Pathomechanismsinrheumatoidarthritis—timeforastringtheory?
KathleenB.andMasonI.LowanceCenterforHumanImmunology,DepartmentofMedicine,EmorySchoolofMedicine,Atlanta,Georgia,USA.AbstractRAisaquintessentialautoimmunediseasewithagrowingnumberofcells,mediators,andpathwaysimplicatedinthistissue-injuriousinflammation.NowKuhnandcolleagueshaveprovidedconvincingevidenc...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第4期C5aandFcreceptors:amutualadmirationsociety
...ofactivating(proinflammatory-type)FcRs.Moreover,engagementofFcRsbytheIgG-bearingimmunecomplexinstructsthecelltosynthesizemoreC5,fromwhichC5aisderived.Thus,thisworkestablishesafeedbackloopwherebyFcRexpressionandfunctionareenhanced,averydesirableeventinconcertwithaninfectionbutpotentiallydeleteriousin...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期氣相色譜檢測垃圾填埋氣
...純,丙酮、丁酮和苯乙酮均爲分析純。2,4-二硝基苯肼,AR;二硫化碳,AR,現用現蒸;雙蒸水用前現蒸。2,4-二硝基苯肼吸收液:用1mol·l-1硫酸溶解適量2,4-二硝基苯肼固體,製成飽和溶液,用1/10(V/V)二硫化碳提取兩次。吸...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例PPAR-ligandamelioratesacuterenalfailurebyreducingcisplatin-inducedincreasedexpressionofrenalendonucleaseG
【摘要】Cisplatininjurytothekidneyischaracterized,inpart,byinhibitionofsubstrateoxidation,inflammation,andtubularcelldeathintheformofapoptosisandnecrosis.Recently,wedemonstratedthatcisplatin-inducedinhibitionofsubstrateoxidationcanbereversedbytheadministrationofperoxisomeproliferator-activatedre...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期Metabolicbiomarkersofincreasedoxidativestressandimpairedmethylationcapacityinchildrenwithautism
...k,StefanieJernigan,LauretteJanak,DavidWGaylorandJamesANeubrander1FromtheDepartmentofPediatrics,UniversityofArkansasforMedicalSciences,andtheArkansasChildren‘sHospitalResearchInstitute,LittleRock,AR(SJJ,SM,andSJ);NiagaraFalls,NY(PC);Colden,NY(LJ);GaylorandAssociates,LLC,EurekaSprings,AR(DWG);andEdi...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第6期GProtein–CoupledReceptorOligomerizationImplicationsforGProteinActivationandCellSignaling
...fGPCR...MinimalModelforGPCR...FunctionalConsequencesofGPCR...ImportanceforCardiovascular...ReferencesThecardiovascularsystemisrichlyendowedwithGprotein–coupledreceptors(GPCRs),membersofthelargestfamilyofplasmamembrane-localizedreceptors.Duringthelast10years,ithasbecomeincreasinglyclearthatmany,ifn...
醫源資料庫;在線期刊;循環研究雜誌;2004年第94卷第1期ACriticalRoleforPeroxisomalProliferator-ActivatedReceptor-NuclearReceptorsintheDevelopmentofCardiomyocyteDegenerationandNecrosis
【摘要】Peroxisomalproliferator-activatedreceptor(PPAR)-isaligand-activatedtranscriptionalfactorthatregulatesgenesinvolvedinlipidmetabolismandenergyhomeostasis.PPAR-activators,includingfibrates,havebeenusedtotreatdyslipidemiaforseveraldecades.Incontrasttotheirknowneffectsonlipids,thepharmacologi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第9期Adenosine2AreceptorvasodilationofratpreglomerularmicrovesselsismediatedbyEETsthatactivatethecAMP/PKApathway
【摘要】Dilationofratpreglomerularmicrovessels(PGMV)byactivationofadenosineA2Areceptors(A2AR)iscoupledtoepoxyeicosatrienoicacid(EET)release.Wehaveinvestigatedthecommonalityofthissignaltransductionpathway,i.e.,sequentialinhibitionofGs,adenylylcyclase,PKA,andCa2+-activatedK+(KCa)channelactivity,to...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期油浸食品中防腐劑反相高效液相色譜法測定
...氫溶液;002mol/L乙酸銨溶液;石油醚乙醚混合液:石油醚(AR)+乙醚(AR)=3+1;甲醇:色譜純。 13儀器條件色譜柱:KromasilC18(250×46mm,ID5μm);流動相:甲醇+002mol/L乙酸銨溶液=5+95;流速:10ml/mim;進樣量:5μl;柱溫:室溫;檢測波長...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文毛細管電泳法快速測定複方地芬諾酯片中的地芬諾酯和阿托品
...功能性腹瀉和慢性腸炎等。阿托品(Atropine)爲典型的M膽鹼受體阻滯劑。地芬諾酯長期服用易產生依賴性,配以阿托品,可協同加強對腸管蠕動的抑制作用,並抑制依賴性傾向,故臨牀常用兩者的複方製劑。地芬諾酯的測定多采用...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例