCmicehaddecreasedanddelayedmacrophageinfiltrationinthehealinginfarctanddemonstrateddelayedreplacementofinjuredcardiomyocyteswithgranulationtissue.Incontrast,thetim...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期ChronicImmuneReactivityAgainstPersistingMicrobialAntigenintheVasculatureExacerbatesAtheroscleroticLesionFormation
...munereactivityagainstapathogen-derivedpersistingantigeninthevasculature,weusedhypercholesterolemictransgenicmiceconstitutivelyexpressingtheβ-galactosidase(β-gal)transgeneinthecardiovascularsystem(apoE–/–xSM-LacZ).Afterinfectionwithβ-gal–recombinantMCMV-LacZ,apoE&ndas...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第10期Two-photoninvivomicroscopyofsulfonefluoresceinsecretioninnormalandcysticratkidneys
...SFinnormalandcysticratkidneysinvivoand2)totestwhetherSFaccumulationcouldbeusedasamarkerforcystsderivedfromproximaltubules.MaleMunich-Wistarrats,normalHan:SPRDrats,andheterozygousHan:SPRDratswithautosomal-dominantpolycystickidneydiseasewereanesthetizedwithInactinandsolutionscontainingSFwereadminister...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第1期TheInteractionofanImpermeantCationwiththeSheepCardiacRyRChannelAltersRyanoidAssociation
...eantcationthatinteractswithinthevoltagedropacrossRyR.Inaddition,wehaveassessedthemechanismbywhichanimpermeantionalterstheinteractionofryanoidswithRyRbymonitoringinteractionsofarapidlydissociatingryanoidwithsinglechannelsintheabsenceandpresenceofTEA+.Materials.PhosphatidylethanolaminewassuppliedbyAva...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期Parameterestimationoffeedbackgaininastochasticmodelofrenalhemodynamics:differencesbetweenspontaneouslyhypertensiveandSprague-Dawleyrats
...roximaltubularpressure(Pt),andexperimentalstudiesshowthatthephenomenoniscausedbyintrinsicdelaysinTGFsignaltransmission(16).InSprague-Dawley(SprD)andWistarrats,theoscillationsareregular,withonlyonedistinctpeakinthefrequencyspectrumat20-40mHzandanamplitudeof3-4mmHg.Incontrast,inspontaneouslyhypertensi...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期IntrathecalsynthesisofoligoclonalIgMagainstmyelinlipidspredictsanaggressivediseasecourseinMS
...hanti-lipidIgMsufferedasecondrelapseearlier,hadmorerelapses,andshowedincreaseddisabilitycomparedwiththosewithoutanti-lipidIgM.Thepresenceofintrathecalanti–myelinlipidIgMantibodiesisthereforeaveryaccuratepredictorofaggressiveevolutioninMS.IntroductionMSisademyelinatingdiseaseoftheCNSofunknownetiolo...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期End-stagerenaldiseasecausesanimbalancebetweenendothelialandsmoothmuscleprogenitorcells
...摘要】Patientswithend-stagerenaldisease(ESRD)onhemodialysishaveanincreasedriskofcardiovasculardisease(CVD).Circulatingendothelialprogenitorcells(EPC)contributetovascularregenerationandrepair,therebyprotectingagainstCVD.However,circulatingsmoothmuscleprogenitorcells(SPC)maycontributetoadversevascu...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第4期Aconsensussequenceintheendothelin-BreceptorsecondintracellularloopisrequiredforNHE3activationbyendothelin-1
...nalmechanismisrequiredforNHE3stimulationbytheETBreceptor.ThepresentstudiesusedETAandETBreceptorchimerasandsite-directedmutagenesistoidentifytheETreceptordomainsthatmediateET-1regulationofNHE3activity.WefoundthatbindingofET-1totheETAreceptorinhibitsNHE3activity,aneffectforwhichtheCOOH-terminaltailisn...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期ActivationoftheEndothelialStore-OperatedISOCCa2+ChannelRequiresInteractionofProtein4.1WithTRPC4
...ngfortheentryofextracellularCa2+intothecytosolaretheprincipalsourceofincreased[Ca2+]i.Innonexcitablecells,store-operatedcalcium(SOC),andtoalesserextent,receptor-operatedcalcium(ROC),entrychannelsrepresentthemainsourceofcalciumentry.1,2AlthoughitisgenerallyrecognizedthatSOCentryoccursthroughCa2+-sele...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第11期EffectofOxidationonthePlatelet-ActivatingPropertiesofLow-DensityLipoprotein
...dicacidIntroductionPatientswithfamilialhypercholesterolemia(FH)showanincreasedincidenceofprematurecoronaryarterydisease.Thesepatientslackorhaveadefectivereceptorforlow-densitylipoprotein(LDL),theapolipoprotein(apo)B/E-receptor,1whichresultsinanimpaireduptakeofLDLfromthecirculation.LDLaccumulatesandb...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第4期