DiabeticMicroangiopathyinIschemicLimbIsaDiseaseofDisturbanceofthePlatelet-DerivedGrowthFactor-BB/ProteinKinaseCAxisbutNotofImpairedExpre
...daspreviouslydescribed.5eC8Humanfull-lengthcDNAofPDGF-B(GenBankaccessionno.BC029822)wasamplifiedbyPCRusingspecificprimers(forward:5‘-AAGGTACCATGAATCGCTG-CTGGGCGCTC-3‘;reverse:5‘-TTCTCGAGCTAGGCTCCAAGGGTCTCCTTC-3‘)andsubclonedintotheTAcloningvector(Invitrogen,SanDiego,Calif).Theentiresequencew...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第1期Rescueofp53BlockagebytheA2AAdenosineReceptorviaaNovelInteractingProtein,Translin-AssociatedProteinX
...,1993).TheA2A-R-truncatedmutantsweregeneratedfrompcDNA3-A2A-RbyPCRandweresubclonedintoapcDNA3.1/V5-Hisvector.PrimersforcreatingA2A-R253-410wereasfollows:5‘-ACCATGTTCTGCTCCACGTGCCGG-3‘and5‘-GGAAGGGGCAAACTCTGAAGA-3‘.TheantisenseconstructofTRAX(TRAXAS,encodingtheRNAcontainingnucleotides451to870...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期CorrelatesofOxidativeStressandFree-RadicalActivityinSerumfromAsymptomaticShipyardWelders
...eatshockprotein70(Hsp70;IgG/A/M)ELISAkit(StressgenBiotechnologies,Victoria,BC,Canada)wasusedtodeterminetheamountofIgG,IgA,andIgMantibodiestohumanHsp70inserumsamplesfromweldersandcontrolsubjects,accordingtothemanufacturer‘sprotocol.Briefly,serumsamplesweredilutedto1:500,usingsamplediluent,and100-μ...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第12期InactivationofthePRDM1/BLIMP1geneindiffuselargeBcelllymphoma
...n1(BLIMP1)isatranscriptionalrepressorexpressedinasubsetofgerminalcenter(GC)Bcellsandinallplasmacells,andrequiredforterminalBcelldifferentiation.TheBLIMP1locusliesonchromosome6q21-q22.1,aregionfrequentlydeletedinBcelllymphomas,suggestingthatitmayharboratumorsuppressorgene.WereportherethattheBLIMP1gen...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第2期CharacterizationofanNBS1C-TerminalPeptideThatCanInhibitAtaxiaTelangiectasiaMutated(ATM)-MediatedDNADamageResponsesandEnhanceRadiosensitivity
...werecapturedat40xmagnificationusingaRetigaEXidigitalcamera(QImaging,Surrey,BC,Canada)andanalyzedwithImage-ProPlussoftware(ver.4.1;MediaCybernetics,Inc.,Bethesda,MD).MTTAssay.Forcytotoxicitystudies,exponentiallygrowingculturesofHeLaorDU-145cellswereharvested,platedin96-wellplates(5000cells/well)incom...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期Proteinuriaasadeterminantofrenalexpressionofhemeoxygenase-1:studiesinmodelsofglomerularandtubularproteinuriaintherat
...ney.Insubsequentstudies,maleate-treatedandvehicle-treatedratswereinjectedsubcutaneouslywithaninhibitorofHOactivity,tinprotoporphyrin(SnPP;20μmol/kg,PorphyrinProducts,Logan,UT)orsalinevehicle,administered3hbefore,and5and24hafter,theadministrationofmaleate(25).Inthesestudies,urinaryproteinexcretionwa...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第1期DiscriminationwithinPhenotypicallyCloselyRelatedDefinitiveTypesofSalmonellaentericaSerovarTyphimuriumbytheMultipleAmplificationofPhageLocus
...2couldbeseparatedfromtheothersevenisolatesinthisclusterbasedupontheimmCST64Bc15‘sequence.Incluster2,isolate02-108-001couldbeseparatedfromtheotherthreeisolatesbasedupontheimmCST64Bregion.Incluster3,nofurtherseparationcouldbeachieved.Cluster4comprisedtwoisolates,whichcouldbeseparatedbasedupondiffere...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期ThreoninerequirementsofhealthyIndianmen,measuredbya24-hindicatoraminoacidoxidationandbalancetechnique
...nonRYoung1FromtheDepartmentofPhysiologyandtheDivisionofNutrition(AVK,TR,JV,BC,andDN)andtheDepartmentofBiochemistry(JG),StJohnsMedicalCollege,Bangalore,India,andtheLaboratoryofHumanNutrition,MassachusettsInstituteofTechnology,Cambridge,MA(MMRandVRY).2SupportedbytheNestléFoundation,Switze...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第4期InductionofvascularleakagethroughreleaseofbradykininandanovelkininbycysteineproteinasesfromStaphylococcusaureus
...y.StaphopainswerepurifiedfromtheculturemediasupernatantsofS.aureusstrainV8-BC10or8325-4asdescribedpreviously(31).PurityofstaphopainswasassessedbySDS-PAGE,massspectroscopy,andNH2-terminalaminoacidsequenceanalysis.Theenzymeswereshowntobehomogenousproteinswithamolecularmassof21kD(Fig.6,panelE);thismatc...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第10期Roleofinterleukin-1(IL-1)inthepathogenesisofsystemiconsetjuvenileidiopathicarthritisandclinicalresponsetoIL-1blockade
...liximab)therapyfor12–25mowithoutimprovement.rIL-1Rawasinitiatedasadailysubcutaneousinjectionat2mg/kg,upto100mg.Patientswerefollowedevery2mowithacompletephysicalexaminationandlaboratorytestsforanaverageof6.6mo(range2–12mo)aftertherapyinitiation.Allninepatientsrespondedtotherapy.Allpatientswhoexpe...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期